Closed state of both binding domains of homodimeric mGlu receptors is required for full activity (original) (raw)

• Cho, H.S. & Leahy, D.J. Structure of the extracellular region of HER3 reveals an interdomain tether. Science 297, 1330–1333 (2002).
  Article CAS PubMed Google Scholar
• Cho, H.S. et al. Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab. Nature 421, 756–760 (2003).
  Article CAS PubMed Google Scholar
• Ogiso, H. et al. Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains. Cell 110, 775–787 (2002).
  Article CAS PubMed Google Scholar
• Ferguson, K.M. et al. EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization. Mol. Cell 11, 507–517 (2003).
  Article CAS PubMed Google Scholar
• He, X.-L., Chow, D.-C., Martick, M.M. & Garcia, K.C. Allosteric activation of a spring-loaded natriuretic peptide receptor dimer by hormone. Science 293, 1657–1662 (2001).
  Article CAS Google Scholar
• van den Akker, F. et al. Structure of the dimerized hormone-binding domain of a guanylyl-cyclase-coupled receptor. Nature 406, 101–104 (2000).
  Article CAS PubMed Google Scholar
• van den Akker, F. Structural insights into the ligand binding domains of membrane bound guanylyl cyclases and natriuretic peptide receptors. J. Mol. Biol. 311, 923–937 (2001).
  Article CAS PubMed Google Scholar
• Tsuchiya, D., Kunishima, N., Kamiya, N., Jingami, H. & Morikawa, K. Structural views of the ligand-binding cores of a metabotropic glutamate receptor complexed with an antagonist and both glutamate and Gd3+. Proc. Natl. Acad. Sci. USA 99, 2660–2665 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Kunishima, N. et al. Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor. Nature 407, 971–977 (2000).
  Article CAS PubMed Google Scholar
• Dann, C.E. et al. Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains. Nature 412, 86–90 (2001).
  Article CAS PubMed Google Scholar
• West, A.P., Jr., Llamas, L.L., Snow, P.M., Benzer, S. & Bjorkman, P.J. Crystal structure of the ectodomain of Methuselah, a Drosophila G protein-coupled receptor associated with extended lifespan. Proc. Natl. Acad. Sci. USA 98, 3744–3749 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Pin, J.P., Galvez, T. & Prezeau, L. Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors. Pharmacol. Ther. 98, 325–354 (2003).
  Article CAS PubMed Google Scholar
• O'Hara, P.J. et al. The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins. Neuron 11, 41–52 (1993).
  Article CAS PubMed Google Scholar
• Romano, C., Yang, W.L. & O'Malley, K.L. Metabotropic glutamate receptor 5 is a disulfide-linked dimer. J. Biol. Chem. 271, 28612–28616 (1996).
  Article CAS PubMed Google Scholar
• Kniazeff, J. et al. Locking the dimeric GABAB G-protein-coupled receptor in its active state. J. Neurosci. 24, 370–377 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Bessis, A.S. et al. Closure of the Venus flytrap module of mGlu8 receptor and the activation process: Insights from mutations converting antagonists into agonists. Proc. Natl. Acad. Sci. USA 99, 11097–11102 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Kniazeff, J., Galvez, T., Labesse, G. & Pin, J.P. No ligand binding in the GB2 subunit of the GABAB receptor is required for activation and allosteric interaction between the subunits. J. Neurosci. 22, 7352–7361 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Margeta-Mitrovic, M., Jan, Y.N. & Jan, L.Y. A trafficking checkpoint controls GABAB receptor heterodimerization. Neuron 27, 97–106 (2000).
  Article CAS PubMed Google Scholar
• Pagano, A. et al. C-terminal interaction is essential for surface trafficking but not for heteromeric assembly of GABAB receptors. J. Neurosci. 21, 1189–1202 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Couve, A. et al. Intracellular retention of recombinant GABAB receptors. J. Biol. Chem. 273, 26361–26367 (1998).
  Article CAS PubMed Google Scholar
• Ray, K. & Hauschild, B.C. Cys-140 Is critical for metabotropic glutamate receptor-1 (mGluR-1) dimerization. J. Biol. Chem. 275, 34245–34251 (2000).
  Article CAS PubMed Google Scholar
• Tsuji, Y. et al. Cryptic dimer interface and domain organization of the extracellular region of metabotropic glutamate receptor subtype 1. J. Biol. Chem. 275, 28144–28151 (2000).
