DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS (original) (raw)
Rubin, L.L. & de Sauvage, F.J. Targeting the Hedgehog pathway in cancer. Nat. Rev. Drug Discov.5, 1026–1033 (2006). ArticleCASPubMed Google Scholar
Watkins, D.N. et al. Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature422, 313–317 (2003). ArticleCASPubMed Google Scholar
Berman, D.M. et al. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature425, 846–851 (2003). ArticleCASPubMed Google Scholar
Stecca, B. et al. Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways. Proc. Natl. Acad. Sci. USA104, 5895–5900 (2007). ArticleCASPubMedPubMed Central Google Scholar
Malumbres, M. & Barbacid, M. RAS oncogenes: the first 30 years. Nat. Rev. Cancer3, 459–465 (2003). ArticleCASPubMed Google Scholar
Hezel, A.F., Kimmelman, A.C., Stanger, B.Z., Bardeesy, N. & Depinho, R.A. Genetics and biology of pancreatic ductal adenocarcinoma. Genes Dev.20, 1218–1249 (2006). ArticleCASPubMed Google Scholar
Hingorani, S.R. et al. Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell7, 469–483 (2005). ArticleCASPubMed Google Scholar
Feldmann, G. et al. Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers. Cancer Res.67, 2187–2196 (2007). ArticleCASPubMedPubMed Central Google Scholar
Feldmann, G. et al. Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer. Gut57, 1420–1430 (2008). ArticleCASPubMed Google Scholar
Jones, S. et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science321, 1801–1806 (2008). ArticleCASPubMedPubMed Central Google Scholar
Yauch, R.L. et al. A paracrine requirement for hedgehog signalling in cancer. Nature455, 406–410 (2008). ArticleCASPubMed Google Scholar
Habbe, N. et al. Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice. Proc. Natl. Acad. Sci. USA105, 18913–18918 (2008). ArticleCASPubMedPubMed Central Google Scholar
De La O, J.P. et al. Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia. Proc. Natl. Acad. Sci. USA105, 18907–18912 (2008). ArticleCASPubMedPubMed Central Google Scholar
Guerra, C. et al. Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell11, 291–302 (2007). ArticleCASPubMed Google Scholar
Morton, J.P. et al. Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis. Proc. Natl. Acad. Sci. USA104, 5103–5108 (2007). ArticleCASPubMedPubMed Central Google Scholar
Fendrich, V. et al. Hedgehog signaling is required for effective regeneration of exocrine pancreas. Gastroenterology135, 621–631 (2008). ArticleCASPubMed Google Scholar
Schubbert, S., Shannon, K. & Bollag, G. Hyperactive Ras in developmental disorders and cancer. Nat. Rev. Cancer7, 295–308 (2007). ArticleCASPubMed Google Scholar
Quint, K. et al. The expression pattern of PDX-1, SHH, Patched and Gli-1 is associated with pathological and clinical features in human pancreatic cancer. Pancreatology9, 116–126 (2009). ArticleCASPubMed Google Scholar
Taipale, J. et al. Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature406, 1005–1009 (2000). ArticleCASPubMed Google Scholar
Chen, J.K., Taipale, J., Young, K.E., Maiti, T. & Beachy, P.A. Small molecule modulation of Smoothened activity. Proc. Natl. Acad. Sci. USA99, 14071–14076 (2002). ArticleCASPubMedPubMed Central Google Scholar
Guerra, C. et al. Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context. Cancer Cell4, 111–120 (2003). ArticleCASPubMed Google Scholar
Wakabayashi, Y., Mao, J.H., Brown, K., Girardi, M. & Balmain, A. Promotion of Hras-induced squamous carcinomas by a polymorphic variant of the Patched gene in FVB mice. Nature445, 761–765 (2007). ArticleCASPubMed Google Scholar
Svard, J. et al. Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway. Dev. Cell10, 187–197 (2006). ArticlePubMed Google Scholar
Haycraft, C.J. et al. Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. PLoS Genet.1, e53 (2005). ArticlePubMedPubMed Central Google Scholar
Schneider, L. et al. PDGFRalphaalpha signaling is regulated through the primary cilium in fibroblasts. Curr. Biol.15, 1861–1866 (2005). ArticleCASPubMed Google Scholar
