A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases (original) (raw)
Fukagawa, T. et al. Dicer is essential for formation of the heterochromatin structure in vertebrate cells. Nat. Cell Biol.6, 784–791 (2004). ArticleCAS Google Scholar
Kanellopoulou, C. et al. Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes Dev.19, 489–501 (2005). ArticleCAS Google Scholar
Volpe, T.A. et al. Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi. Science297, 1833–1837 (2002). ArticleCAS Google Scholar
Hall, I.M. et al. Establishment and maintenance of a heterochromatin domain. Science297, 2232–2237 (2002). ArticleCAS Google Scholar
Pal-Bhadra, M. et al. Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery. Science303, 669–672 (2004). ArticleCAS Google Scholar
Verdel, A. et al. RNAi-mediated targeting of heterochromatin by the RITS complex. Science303, 672–676 (2004). ArticleCAS Google Scholar
Cobb, B.S. et al. T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer. J. Exp. Med.201, 1367–1373 (2005). ArticleCAS Google Scholar
Murchison, E.P. et al. Characterization of Dicer-deficient murine embryonic stem cells. Proc. Natl. Acad. Sci. USA102, 12135–12140 (2005). ArticleCAS Google Scholar
Wang, F. et al. The assembly and maintenance of heterochromatin initiated by transgene repeats are independent of the RNA interference pathway in mammalian cells. Mol. Cell. Biol.26, 4028–4040 (2006). ArticleCAS Google Scholar
Hall, I.M., Noma, K. & Grewal, S.I. RNA interference machinery regulates chromosome dynamics during mitosis and meiosis in fission yeast. Proc. Natl. Acad. Sci. USA100, 193–198 (2003). ArticleCAS Google Scholar
Sugiyama, T., Cam, H., Verdel, A., Moazed, D. & Grewal, S.I. RNA-dependent RNA polymerase is an essential component of a self-enforcing loop coupling heterochromatin assembly to siRNA production. Proc. Natl. Acad. Sci. USA102, 152–157 (2005). ArticleCAS Google Scholar
Li, E., Beard, C. & Jaenisch, R. Role for DNA methylation in genomic imprinting. Nature366, 362–365 (1993). ArticleCAS Google Scholar
Lehnertz, B. et al. Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin. Curr. Biol.13, 1192–1200 (2003). ArticleCAS Google Scholar
Gonzalo, S. et al. DNA methyltransferases control telomere length and telomere recombination in mammalian cells. Nat. Cell Biol.8, 416–424 (2006). ArticleCAS Google Scholar
Esteller, M. Relevance of DNA methylation in the management of cancer. Lancet Oncol.4, 351–358 (2003). ArticleCAS Google Scholar
Dodge, J.E. et al. Inactivation of Dnmt3b in mouse embryonic fibroblasts results in DNA hypomethylation, chromosomal instability, and spontaneous immortalization. J. Biol. Chem.280, 17986–17991 (2005). ArticleCAS Google Scholar
Okano, M., Xie, S. & Li, E. Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases. Nat. Genet.19, 219–220 (1998). ArticleCAS Google Scholar
Okano, M., Bell, D.W., Haber, D.A. & Li, E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell99, 247–257 (1999). ArticleCAS Google Scholar
Li, E., Bestor, T.H. & Jaenisch, R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell69, 915–926 (1992). ArticleCAS Google Scholar
Chen, T., Ueda, Y., Dodge, J.E., Wang, Z. & Li, E. Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b. Mol. Cell. Biol.23, 5594–5605 (2003). ArticleCAS Google Scholar
Chen, T., Tsujimoto, N. & Li, E. The PWWP domain of Dnmt3a and Dnmt3b is required for directing DNA methylation to the major satellite repeats at pericentric heterochromatin. Mol. Cell. Biol.24, 9048–9058 (2004). ArticleCAS Google Scholar
Garcia-Cao, M., O'Sullivan, R., Peters, A.H., Jenuwein, T. & Blasco, M.A. Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases. Nat. Genet.36, 94–99 (2004). ArticleCAS Google Scholar
García-Cao, M., Gonzalo, S., Dean, D. & Blasco, M.A. Role of the Rb family members in controlling telomere length. Nat. Genet.32, 415–419 (2002). Article Google Scholar
Gonzalo, S. et al. Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin. Nat. Cell Biol.7, 420–428 (2005). ArticleCAS Google Scholar
Benetti, R., Garcia-Cao, M. & Blasco, M.A. Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeres. Nat. Genet.39, 243–250 (2007). ArticleCAS Google Scholar
Benetti, R. et al. Suv4–20h deficiency results in telomere elongation and de-repression of telomere recombination. J. Cell Biol.178, 925–936 (2007). ArticleCAS Google Scholar
Blackburn, E.H. Switching and signaling at the telomere. Cell106, 661–673 (2001). ArticleCAS Google Scholar
de Lange, T. Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev.19, 2100–2110 (2005). ArticleCAS Google Scholar
Muntoni, A. & Reddel, R.R. The first molecular details of ALT in human tumor cells. Hum. Mol. Genet.14, R191–R196 (2005). ArticleCAS Google Scholar
Dunham, M.A., Neumann, A.A., Fasching, C.L. & Reddel, R.R. Telomere maintenance by recombination in human cells. Nat. Genet.26, 447–450 (2000). ArticleCAS Google Scholar
