Notch3: from subtle structural differences to functional diversity (original) (raw)
Anastasi E, Campese AF, Bellavia D, Bulotta A, Balestri A, Pascucci M et al. (2003). Expression of activated Notch3 in transgenic mice enhances generation of T regulatory cells and protects against experimental autoimmune diabetes. J Immunol171: 4504–4511. ArticleCASPubMed Google Scholar
Artavanis-Tsakonas S, Rand MD, Lake RJ . (1999). Notch signaling: cell fate control and signal integration in development. Science284: 770–776. ArticleCASPubMed Google Scholar
Ascano JM, Beverly LJ, Capobianco AJ . (2003). The C-terminal PDZ-ligand of JAGGED1 is essential for cellular transformation. J Biol Chem278: 8771–8779. ArticleCASPubMed Google Scholar
Austin J, Kimble J . (1989). Transcript analysis of glp-1 and lin-12, homologous genes required for cell interactions during development of C. elegans. Cell58: 565–571. ArticleCASPubMed Google Scholar
Barrick D, Kopan R . (2006). The Notch transcription activation complex makes its move. Cell124: 883–885. ArticleCASPubMed Google Scholar
Beatus P, Lundkvist J, Oberg C, Pedersen K, Lendahl U . (2001). The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity. Mech Dev104: 3–20. ArticleCASPubMed Google Scholar
Bellavia D, Campese AF, Alesse E, Vacca A, Felli MP, Balestri A et al. (2000). Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice. EMBO J19: 3337–3348. ArticleCASPubMedPubMed Central Google Scholar
Bellavia D, Campese AF, Checquolo S, Balestri A, Biondi A, Cazzaniga G et al. (2002). Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis. Proc Natl Acad Sci USA99: 3788–3793. ArticleCASPubMedPubMed Central Google Scholar
Bellavia D, Mecarozzi M, Campese AF, Grazioli P, Talora C, Frati L et al. (2007). Notch3 and the Notch3-upregulated RNA-binding protein HuD regulate Ikaros alternative splicing. EMBO J26: 1670–1680. ArticleCASPubMedPubMed Central Google Scholar
Beverly LJ, Capobianco AJ . (2003). Perturbation of Ikaros isoform selection by MLV integration is a cooperative event in Notch(IC)-induced T cell leukemogenesis. Cancer Cell3: 551–564. ArticleCASPubMed Google Scholar
Bray SJ . (2006). Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol7: 678–689. ArticleCASPubMed Google Scholar
Brou C, Logeat F, Gupta N, Bessia C, LeBail O, Doedens JR et al. (2000). A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE. Mol Cell5: 207–216. ArticleCASPubMed Google Scholar
Cemerski S, Shaw A . (2006). Immune synapses in T-cell activation. Curr Opin Immunol18: 298–304. ArticleCASPubMed Google Scholar
Christensen S, Kodoyianni V, Bosenberg M, Friedman L, Kimble J . (1996). lag-1, a gene required for lin-12 and glp-1 signaling in Caenorhabditis elegans, is homologous to human CBF1 and Drosophila Su(H). Development122: 1373–1383. CASPubMed Google Scholar
Dang TP, Eichenberger S, Gonzalez A, Olson S, Carbone DP . (2003). Constitutive activation of Notch3 inhibits terminal epithelial differentiation in lungs of transgenic mice. Oncogene22: 1988–1997. ArticleCASPubMed Google Scholar
De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS et al. (1999). A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature398: 518–522. ArticleCASPubMed Google Scholar
Domenga V, Fardoux P, Lacombe P, Monet M, Maciazek J, Krebs LT et al. (2004). Notch3 is required for arterial identity and maturation of vascular smooth muscle cells. Genes Dev18: 2730–2735. ArticleCASPubMedPubMed Central Google Scholar
Felli MP, Maroder M, Mitsiadis TA, Campese AF, Bellavia D, Vacca A et al. (1999). Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development. Int Immunol11: 1017–1025. ArticleCASPubMed Google Scholar
Felli MP, Vacca A, Calce A, Bellavia D, Campese AF, Grillo R et al. (2005). PKC theta mediates pre-TCR signaling and contributes to Notch3-induced T-cell leukemia. Oncogene24: 992–1000. ArticleCASPubMed Google Scholar
Fitzgerald K, Wilkinson HA, Greenwald I . (1993). glp-1 can substitute for lin-12 in specifying cell fate decisions in Caenorhabditis elegans. Development119: 1019–1027. CASPubMed Google Scholar
Fortini ME, Artavanis-Tsakonas S . (1994). The suppressor of hairless protein participates in notch receptor signaling. Cell79: 273–282. ArticleCASPubMed Google Scholar
