Structural dynamics in the gating ring of cyclic nucleotide–gated ion channels (original) (raw)

References

  1. Hille, B. Ion Channels of Excitable Membranes (Sinauer, Sunderland, Massachusetts, USA, 2001).
    Google Scholar
  2. Schreiber, M., Yuan, A. & Salkoff, L. Transplantable sites confer calcium sensitivity to BK channels. Nat. Neurosci. 2, 416–421 (1999).
    Article CAS Google Scholar
  3. Brauchi, S., Orta, G., Salazar, M., Rosenmann, E. & Latorre, R. A hot-sensing cold receptor: C-terminal domain determines thermosensation in transient receptor potential channels. J. Neurosci. 26, 4835–4840 (2006).
    Article CAS Google Scholar
  4. Craven, K.B. & Zagotta, W.N. CNG and HCN channels: two peas, one pod. Annu. Rev. Physiol. 68, 375–401 (2006).
    Article CAS Google Scholar
  5. Zagotta, W.N. et al. Structural basis for modulation and agonist specificity of HCN pacemaker channels. Nature 425, 200–205 (2003).
    Article CAS Google Scholar
  6. Selvin, P.R. Fluorescence resonance energy transfer. Methods Enzymol. 246, 300–334 (1995).
    Article CAS Google Scholar
  7. Vogel, S.S., Thaler, C. & Koushik, S.V. Fanciful FRET. Sci. STKE 2006, re2 (2006).
    PubMed Google Scholar
  8. Lakowicz, J.R. Principles of Fluorescence Spectroscopy (Plenum, New York, 1999).
    Book Google Scholar
  9. Zheng, J. & Zagotta, W.N. Gating rearrangements in cyclic nucleotide-gated channels revealed by patch-clamp fluorometry. Neuron 28, 369–374 (2000).
    Article CAS Google Scholar
  10. Zagotta, W.N. & Siegelbaum, S.A. Structure and function of cyclic nucleotide-gated channels. Annu. Rev. Neurosci. 19, 235–263 (1996).
    Article CAS Google Scholar
  11. Craven, K.B. & Zagotta, W.N. Salt bridges and gating in the COOH-terminal region of HCN2 and CNGA1 channels. J. Gen. Physiol. 124, 663–677 (2004).
    Article CAS Google Scholar
  12. Johnson, J.P., Jr & Zagotta, W.N. Rotational movement during cyclic nucleotide-gated channel opening. Nature 412, 917–921 (2001).
    Article CAS Google Scholar
  13. Hua, L. & Gordon, S.E. Functional interactions between A′ helices in the C-linker of open CNG channels. J. Gen. Physiol. 125, 335–344 (2005).
    Article CAS Google Scholar
  14. Matulef, K., Flynn, G.E. & Zagotta, W.N. Molecular rearrangements in the ligand-binding domain of cyclic nucleotide-gated channels. Neuron 24, 443–452 (1999).
    Article CAS Google Scholar
  15. Chanda, B., Asamoah, O.K., Blunck, R., Roux, B. & Bezanilla, F. Gating charge displacement in voltage-gated ion channels involves limited transmembrane movement. Nature 436, 852–856 (2005).
    Article CAS Google Scholar
  16. Islas, L.D. & Zagotta, W.N. Short-range molecular rearrangements in ion channels detected by tryptophan quenching of bimane fluorescence. J. Gen. Physiol. 128, 337–346 (2006).
    Article CAS Google Scholar
  17. Gordon, S.E., Varnum, M.D. & Zagotta, W.N. Direct interaction between amino- and carboxyl-terminal domains of cyclic nucleotide-gated channels. Neuron 19, 431–441 (1997).
    Article CAS Google Scholar
  18. Brown, R.L., Snow, S.D. & Haley, T.L. Movement of gating machinery during the activation of rod cyclic nucleotide-gated channels. Biophys. J. 75, 825–833 (1998).
    Article CAS Google Scholar
  19. Chanda, B. et al. A hybrid approach to measuring electrical activity in genetically specified neurons. Nat. Neurosci. 8, 1619–1626 (2005).