Bailey, S.M., Brenneman, M.A. & Goodwin, E.H. Frequent recombination in telomeric DNA may extend the proliferative life of telomerase-negative cells. Nucleic Acids Res.32, 3743–3751 (2004). ArticleCAS Google Scholar
Azzalin, C.M., Reichenbach, P., Khoriauli, L., Giulotto, E. & Lingner, J. Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends. Science318, 798–801 (2007). ArticleCAS Google Scholar
Schoeftner, S. & Blasco, M.A. Developmentally regulated transcription of mammalian telomeres by DNA dependent RNA polymerase II. Nat Cell Biol.10, 228–236 (2007). Article Google Scholar
Houbaviy, H.B., Dennis, L., Jaenisch, R. & Sharp, P.A. Characterization of a highly variable eutherian microRNA gene. RNA11, 1245–1257 (2005). ArticleCAS Google Scholar
Houbaviy, H.B., Murray, M.F. & Sharp, P.A. Embryonic stem cell-specific MicroRNAs. Dev. Cell5, 351–358 (2003). ArticleCAS Google Scholar
Andl, T. et al. The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles. Curr. Biol.16, 1041–1049 (2006). ArticleCAS Google Scholar
Reichenbach, P. et al. A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed. Curr. Biol.13, 568–574 (2003). ArticleCAS Google Scholar
Zhou, X.Z. & Lu, K.P. The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. Cell107, 347–359 (2001). ArticleCAS Google Scholar
Landgraf, P. et al. A mammalian microRNA expression atlas based on small RNA library sequencing. Cell129, 1401–1414 (2007). ArticleCAS Google Scholar
Berezikov, E. et al. Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis. Genome Res.16, 1289–1298 (2006). ArticleCAS Google Scholar
Chano, T. et al. Identification of RB1CC1, a novel human gene that can induce RB1 in various human cells. Oncogene21, 1295–1298 (2002). ArticleCAS Google Scholar
Skapek, S.X. et al. Cloning and characterization of a novel Kruppel-associated box family transcriptional repressor that interacts with the retinoblastoma gene product, RB. J. Biol. Chem.275, 7212–7223 (2000). ArticleCAS Google Scholar
Lai, A. et al. RBP1 recruits the mSIN3-histone deacetylase complex to the pocket of retinoblastoma tumor suppressor family proteins found in limited discrete regions of the nucleus at growth arrest. Mol. Cell. Biol.21, 2918–2932 (2001). ArticleCAS Google Scholar
McCabe, M.T., Low, J.A., Imperiale, M.J. & Day, M.L. Human polyomavirus BKV transcriptionally activates DNA methyltransferase 1 through the pRb/E2F pathway. Oncogene25, 2727–2735 (2006). ArticleCAS Google Scholar
McCabe, M.T. et al. Inhibition of DNA methyltransferase activity prevents tumorigenesis in a mouse model of prostate cancer. Cancer Res.66, 385–392 (2006). ArticleCAS Google Scholar
McCabe, M.T., Davis, J.N. & Day, M.L. Regulation of DNA methyltransferase 1 by the pRb/E2F1 pathway. Cancer Res.65, 3624–3632 (2005). ArticleCAS Google Scholar
Kimura, H., Nakamura, T., Ogawa, T., Tanaka, S. & Shiota, K. Transcription of mouse DNA methyltransferase 1 (Dnmt1) is regulated by both E2F-Rb-HDAC-dependent and -independent pathways. Nucleic Acids Res.31, 3101–3113 (2003). ArticleCAS Google Scholar
Pradhan, S. & Kim, G.D. The retinoblastoma gene product interacts with maintenance human DNA (cytosine-5) methyltransferase and modulates its activity. EMBO J.21, 779–788 (2002). ArticleCAS Google Scholar
Simin, K. et al. pRb inactivation in mammary cells reveals common mechanisms for tumor initiation and progression in divergent epithelia. PLoS Biol.2, e22 (2004). Article Google Scholar
Brehm, A. et al. Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature391, 597–601 (1998). ArticleCAS Google Scholar
Shiota, K. & Yanagimachi, R. Epigenetics by DNA methylation for development of normal and cloned animals. Differentiation69, 162–166 (2002). ArticleCAS Google Scholar
Ohgane, J., Hattori, N., Oda, M., Tanaka, S. & Shiota, K. Differentiation of trophoblast lineage is associated with DNA methylation and demethylation. Biochem. Biophys. Res. Commun.290, 701–706 (2002). ArticleCAS Google Scholar
Liu, L. et al. Telomere lengthening early in development. Nat. Cell Biol.9, 1436–1441 (2007). ArticleCAS Google Scholar
Samper, E., Goytisolo, F.A., Slijepcevic, P., van Buul, P.P. & Blasco, M.A. Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang. EMBO Rep.1, 244–252 (2000). ArticleCAS Google Scholar
Zijlmans, J.M. et al. Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats. Proc. Natl. Acad. Sci. USA94, 7423–7428 (1997). ArticleCAS Google Scholar
Muñoz, P., Blanco, R., Flores, J.M. & Blasco, M.A. XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer. Nat. Genet.37, 1063–1071 (2005). Article Google Scholar
Bailey, S.M. et al. Strand-specific postreplicative processing of mammalian telomeres. Science293, 2462–2465 (2001). ArticleCAS Google Scholar
Benjamini, Y. & Hochberg, Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. Ser. B.57, 289–300 (1995). Google Scholar
Goff, L.A. et al. Rational probe optimization and enhanced detection strategy. RNA Biol.2, 93–100 (2005). ArticleCAS Google Scholar