Gale NW, Dominguez MG, Noguera I, Pan L, Hughes V, Valenzuela DM et al. (2004). Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development. Proc Natl Acad Sci USA101: 15949–15954. ArticleCASPubMedPubMed Central Google Scholar
Hamada Y, Kadokawa Y, Okabe M, Ikawa M, Coleman JR, Tsujimoto Y . (1999). Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic lethality. Development126: 3415–3424. CASPubMed Google Scholar
Hrabe de Angelis M, McIntyre II J, Gossler A . (1997). Maintenance of somite borders in mice requires the Delta homologue DII1. Nature386: 717–721. ArticleCASPubMed Google Scholar
Ikeuchi T, Sisodia SS . (2003). The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent ‘gamma-secretase’ cleavage. J Biol Chem278: 7751–7754. ArticleCASPubMed Google Scholar
Joutel A, Andreux F, Gaulis S, Domenga V, Cecillon M, Battail N et al. (2000). The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients. J Clin Invest105: 597–605. ArticleCASPubMedPubMed Central Google Scholar
Joutel A, Corpechot C, Ducros A, Vahedi K, Chabriat H, Mouton P et al. (1996). Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia. Nature383: 707–710. ArticleCASPubMed Google Scholar
Konishi J, Kawaguchi KS, Vo H, Haruki N, Gonzalez A, Carbone DP et al. (2007). Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers. Cancer Res67: 8051–8057. ArticleCASPubMed Google Scholar
Kopan R, Weintraub H . (1993). Mouse notch: expression in hair follicles correlates with cell fate determination. J Cell Biol121: 631–641. ArticleCASPubMed Google Scholar
Kovall RA . (2007). Structures of CSL, Notch and Mastermind proteins: piecing together an active transcription complex. Curr Opin Struct Biol17: 117–127. ArticleCASPubMed Google Scholar
Kurooka H, Kuroda K, Honjo T . (1998). Roles of the ankyrin repeats and C-terminal region of the mouse notch1 intracellular region. Nucleic Acids Res26: 5448–5455. ArticleCASPubMedPubMed Central Google Scholar
Lacombe P, Oligo C, Domenga V, Tournier-Lasserve E, Joutel A . (2005). Impaired cerebral vasoreactivity in a transgenic mouse model of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy arteriopathy. Stroke36: 1053–1058. ArticlePubMed Google Scholar
Lardelli M, Dahlstrand J, Lendahl U . (1994). The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium. Mech Dev46: 123–136. ArticleCASPubMed Google Scholar
LaVoie MJ, Selkoe DJ . (2003). The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments. J Biol Chem278: 34427–34437. ArticleCASPubMed Google Scholar
Li K, Li Y, Wu W, Gordon WR, Chang DW, Lu M et al. (2008). Modulation of notch signaling by antibodies specific for the extracellular negative regulatory region of Notch3. J Biol Chem283: 8046–8054. ArticleCASPubMed Google Scholar
Li Y, Baker NE . (2004). The roles of _cis_-inactivation by Notch ligands and of neuralized during eye and bristle patterning in Drosophila. BMC Dev Biol4: 5. ArticleCASPubMedPubMed Central Google Scholar
Lubman OY, Ilagan MX, Kopan R, Barrick D . (2007). Quantitative dissection of the Notch:CSL interaction: insights into the Notch-mediated transcriptional switch. J Mol Biol365: 577–589. ArticleCASPubMed Google Scholar
Monet M, Domenga V, Lemaire B, Souilhol C, Langa F, Babinet C et al. (2007). The archetypal R90C CADASIL-NOTCH3 mutation retains NOTCH3 function in vivo. Hum Mol Genet16: 982–992. ArticleCASPubMed Google Scholar
Nam Y, Sliz P, Song L, Aster JC, Blacklow SC . (2006). Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell124: 973–983. ArticleCASPubMed Google Scholar
Nehring LC, Miyamoto A, Hein PW, Weinmaster G, Shipley JM . (2005). The extracellular matrix protein MAGP-2 interacts with Jagged1 and induces its shedding from the cell surface. J Biol Chem280: 20349–20355. ArticleCASPubMed Google Scholar
Ong CT, Cheng HT, Chang LW, Ohtsuka T, Kageyama R, Stormo GD et al. (2006). Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability. J Biol Chem281: 5106–5119. ArticleCASPubMed Google Scholar
Park JT, Li M, Nakayama K, Mao TL, Davidson B, Zhang Z et al. (2006). Notch3 gene amplification in ovarian cancer. Cancer Res66: 6312–6318. ArticleCASPubMed Google Scholar
Petcherski AG, Kimble J . (2000). Mastermind is a putative activator for Notch. Curr Biol10: R471–R473. ArticleCASPubMed Google Scholar
Qi H, Rand MD, Wu X, Sestan N, Wang W, Rakic P et al. (1999). Processing of the notch ligand delta by the metalloprotease Kuzbanian. Science283: 91–94. ArticleCASPubMed Google Scholar
