FEN1 contributes to telomere stability in ALT-positive tumor cells (original) (raw)
Artandi SE, DePinho RA . (2000). A critical role for telomeres in suppressing and facilitating carcinogenesis. Curr Opin Genet Dev10: 39–46. ArticleCAS Google Scholar
Blasco MA . (2005). Telomeres and human disease: ageing, cancer and beyond. Nat Rev Genet6: 611–622. ArticleCAS Google Scholar
Branzei D, Foiani M . (2005). The DNA damage response during DNA replication. Curr Opin Cell Biol17: 568–575. ArticleCAS Google Scholar
Bryan TM, Englezou A, Dalla-Pozza L, Dunham MA, Reddel RR . (1997). Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines. Nat Med3: 1271–1274. ArticleCAS Google Scholar
Crabbe L, Verdun RE, Haggblom CI, Karlseder J . (2004). Defective telomere lagging strand synthesis in cells lacking WRN helicase activity. Science306: 1951–1953. ArticleCAS Google Scholar
d’Adda di Fagagna F, Reaper PM, Clay-Farrace L, Fiegler H, Carr P, Von Zglinicki T et al. (2003). A DNA damage checkpoint response in telomere-initiated senescence. Nature426: 194–198. Article Google Scholar
de Lange T . (2005). Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev19: 2100–2110. ArticleCAS Google Scholar
Forstemann K, Hoss M, Lingner J . (2000). Telomerase-dependent repeat divergence at the 3′ ends of yeast telomeres. Nucleic Acids Res28: 2690–2694. ArticleCAS Google Scholar
Fouche N, Ozgur S, Roy D, Griffith JD . (2006). Replication fork regression in repetitive DNAs. Nucleic Acids Res34: 6044–6050. ArticleCAS Google Scholar
Gilson E, Geli V . (2007). How telomeres are replicated. Nat Rev Mol Cell Biol8: 825–838. ArticleCAS Google Scholar
Grobelny JV, Kulp-McEliece M, Broccoli D . (2001). Effects of reconstitution of telomerase activity on telomere maintenance by the alternative lengthening of telomeres (ALT) pathway. Hum Mol Genet10: 1953–1961. ArticleCAS Google Scholar
Hahn WC, Stewart SA, Brooks MW, York SG, Eaton E, Kurachi A et al. (1999). Inhibition of telomerase limits the growth of human cancer cells. Nat Med5: 1164–1170. ArticleCAS Google Scholar
Hemann MT, Strong MA, Hao LY, Greider CW . (2001). The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell107: 67–77. ArticleCAS Google Scholar
Kikuchi K, Taniguchi Y, Hatanaka A, Sonoda E, Hochegger H, Adachi N et al. (2005). Fen-1 facilitates homologous recombination by removing divergent sequences at DNA break ends. Mol Cell Biol25: 6948–6955. ArticleCAS Google Scholar
Kucherlapati M, Nguyen A, Kuraguchi M, Yang K, Fan K, Bronson R et al. (2007). Tumor progression in Apc(1638N) mice with Exo1 and Fen1 deficiencies. Oncogene26: 6297–6306. ArticleCAS Google Scholar
Li X, Li J, Harrington J, Lieber MR, Burgers PM . (1995). Lagging strand DNA synthesis at the eukaryotic replication fork involves binding and stimulation of FEN-1 by proliferating cell nuclear antigen. J Biol Chem270: 22109–22112. ArticleCAS Google Scholar
Liu D, O’Connor MS, Qin J, Songyang Z . (2004). Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins. J Biol Chem279: 51338–51342. ArticleCAS Google Scholar
Londono-Vallejo JA, Der-Sarkissian H, Cazes L, Bacchetti S, Reddel RR . (2004). Alternative lengthening of telomeres is characterized by high rates of telomeric exchange. Cancer Res64: 2324–2327. ArticleCAS Google Scholar