Lauth, M., Bergstrom, A. & Toftgard, R. Phorbol esters inhibit the Hedgehog signalling pathway downstream of Suppressor of Fused, but upstream of Gli. Oncogene26, 5163–5168 (2007). ArticleCASPubMed Google Scholar
Jin, K., Park, S., Ewton, D.Z. & Friedman, E. The survival kinase Mirk/Dyrk1B is a downstream effector of oncogenic K-ras in pancreatic cancer. Cancer Res.67, 7247–7255 (2007). ArticleCASPubMed Google Scholar
Mao, J. et al. Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1. J. Biol. Chem.277, 35156–35161 (2002). ArticleCASPubMed Google Scholar
Varjosalo, M. et al. Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling. Cell133, 537–548 (2008). ArticleCASPubMed Google Scholar
Heidenblad, M. et al. Genome-wide array-based comparative genomic hybridization reveals multiple amplification targets and novel homozygous deletions in pancreatic carcinoma cell lines. Cancer Res.64, 3052–3059 (2004). ArticleCASPubMed Google Scholar
Seeley, E.S., Carriere, C., Goetze, T., Longnecker, D.S. & Korc, M. Pancreatic cancer and precursor pancreatic intraepithelial neoplasia lesions are devoid of primary cilia. Cancer Res.69, 422–430 (2009). ArticleCASPubMedPubMed Central Google Scholar
Huangfu, D. et al. Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature426, 83–87 (2003). ArticleCASPubMed Google Scholar
Nolan-Stevaux, O. et al. GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation. Genes Dev.23, 24–36 (2009). ArticleCASPubMedPubMed Central Google Scholar
Dennler, S. et al. Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo. Cancer Res.67, 6981–6986 (2007). ArticleCASPubMed Google Scholar
Steg, A. et al. Hedgehog pathway expression in heterogeneous pancreatic adenocarcinoma: implications for the molecular analysis of clinically available biopsies. Diagn. Mol. Pathol.16, 229–237 (2007). ArticleCASPubMed Google Scholar
Nielsen, S.K. et al. Characterization of primary cilia and Hedgehog signaling during development of the human pancreas and in human pancreatic duct cancer cell lines. Dev. Dyn.237, 2039–2052 (2008). ArticleCASPubMed Google Scholar
Galvin, K.E., Ye, H., Erstad, D.J., Feddersen, R. & Wetmore, C. Gli1 induces G2/M arrest and apoptosis in hippocampal but not tumor-derived neural stem cells. Stem Cells26, 1027–1036 (2008). ArticleCASPubMed Google Scholar
Lauth, M. & Toftgard, R. Non-canonical activation of GLI transcription factors: implications for targeted anti-cancer therapy. Cell Cycle6, 2458–2463 (2007). ArticleCASPubMed Google Scholar
Kasai, K., Inaguma, S., Yoneyama, A., Yoshikawa, K. & Ikeda, H. SCL/TAL1 interrupting locus derepresses GLI1 from the negative control of suppressor-of-fused in pancreatic cancer cell. Cancer Res.68, 7723–7729 (2008). ArticleCASPubMed Google Scholar
Ji, Z., Mei, F.C., Xie, J. & Cheng, X. Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells. J. Biol. Chem.282, 14048–14055 (2007). ArticleCASPubMed Google Scholar
Tian, H. et al. Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis. Proc. Natl. Acad. Sci. USA106, 4254–4259 (2009). ArticleCASPubMedPubMed Central Google Scholar
Prasad, N.B. et al. Gene expression profiles in pancreatic intraepithelial neoplasia reflect the effects of Hedgehog signaling on pancreatic ductal epithelial cells. Cancer Res.65, 1619–1626 (2005). ArticleCASPubMed Google Scholar
Lauth, M., Bergstrom, A., Shimokawa, T. & Toftgard, R. Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc. Natl. Acad. Sci. USA104, 8455–8460 (2007). ArticleCASPubMedPubMed Central Google Scholar
Nakashima, H. et al. Nuclear factor-κB contributes to hedgehog signaling pathway activation through sonic hedgehog induction in pancreatic cancer. Cancer Res.66, 7041–7049 (2006). ArticleCASPubMed Google Scholar
Shimokawa, T. et al. Distinct roles of first exon variants of the tumor-suppressor Patched1 in Hedgehog signaling. Oncogene26, 4889–4896 (2007). ArticleCASPubMed Google Scholar
Ikram, M.S. et al. GLI2 is expressed in normal human epidermis and BCC and induces GLI1 expression by binding to its promoter. J. Invest. Dermatol.122, 1503–1509 (2004). ArticleCASPubMed Google Scholar