    Article CAS Google Scholar
  20. Fernandez, J.M., Taylor, R.E. & Bezanilla, F. Induced capacitance in the squid giant axon. Lipophilic ion displacement currents. J. Gen. Physiol. 82, 331–346 (1983).
    Article CAS Google Scholar
  21. Inouye, S. & Tsuji, F.I. Evidence for redox forms of the Aequorea green fluorescent protein. FEBS Lett. 351, 211–214 (1994).
    Article CAS Google Scholar
  22. Ostergaard, H., Henriksen, A., Hansen, F.G. & Winther, J.R. Shedding light on disulfide bond formation: engineering a redox switch in green fluorescent protein. EMBO J. 20, 5853–5862 (2001).
    Article CAS Google Scholar
  23. Zheng, J., Varnum, M.D. & Zagotta, W.N. Disruption of an intersubunit interaction underlies Ca2+-calmodulin modulation of cyclic nucleotide-gated channels. J. Neurosci. 23, 8167–8175 (2003).
    Article CAS Google Scholar
  24. Wainger, B.J., DeGennaro, M., Santoro, B., Siegelbaum, S.A. & Tibbs, G.R. Molecular mechanism of cAMP modulation of HCN pacemaker channels. Nature 411, 805–810 (2001).
    Article CAS Google Scholar
  25. Vemana, S., Pandey, S. & Larsson, H.P. S4 movement in a mammalian HCN channel. J. Gen. Physiol. 123, 21–32 (2004).
    Article CAS Google Scholar
  26. Ye, S., Li, Y., Chen, L. & Jiang, Y. Crystal structures of a ligand-free MthK gating ring: insights into the ligand gating mechanism of K+ channels. Cell 126, 1161–1173 (2006).
    Article CAS Google Scholar
  27. Jiang, Y. et al. Crystal structure and mechanism of a calcium-gated potassium channel. Nature 417, 515–522 (2002).
    Article CAS Google Scholar
  28. Popovych, N., Sun, S., Ebright, R.H. & Kalodimos, C.G. Dynamically driven protein allostery. Nat. Struct. Mol. Biol. 13, 831–838 (2006).
    Article CAS Google Scholar
  29. Cordero-Morales, J.F. et al. Molecular determinants of gating at the potassium-channel selectivity filter. Nat. Struct. Mol. Biol. 13, 311–318 (2006).
    Article CAS Google Scholar
  30. Kaupp, U.B. et al. Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel. Nature 342, 762–766 (1989).
    Article CAS Google Scholar
  31. Gordon, S.E. & Zagotta, W.N. A histidine residue associated with the gate of the cyclic nucleotide-activated channels in rod photoreceptors. Neuron 14, 177–183 (1995).
    Article CAS Google Scholar
  32. Hamill, O.P., Marty, A., Neher, E., Sakmann, B. & Sigworth, F.J. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch. 391, 85–100 (1981).
    Article CAS Google Scholar
  33. Cha, A. & Bezanilla, F. Structural implications of fluorescence quenching in the Shaker K+ channel. J. Gen. Physiol. 112, 391–408 (1998).
    Article CAS Google Scholar
  34. Wolber, P.K. & Hudson, B.S. An analytic solution to the Forster energy transfer problem in two dimensions. Biophys. J. 28, 197–210 (1979).
    Article CAS Google Scholar
  35. Flynn, G.E. & Zagotta, W.N. Conformational changes in S6 coupled to the opening of cyclic nucleotide-gated channels. Neuron 30, 689–698 (2001).
    Article CAS Google Scholar
  36. Guex, N. & Peitsch, M.C. SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. Electrophoresis 18, 2714–2723 (1997).
    Article CAS Google Scholar
  37. Long, S.B., Campbell, E.B. & Mackinnon, R. Crystal structure of a mammalian voltage-dependent Shaker family K+ channel. Science 309, 897–903 (2005).
    Article CAS Google Scholar

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