Marcand S, Brevet V, Gilson E . (1999). Progressive cis-inhibition of telomerase upon telomere elongation. Embo J18: 3509–3519. ArticleCAS Google Scholar
Nabetani A, Yokoyama O, Ishikawa F . (2004). Localization of hRad9, hHus1, hRad1, and hRad17 and caffeine-sensitive DNA replication at the alternative lengthening of telomeres-associated promyelocytic leukemia body. J Biol Chem279: 25849–25857. ArticleCAS Google Scholar
Ohki R, Ishikawa F . (2004). Telomere-bound TRF1 and TRF2 stall the replication fork at telomeric repeats. Nucleic Acids Res32: 1627–1637. ArticleCAS Google Scholar
Ouellette MM, Liao M, Herbert BS, Johnson M, Holt SE, Liss HS et al. (2000). Subsenescent telomere lengths in fibroblasts immortalized by limiting amounts of telomerase. J Biol Chem275: 10072–10076. ArticleCAS Google Scholar
Parenteau J, Wellinger RJ . (1999). Accumulation of single-stranded DNA and destabilization of telomeric repeats in yeast mutant strains carrying a deletion of RAD27. Mol Cell Biol19: 4143–4152. ArticleCAS Google Scholar
Parenteau J, Wellinger RJ . (2002). Differential processing of leading- and lagging-strand ends at Saccharomyces cerevisiae telomeres revealed by the absence of Rad27p nuclease. Genetics162: 1583–1594. CASPubMedPubMed Central Google Scholar
Perrem K, Colgin LM, Neumann AA, Yeager TR, Reddel RR . (2001). Coexistence of alternative lengthening of telomeres and telomerase in hTERT-transfected GM847 cells. Mol Cell Biol21: 3862–3875. ArticleCAS Google Scholar
Prasad R, Dianov GL, Bohr VA, Wilson SH . (2000). FEN1 stimulation of DNA polymerase beta mediates an excision step in mammalian long patch base excision repair. J Biol Chem275: 4460–4466. ArticleCAS Google Scholar
Saharia A, Guittat L, Crocker S, Lim A, Steffen M, Kulkarni S et al. (2008). Flap endonuclease 1 contributes to telomere stability. Curr Biol18: 496–500. ArticleCAS Google Scholar
Sharma S, Otterlei M, Sommers JA, Driscoll HC, Dianov GL, Kao HI et al. (2004). WRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication fork. Mol Biol Cell15: 734–750. ArticleCAS Google Scholar
Stewart SA, Ben-Porath I, Carey VJ, O’Connor BF, Hahn WC, Weinberg RA . (2003). Erosion of the telomeric single-strand overhang at replicative senescence. Nat Genet33: 492–496. ArticleCAS Google Scholar
Stewart SA, Hahn WC, O’Connor BF, Banner EN, Lundberg AS, Modha P et al. (2002). Telomerase contributes to tumorigenesis by a telomere length-independent mechanism. Proc Natl Acad Sci USA99: 12606–12611. ArticleCAS Google Scholar
Takai H, Smogorzewska A, de Lange T . (2003). DNA damage foci at dysfunctional telomeres. Curr Biol13: 1549–1556. ArticleCAS Google Scholar
Teixeira MT, Arneric M, Sperisen P, Lingner J . (2004). Telomere length homeostasis is achieved via a switch between telomerase- extendible and -nonextendible states. Cell117: 323–335. ArticleCAS Google Scholar
Tishkoff DX, Filosi N, Gaida GM, Kolodner RD . (1997). A novel mutation avoidance mechanism dependent on S. cerevisiae RAD27 is distinct from DNA mismatch repair. Cell88: 253–263. ArticleCAS Google Scholar
Zheng L, Dai H, Zhou M, Li M, Singh P, Qiu J et al. (2007). Fen1 mutations result in autoimmunity, chronic inflammation and cancers. Nat Med13: 812–819. ArticleCAS Google Scholar
Zheng L, Zhou M, Chai Q, Parrish J, Xue D, Patrick SM et al. (2005). Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks. EMBO Rep6: 83–89. ArticleCAS Google Scholar