- Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D . Global cancer statistics. CA 2011; 61: 69–90.
PubMed Google Scholar
- Valastyan S, Weinberg RA . Tumor metastasis: molecular insights and evolving paradigms. Cell 2011; 147: 275–292.
Article CAS PubMed PubMed Central Google Scholar
- Fidler IJ . The pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisited. Nat Rev Cancer 2003; 3: 453–458.
Article CAS PubMed Google Scholar
- Jemal A, Siegel R, Xu J, Ward E . Cancer statistics. CA 2010; 60: 277–300.
PubMed Google Scholar
- Chaffer CL, Weinberg RA . A perspective on cancer cell metastasis. Science 2011; 331: 1559–1564.
Article CAS PubMed Google Scholar
- Nicoloso MS, Spizzo R, Shimizu M, Rossi S, Calin GA . MicroRNAs–the micro steering wheel of tumour metastases. Nat Rev Cancer 2009; 9: 293–302.
Article CAS PubMed Google Scholar
- Ambros V . MicroRNAs: tiny regulators with great potential. Cell 2001; 107: 823–826.
Article CAS PubMed Google Scholar
- Schickel R, Boyerinas B, Park SM, Peter ME . MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death. Oncogene 2008; 27: 5959–5974.
Article CAS PubMed Google Scholar
- Calin GA, Croce CM . MicroRNA signatures in human cancers. Nat Rev Cancer 2006; 6: 857–866.
Article CAS PubMed Google Scholar
- Tavazoie SF, Alarcon C, Oskarsson T, Padua D, Wang Q, Bos PD et al. Endogenous human microRNAs that suppress breast cancer metastasis. Nature 2008; 451: 147–152.
Article CAS PubMed PubMed Central Google Scholar
- Calin GA, Sevignani C, Dumitru CD, Hyslop T, Noch E, Yendamuri S et al. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci USA 2004; 101: 2999–3004.
Article CAS PubMed PubMed Central Google Scholar
- Asangani IA, Rasheed SA, Nikolova DA, Leupold JH, Colburn NH, Post S et al. MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 2008; 27: 2128–2136.
Article CAS PubMed Google Scholar
- Wang L, Wang J . MicroRNA-mediated breast cancer metastasis: from primary site to distant organs. Oncogene 2012; 31: 2499–2511.
Article CAS PubMed Google Scholar
- Agrawal R, Tran U, Wessely O . The miR-30 miRNA family regulates xenopus pronephros development and targets the transcription factor Xlim1/Lhx1. Development 2009; 136: 3927–3936.
Article CAS PubMed PubMed Central Google Scholar
- Martinez I, Cazalla D, Almstead LL, Steitz JA, DiMaio D . miR-29 and miR-30 regulate B-Myb expression during cellular senescence. Proc Natl Acad Sci USA 2011; 108: 522–527.
Article CAS PubMed Google Scholar
- Xia Z, Zhang N, Jin H, Yu Z, Xu G, Huang Z . Clinical significance of astrocyte elevated gene-1 expression in human oligodendrogliomas. Clin Neurol Neurosurg 2010; 112: 413–419.
Article PubMed Google Scholar
- Zhu H, Wu H, Liu X, Li B, Chen Y, Ren X et al. Regulation of autophagy by a beclin 1-targeted microRNA, miR-30a, in cancer cells. Autophagy 2009; 5: 816–823.
Article CAS PubMed PubMed Central Google Scholar
- Zou Z, Wu L, Ding H, Wang Y, Zhang Y, Chen X et al. MicroRNA-30a sensitizes tumor cells to cis-platinum via suppressing beclin 1-mediated autophagy. J Biol Chem 2012; 287: 4148–4156.
Article CAS PubMed Google Scholar
- Lewis BP, Burge CB, Bartel DP . Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 2005; 120: 15–20.
Article CAS PubMed Google Scholar
- Krek A, Grun D, Poy MN, Wolf R, Rosenberg L, Epstein EJ et al. Combinatorial microRNA target predictions. Nat Genet 2005; 37: 495–500.
Article CAS PubMed Google Scholar
- John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS . Human MicroRNA targets. PLoS Biol 2004; 2: e363.
Article PubMed PubMed Central Google Scholar
- Lagana A, Forte S, Giudice A, Arena MR, Puglisi PL, Giugno R et al. miRo: a miRNA knowledge base. Database 2009; 2009: bap008.