  CAS PubMed Google Scholar
• Bazin, H., Trinquet, E. & Mathis, G. Time resolved amplification of cryptate emission: a versatile technology to trace biomolecular interactions. Rev. Mol. Biotech. 82, 233–250 (2002).
  Article CAS Google Scholar
• Maurel, D. et al. Cell surface detection of membrane protein interaction with HTRF technology. Anal. Biochem. 329, 253–262 (2004).
  Article CAS PubMed Google Scholar
• Goudet, C. et al. Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors. Proc. Natl. Acad. Sci. USA 101, 378–383 (2004).
  Article CAS PubMed Google Scholar
• Pin, J.-P. & Acher, F. The metabotropic glutamate receptors: structure, activation mechanism and pharmacology. Curr. Drug Targets CNS Neurol. Disord. 1, 297–317 (2002).
  Article CAS PubMed Google Scholar
• Havlickova, M. et al. The intracellular loops of the GB2 subunit are crucial for G-protein coupling of the heteromeric γ-aminobutyrate B receptor. Mol. Pharmacol. 62, 343–350 (2002).
  Article CAS PubMed Google Scholar
• Chang, W., Chen, T.H., Pratt, S. & Shoback, D. Amino acids in the second and third intracellular loops of the parathyroid Ca2+-sensing receptor mediate efficient coupling to phospholipase C. J. Biol. Chem. 275, 19955–19963 (2000).
  Article CAS PubMed Google Scholar
• Francesconi, A. & Duvoisin, R.M. Role of the second and third intracellular loops of metabotropic glutamate receptors in mediating dual signal transduction activation. J. Biol. Chem. 273, 5615–5624 (1998).
  Article CAS PubMed Google Scholar
• Galvez, T. et al. Mapping the agonist binding site of GABAB type 1 subunit sheds light on the activation process of GABAB receptors. J. Biol. Chem. 275, 41166–41174 (2000).
  Article CAS PubMed Google Scholar
• Marshall, F.H., Jones, K.A., Kaupmann, K. & Bettler, B. GABAB receptors—the first 7TM heterodimers. Trends Pharmacol. Sci. 20, 396–399 (1999).
  Article CAS PubMed Google Scholar
• Galvez, T. et al. Allosteric interactions between GB1 and GB2 subunits are required for optimal GABAB receptor function. EMBO J. 20, 2152–2159 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Duthey, B. et al. A single subunit (GB2) is required for G-protein activation by the heterodimeric GABAB receptor. J. Biol. Chem. 277, 3236–3241 (2002).
  Article CAS PubMed Google Scholar
• Pin, J.-P. & Bockaert, J. Part IV: type III family of GPCRs—metabotropic glutamate receptors. In Structure-Function of G-protein Coupled Receptors in the CNS (eds. Pangalos, M. & Davies, C.) 586–616 (Oxford Univ. Press, Oxford, 2002).
  Google Scholar
• Kubo, Y., Miyashita, T. & Murata, Y. Structural basis for a Ca2+-sensing function of the metabotropic glutamate receptors. Science 279, 1722–1725 (1998).
  Article CAS PubMed Google Scholar
• Nelson, G. et al. Mammalian sweet taste receptors. Cell 106, 381–390 (2001).
  Article CAS PubMed Google Scholar
• Li, X. et al. Human receptors for sweet and umami taste. Proc. Natl. Acad. Sci. USA 99, 4692–4696 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Zhao, G.Q. et al. The receptors for mammalian sweet and umami taste. Cell 115, 255–266 (2003).
  Article CAS PubMed Google Scholar
• Nelson, G. et al. An amino-acid taste receptor. Nature 416, 199–202 (2002).
  Article CAS PubMed Google Scholar
• Ango, F. et al. A simple method to transfer plasmid DNA into neuronal primary cultures: functional expression of the mGlu5 receptor in cerebellar granule cells. Neuropharmacology 38, 793–803 (1999).
  Article CAS PubMed Google Scholar
• Brabet, I. et al. Comparative effect of L-CCG-I, DCG-IV and γ-carboxy-L-glutamate on all cloned metabotropic glutamate receptor subtypes. Neuropharmacology 37, 1043–1051 (1998).
  Article CAS PubMed Google Scholar
• Guex, N. & Peitsch, M.C. SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. Electrophoresis 18, 2714–2723 (1997).
  Article CAS PubMed Google Scholar