Sakamoto K, Ohara O, Takagi M, Takeda S, Katsube K . (2002). Intracellular cell-autonomous association of Notch and its ligands: a novel mechanism of Notch signal modification. Dev Biol241: 313–326. ArticleCASPubMed Google Scholar
Sansone P, Storci G, Giovannini C, Pandolfi S, Pianetti S, Taffurelli M et al. (2007a). p66Shc/Notch-3 interplay controls self-renewal and hypoxia survival in human stem/progenitor cells of the mammary gland expanded in vitro as mammospheres. Stem Cells25: 807–815. ArticleCASPubMed Google Scholar
Sansone P, Storci G, Tavolari S, Guarnieri T, Giovannini C, Taffurelli M et al. (2007b). IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland. J Clin Invest117: 3988–4002. ArticleCASPubMedPubMed Central Google Scholar
Shah S, Lee SF, Tabuchi K, Hao YH, Yu C, LaPlant Q et al. (2005). Nicastrin functions as a gamma-secretase-substrate receptor. Cell122: 435–447. ArticleCASPubMed Google Scholar
Shimizu K, Chiba S, Kumano K, Hosoya N, Takahashi T, Kanda Y et al. (1999). Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods. J Biol Chem274: 32961–32969. ArticleCASPubMed Google Scholar
Swiatek PJ, Lindsell CE, del Amo FF, Weinmaster G, Gridley T . (1994). Notch1 is essential for postimplantation development in mice. Genes Dev8: 707–719. ArticleCASPubMed Google Scholar
Talora C, Campese AF, Bellavia D, Pascucci M, Checquolo S, Groppioni M et al. (2003). Pre-TCR-triggered ERK signalling-dependent downregulation of E2A activity in Notch3-induced T-cell lymphoma. EMBO Rep4: 1067–1072. ArticleCASPubMedPubMed Central Google Scholar
Tamura K, Taniguchi Y, Minoguchi S, Sakai T, Tun T, Furukawa T et al. (1995). Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H). Curr Biol5: 1416–1423. ArticleCASPubMed Google Scholar
Vacca A, Felli MP, Palermo R, Di Mario G, Calce A, Di Giovine M et al. (2006). Notch3 and pre-TCR interaction unveils distinct NF-kappaB pathways in T-cell development and leukemia. EMBO J25: 1000–1008. ArticleCASPubMedPubMed Central Google Scholar
Varnum-Finney B, Purton LE, Yu M, Brashem-Stein C, Flowers D, Staats S et al. (1998). The Notch ligand, Jagged-1, influences the development of primitive hematopoietic precursor cells. Blood91: 4084–4091. CASPubMed Google Scholar
Voll RE, Jimi E, Phillips RJ, Barber DF, Rincon M, Hayday AC et al. (2000). NF-kappa B activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development. Immunity13: 677–689. ArticleCASPubMed Google Scholar
von Boehmer H, Aifantis I, Azogui O, Feinberg J, Saint-Ruf C, Zober C et al. (1998). Crucial function of the pre-T-cell receptor (TCR) in TCR beta selection, TCR beta allelic exclusion and alpha beta versus gamma delta lineage commitment. Immunol Rev165: 111–119. ArticleCASPubMed Google Scholar
Vooijs M, Schroeter EH, Pan Y, Blandford M, Kopan R . (2004). Ectodomain shedding and intramembrane cleavage of mammalian Notch proteins is not regulated through oligomerization. J Biol Chem279: 50864–50873. ArticleCASPubMed Google Scholar
Weinmaster G, Roberts VJ, Lemke G . (1991). A homolog of Drosophila Notch expressed during mammalian development. Development113: 199–205. CASPubMed Google Scholar
Weinmaster G, Roberts VJ, Lemke G . (1992). Notch2: a second mammalian Notch gene. Development116: 931–941. CASPubMed Google Scholar
Wharton KA, Johansen KM, Xu T, Artavanis-Tsakonas S . (1985). Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats. Cell43: 567–581. ArticleCASPubMed Google Scholar
Wilson JJ, Kovall RA . (2006). Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA. Cell124: 985–996. ArticleCASPubMed Google Scholar
Winandy S, Wu P, Georgopoulos K . (1995). A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma. Cell83: 289–299. ArticleCASPubMed Google Scholar
Wu J, Bresnick EH . (2007). Bare rudiments of notch signaling: how receptor levels are regulated. Trends Biochem Sci32: 477–485. ArticleCASPubMed Google Scholar
Xue Y, Gao X, Lindsell CE, Norton CR, Chang B, Hicks C et al. (1999). Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1. Hum Mol Genet8: 723–730. ArticleCASPubMed Google Scholar
Zhang Y, Jia L, Lee SJ, Wang MM . (2007). Conserved signal peptide of Notch3 inhibits interaction with proteasome. Biochem Biophys Res Commun355: 245–251. ArticleCASPubMedPubMed Central Google Scholar