Article CAS PubMed PubMed Central Google Scholar
- Hu G, Chong RA, Yang Q, Wei Y, Blanco MA, Li F et al. MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer. Cancer Cell 2009; 15: 9–20.
Article CAS PubMed PubMed Central Google Scholar
- Almeida MI, Reis RM, Calin GA . MicroRNA history: discovery, recent applications, and next frontiers. Mutat Res 2011; 717: 1–8.
Article CAS PubMed Google Scholar
- Bandres E, Cubedo E, Agirre X, Malumbres R, Zarate R, Ramirez N et al. Identification by real-time PCR of 13 mature microRNAs differentially expressed in colorectal cancer and non-tumoral tissues. Mol Cancer 2006; 5: 29.
Article CAS PubMed PubMed Central Google Scholar
- Porkka KP, Pfeiffer MJ, Waltering KK, Vessella RL, Tammela TL, Visakorpi T . MicroRNA expression profiling in prostate cancer. Cancer Res 2007; 67: 6130–6135.
Article CAS PubMed Google Scholar
- Yanaihara N, Caplen N, Bowman E, Seike M, Kumamoto K, Yi M et al. Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell 2006; 9: 189–198.
Article CAS PubMed Google Scholar
- Budhu A, Jia HL, Forgues M, Liu CG, Goldstein D, Lam A et al. Identification of metastasis-related microRNAs in hepatocellular carcinoma. Hepatology 2008; 47: 897–907.
Article CAS PubMed Google Scholar
- Cheng CW, Wang HW, Chang CW, Chu HW, Chen CY, Yu JC et al. MicroRNA-30a inhibits cell migration and invasion by downregulating vimentin expression and is a potential prognostic marker in breast cancer. Breast Cancer Res Treat 2012; 134: 1081–1093.
Article CAS PubMed Google Scholar
- Yang S, Li Y, Gao J, Zhang T, Li S, Luo A et al. MicroRNA-34 suppresses breast cancer invasion and metastasis by directly targeting Fra-1. Oncogene (e-pub ahead of print 24 September 2012; doi: 10.1038/onc.2012.432).
Article PubMed Google Scholar
- Chappell SA, Walsh T, Walker RA, Shaw JA . Loss of heterozygosity at chromosome 6q in preinvasive and early invasive breast carcinomas. Br J Cancer 1997; 75: 1324–1329.
Article CAS PubMed PubMed Central Google Scholar
- Noviello C, Courjal F, Theillet C . Loss of heterozygosity on the long arm of chromosome 6 in breast cancer: possibly four regions of deletion. Clin Cancer Res 1996; 2: 1601–1606.
CAS PubMed Google Scholar
- Ouzounova M, Vuong T, Ancey PB, Ferrand M, Durand G, Le-Calvez Kelm F et al. MicroRNA miR-30 family regulates non-attachment growth of breast cancer cells. BMC Genomics 2013; 14: 139.
Article CAS PubMed PubMed Central Google Scholar
- Gaziel-Sovran A, Segura MF, Di Micco R, Collins MK, Hanniford D, Vega-Saenz de Miera E et al. miR-30b/30d regulation of GalNAc transferases enhances invasion and immunosuppression during metastasis. Cancer Cell 2011; 20: 104–118.
Article CAS PubMed PubMed Central Google Scholar
- Yu F, Deng H, Yao H, Liu Q, Su F, Song E . Mir-30 reduction maintains self-renewal and inhibits apoptosis in breast tumor-initiating cells. Oncogene 2010; 29: 4194–4204.
Article CAS PubMed Google Scholar
- Rodriguez-Gonzalez FG, Sieuwerts AM, Smid M, Look MP, Meijer-van Gelder ME, de Weerd V et al. MicroRNA-30c expression level is an independent predictor of clinical benefit of endocrine therapy in advanced estrogen receptor positive breast cancer. Breast Cancer Res Treat 2011; 127: 43–51.
Article CAS PubMed Google Scholar
- Li J, Zhang N, Song LB, Liao WT, Jiang LL, Gong LY et al. Astrocyte elevated gene-1 is a novel prognostic marker for breast cancer progression and overall patient survival. Clin Cancer Res 2008; 14: 3319–3326.
