Role of mammalian Mre11 in classical and alternative nonhomologous end joining (original) (raw)

• Williams, R.S., Williams, J.S. & Tainer, J.A. Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template. Biochem. Cell Biol. 85, 509–520 (2007).
  Article CAS Google Scholar
• Berkovich, E., Monnat, R.J. Jr. & Kastan, M.B. Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair. Nat. Cell Biol. 9, 683–690 (2007).
  Article CAS Google Scholar
• Lee, J.H. & Paull, T.T. ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science 308, 551–554 (2005).
  Article CAS Google Scholar
• Stucki, M. & Jackson, S.P. γH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes. DNA Repair (Amst.) 5, 534–543 (2006).
  Article CAS Google Scholar
• Bekker-Jensen, S. et al. Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. J. Cell Biol. 173, 195–206 (2006).
  Article CAS Google Scholar
• Luo, G. et al. Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation. Proc. Natl. Acad. Sci. USA 96, 7376–7381 (1999).
  Article CAS Google Scholar
• Xiao, Y. & Weaver, D.T. Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells. Nucleic Acids Res. 25, 2985–2991 (1997).
  Article CAS Google Scholar
• Zhu, J., Petersen, S., Tessarollo, L. & Nussenzweig, A. Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice. Curr. Biol. 11, 105–109 (2001).
  Article CAS Google Scholar
• Stewart, G.S. et al. The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder. Cell 99, 577–587 (1999).
  Article CAS Google Scholar
• Carney, J.P. et al. The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response. Cell 93, 477–486 (1998).
  Article CAS Google Scholar
• Dudley, D.D., Chaudhuri, J., Bassing, C.H. & Alt, F.W. Mechanism and control of V(D)J recombination versus class switch recombination: similarities and differences. Adv. Immunol. 86, 43–112 (2005).
  Article CAS Google Scholar
• Lieber, M.R. The mechanism of human nonhomologous DNA end joining. J. Biol. Chem. 283, 1–5 (2008).
  Article CAS Google Scholar
• Corneo, B. et al. Rag mutations reveal robust alternative end joining. Nature 449, 483–486 (2007).
  Article CAS Google Scholar
• Guirouilh-Barbat, J., Rass, E., Plo, I., Bertrand, P. & Lopez, B.S. Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends. Proc. Natl. Acad. Sci. USA 104, 20902–20907 (2007).
  Article CAS Google Scholar
• Soulas-Sprauel, P. et al. Role for DNA repair factor XRCC4 in immunoglobulin class switch recombination. J. Exp. Med. 204, 1717–1727 (2007).
  Article CAS Google Scholar
• Yan, C.T. et al. IgH class switching and translocations use a robust non-classical end-joining pathway. Nature 449, 478–482 (2007).
  Article CAS Google Scholar
• Haber, J.E. Alternative endings. Proc. Natl. Acad. Sci. USA 105, 405–406 (2008).
  Article CAS Google Scholar
• Limbo, O. et al. Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination. Mol. Cell 28, 134–146 (2007).
  Article CAS Google Scholar
• Mimitou, E.P. & Symington, L.S. Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing. Nature 455, 770–774 (2008).
  Article CAS Google Scholar
• Zhu, Z., Chung, W.H., Shim, E.Y., Lee, S.E. & Ira, G. Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends. Cell 134, 981–994 (2008).
  Article CAS Google Scholar
• Sartori, A.A. et al. Human CtIP promotes DNA end resection. Nature 450, 509–514 (2007).
  Article CAS Google Scholar
• Bhaskara, V. et al. Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes. Mol. Cell 25, 647–661 (2007).
  Article CAS Google Scholar
• Stracker, T.H., Theunissen, J.W., Morales, M. & Petrini, J.H. The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together. DNA Repair (Amst.) 3, 845–854 (2004).
  Article CAS Google Scholar
• Williams, R.S. et al. Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair. Cell 135, 97–109 (2008).
  Article CAS Google Scholar
• Moore, J.K. & Haber, J.E. Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiae. Mol. Cell. Biol. 16, 2164–2173 (1996).
  Article CAS Google Scholar
• Chen, L., Trujillo, K., Ramos, W., Sung, P. & Tomkinson, A.E. Promotion of Dnl4-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 complexes. Mol. Cell 8, 1105–1115 (2001).
  Article CAS Google Scholar
• Ma, J.L., Kim, E.M., Haber, J.E. & Lee, S.E. Yeast Mre11 and Rad1 proteins define a Ku-independent mechanism to repair double-strand breaks lacking overlapping end sequences. Mol. Cell. Biol. 23, 8820–8828 (2003).
  Article CAS Google Scholar
• Huang, J. & Dynan, W.S. Reconstitution of the mammalian DNA double-strand break end-joining reaction reveals a requirement for an Mre11/Rad50/NBS1-containing fraction. Nucleic Acids Res. 30, 667–674 (2002).