Article CAS PubMed Google Scholar
- Li C, Li R, Song H, Wang D, Feng T, Yu X et al. Significance of aeg-1 expression in correlation with vegf, microvessel density and clinicopathological characteristics in triple-negative breast cancer. J Surg Oncol 2010; 103: 184–192.
Article PubMed Google Scholar
- Kikuno N, Shiina H, Urakami S, Kawamoto K, Hirata H, Tanaka Y et al. Knockdown of astrocyte-elevated gene-1 inhibits prostate cancer progression through upregulation of FOXO3a activity. Oncogene 2007; 26: 7647–7655.
Article CAS PubMed Google Scholar
- Lee SG, Jeon HY, Su ZZ, Richards JE, Vozhilla N, Sarkar D et al. Astrocyte elevated gene-1 contributes to the pathogenesis of neuroblastoma. Oncogene 2009; 28: 2476–2484.
Article CAS PubMed Google Scholar
- Yoo BK, Emdad L, Su ZZ, Villanueva A, Chiang DY, Mukhopadhyay ND et al. Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression. J Clin Invest 2009; 119: 465–477.
Article CAS PubMed PubMed Central Google Scholar
- Hu G, Wei Y, Kang Y . The multifaceted role of MTDH/AEG-1 in cancer progression. Clin Cancer Res 2009; 15: 5615–5620.
Article CAS PubMed PubMed Central Google Scholar
- Ward A, Balwierz A, Zhang JD, Kublbeck M, Pawitan Y, Hielscher T et al. Re-expression of microRNA-375 reverses both tamoxifen resistance and accompanying EMT-like properties in breast cancer. Oncogene 2012; 32: 1173–1182.
Article PubMed Google Scholar
- Zhang N, Wang X, Huo Q, Li X, Wang H, Schneider P et al. The oncogene metadherin modulates the apoptotic pathway based on the tumor necrosis factor superfamily member TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) in breast cancer. J Biol Chem 2013; 288: 9396–9407.
Article CAS PubMed PubMed Central Google Scholar
- Kong X, Moran MS, Zhao Y, Yang Q . Inhibition of metadherin sensitizes breast cancer cells to AZD6244. Cancer Biol Ther 2012; 13: 43–49.
Article CAS PubMed Google Scholar
- Nohata N, Hanazawa T, Kikkawa N, Mutallip M, Sakurai D, Fujimura L et al. Tumor suppressive microRNA-375 regulates oncogene AEG-1/MTDH in head and neck squamous cell carcinoma (HNSCC). J Hum Genet 2011; 56: 595–601.
Article CAS PubMed Google Scholar
- Hui ABY, Bruce JP, Alajez NM, Shi W, Yue S, Perez-Ordonez B et al. Significance of dysregulated metadherin and MicroRNA-375 in head and neck cancer. Clin Cancer Res 2011; 17: 7539–7550.
Article CAS PubMed Google Scholar
- Ward A, Balwierz A, Zhang JD, Kublbeck M, Pawitan Y, Hielscher T et al. Re-expression of microRNA-375 reverses both tamoxifen resistance and accompanying EMT-like properties in breast cancer. Oncogene 2013; 32: 1173–1182.
Article CAS PubMed Google Scholar
- Filipowicz W, Bhattacharyya SN, Sonenberg N . Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet 2008; 9: 102–114.
Article CAS PubMed Google Scholar
- Kumarswamy R, Mudduluru G, Ceppi P, Muppala S, Kozlowski M, Niklinski J et al. MicroRNA-30a inhibits epithelial-to-mesenchymal transition by targeting Snai1 and is downregulated in non-small cell lung cancer. Int J Cancer 2012; 130: 2044–2053.
Article CAS PubMed Google Scholar
- Brown DM, Ruoslahti E . Metadherin, a cell surface protein in breast tumors that mediates lung metastasis. Cancer Cell 2004; 5: 365–374.
Article CAS PubMed Google Scholar
- Zhang N, Kong X, Yan S, Yuan C, Yang Q . Huaier aqueous extract inhibits proliferation of breast cancer cells by inducing apoptosis. Cancer Sci 2010; 101: 2375–2383.
Article CAS PubMed Google Scholar
- Heckman KL, Pease LR . Gene splicing and mutagenesis by PCR-driven overlap extension. Nat Protocols 2007; 2: 924–932.
Article CAS PubMed Google Scholar