  Article CAS Google Scholar
• Zhong, Q., Boyer, T.G., Chen, P.L. & Lee, W.H. Deficient nonhomologous end-joining activity in cell-free extracts from _Brca1_-null fibroblasts. Cancer Res. 62, 3966–3970 (2002).
  CAS PubMed Google Scholar
• Di Virgilio, M. & Gautier, J. Repair of double-strand breaks by nonhomologous end joining in the absence of Mre11. J. Cell Biol. 171, 765–771 (2005).
  Article CAS Google Scholar
• Deriano, L., Stracker, T.H., Baker, A., Petrini, J.H. & Roth, D.B. Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates. Mol. Cell 34, 13–25 (2009).
  Article CAS Google Scholar
• Helmink, B.A. et al. MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks. J. Exp. Med. 206, 669–679 (2009).
  Article CAS Google Scholar
• Yan, C.T. et al. XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice. Proc. Natl. Acad. Sci. USA 103, 7378–7383 (2006).
  Article CAS Google Scholar
• de Jager, M. et al. Human Rad50/Mre11 is a flexible complex that can tether DNA ends. Mol. Cell 8, 1129–1135 (2001).
  Article CAS Google Scholar
• Hopfner, K.P. et al. The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair. Nature 418, 562–566 (2002).
  Article CAS Google Scholar
• Reina-San-Martin, B. et al. H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation. J. Exp. Med. 197, 1767–1778 (2003).
  Article CAS Google Scholar
• Franco, S. et al. H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol. Cell 21, 201–214 (2006).
  Article CAS Google Scholar
• Dimitrova, N. & de Lange, T. MDC1 accelerates nonhomologous end-joining of dysfunctional telomeres. Genes Dev. 20, 3238–3243 (2006).
  Article CAS Google Scholar
• Bassing, C.H. et al. Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX. Proc. Natl. Acad. Sci. USA 99, 8173–8178 (2002).
  Article CAS Google Scholar
• Celeste, A. et al. Genomic instability in mice lacking histone H2AX. Science 296, 922–927 (2002).
  Article CAS Google Scholar
• Lou, Z. et al. MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol. Cell 21, 187–200 (2006).
  Article CAS Google Scholar
• Xie, A. et al. Control of sister chromatid recombination by histone H2AX. Mol. Cell 16, 1017–1025 (2004).
  Article CAS Google Scholar
• Xie, A. et al. Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair. Mol. Cell 28, 1045–1057 (2007).
  Article CAS Google Scholar
• Celeste, A. et al. Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks. Nat. Cell Biol. 5, 675–679 (2003).
  Article CAS Google Scholar
• Boulton, S.J. & Jackson, S.P. Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing. EMBO J. 17, 1819–1828 (1998).
  Article CAS Google Scholar
• Zhang, X. & Paull, T.T. The Mre11/Rad50/Xrs2 complex and non-homologous end-joining of incompatible ends in S. cerevisiae. DNA Repair (Amst.) 4, 1281–1294 (2005).
  Article CAS Google Scholar
• Lee, S.E., Bressan, D.A., Petrini, J.H. & Haber, J.E. Complementation between N-terminal Saccharomyces cerevisiae mre11 alleles in DNA repair and telomere length maintenance. DNA Repair (Amst.) 1, 27–40 (2002).
  Article CAS Google Scholar
• Moreau, S., Morgan, E.A. & Symington, L.S. Overlapping functions of the Saccharomyces cerevisiae Mre11, Exo1 and Rad27 nucleases in DNA metabolism. Genetics 159, 1423–1433 (2001).
  CAS PubMed PubMed Central Google Scholar
• Zhang, Y. et al. Role of Dnl4-Lif1 in nonhomologous end-joining repair complex assembly and suppression of homologous recombination. Nat. Struct. Mol. Biol. 14, 639–646 (2007).
  Article CAS Google Scholar
• Riha, K., Heacock, M.L. & Shippen, D.E. The role of the nonhomologous end-joining DNA double-strand break repair pathway in telomere biology. Annu. Rev. Genet. 40, 237–277 (2006).
  Article CAS Google Scholar
• Gao, Y. et al. A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination. Immunity 9, 367–376 (1998).
  Article CAS Google Scholar
• Li, G. et al. Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination. Mol. Cell 31, 631–640 (2008).
  Article CAS Google Scholar
• Dinkelmann, M. et al. Multiple functions of MRN in end-joining pathways during isotype class switching. Nat. Struct. Mol. Biol. advance online publication: doi:10.1038/nsmb.1639 (26 July 2009).
• Rass, E. et al. Role of MRE11 in chromosomal non-homologous end-joining in mammalian cells. Nat. Struct. Mol. Biol. advance online publication, doi:10.1038/nsmb.1641 (26 July 2009).