A novel role for non-ubiquitinated FANCD2 in response to hydroxyurea-induced DNA damage (original) (raw)

• Kim H, D'Andrea AD . Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway. Genes Dev 2012; 26: 1393–1408.
  Article CAS PubMed PubMed Central Google Scholar
• Green AM, Kupfer GM . Fanconi anemia. Hematol Oncol Clin North Am 2009; 23: 193–214.
  Article PubMed PubMed Central Google Scholar
• Wang W . Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins. Nat Rev Genet 2007; 8: 735–748.
  Article CAS Google Scholar
• Bagby GC, Alter BP . Fanconi anemia. Semin Hematol 2006; 43: 147–156.
  Article CAS Google Scholar
• Garaycoechea JI, Patel KJ . Why does the bone marrow fail in Fanconi anemia? Blood 2013; 123: 26–34.
  Article PubMed Google Scholar
• Pickering A, Zhang J, Panneerselvam J, Fei P . Advances in the understanding of Fanconi anemia tumor suppressor pathway. Cancer Biol Ther 2013; 14: 1089–1091.
  Article PubMed PubMed Central Google Scholar
• Alpi AF, Patel KJ . Monoubiquitylation in the Fanconi anemia DNA damage response pathway. DNA Repair 2009; 8: 430–435.
  Article CAS PubMed Google Scholar
• Holloman WK . Unraveling the mechanism of BRCA2 in homologous recombination. Nat Struct Mol Biol 2011; 18: 748–754.
  Article CAS PubMed PubMed Central Google Scholar
• Howlett NG, Taniguchi T, Olson S, Cox B, Waisfisz Q, De Die-Smulders C et al. Biallelic inactivation of BRCA2 in Fanconi anemia. Science 2002; 297: 606–609.
  Article CAS Google Scholar
• Lehmann AR, Niimi A, Ogi T, Brown S, Sabbioneda S, Wing JF et al. Translesion synthesis: Y-family polymerases and the polymerase switch. DNA Repair 2007; 6: 891–899.
  Article CAS PubMed Google Scholar
• Chang DJ, Cimprich KA . DNA damage tolerance: when it's OK to make mistakes. Nat Chem Biol 2009; 5: 82–90.
  Article CAS PubMed PubMed Central Google Scholar
• Watanabe K, Tateishi S, Kawasuji M, Tsurimoto T, Inoue H, Yamaizumi M et al. Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination. EMBO J 2004; 23: 3886–3896.
  Article CAS PubMed PubMed Central Google Scholar
• Williams SA, Longerich S, Sung P, Vaziri C, Kupfer GM . The E3 ubiquitin ligase RAD18 regulates ubiquitylation and chromatin loading of FANCD2 and FANCI. Blood 2011; 117: 5078–5087.
  Article CAS PubMed PubMed Central Google Scholar
• Howlett NG, Harney JA, Rego MA, Kolling FWt, Glover TW . Functional interaction between the Fanconi Anemia D2 protein and proliferating cell nuclear antigen (PCNA) via a conserved putative PCNA interaction motif. J Biol Chem 2009; 284: 28935–28942.
  Article CAS PubMed PubMed Central Google Scholar
• Hussain S, Wilson JB, Medhurst AL, Hejna J, Witt E, Ananth S et al. Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways. Hum Mol Genet 2004; 13: 1241–1248.
  Article CAS PubMed Google Scholar
• Nijman SM, Huang TT, Dirac AM, Brummelkamp TR, Kerkhoven RM, D'Andrea AD et al. The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway. Mol Cell 2005; 17: 331–339.
  Article CAS PubMed Google Scholar
• Huang TT, Nijman SM, Mirchandani KD, Galardy PJ, Cohn MA, Haas W et al. Regulation of monoubiquitinated PCNA by DUB autocleavage. Nat Cell Biol 2006; 8: 339–347.
  CAS PubMed Google Scholar
• Palle K, Vaziri C . Rad18 E3 ubiquitin ligase activity mediates Fanconi anemia pathway activation and cell survival following DNA Topoisomerase 1 inhibition. Cell Cycle 2011; 10: 1625–1638.
  Article CAS PubMed PubMed Central Google Scholar
• Mirchandani KD, McCaffrey RM, D'Andrea AD . The Fanconi anemia core complex is required for efficient point mutagenesis and Rev1 foci assembly. DNA Repair 2008; 7: 902–911.
  Article CAS PubMed PubMed Central Google Scholar
• Knipscheer P, Raschle M, Smogorzewska A, Enoiu M, Ho TV, Scharer OD et al. The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair. Science 2009; 326: 1698–1701.
  Article CAS PubMed PubMed Central Google Scholar
• Fu D, Dudimah FD, Zhang J, Pickering A, Paneerselvam J, Palrasu M et al. Recruitment of DNA polymerase eta by FANCD2 in the early response to DNA damage. Cell Cycle 2013; 12: 803–809.
  Article CAS PubMed PubMed Central Google Scholar
• Howlett NG, Taniguchi T, Durkin SG, D'Andrea AD, Glover TW . The Fanconi anemia pathway is required for the DNA replication stress response and for the regulation of common fragile site stability. Hum Mol Genet 2005; 14: 693–701.
  Article CAS PubMed Google Scholar
• McCabe KM, Hemphill A, Akkari Y, Jakobs PM, Pauw D, Olson SB et al. ERCC1 is required for FANCD2 focus formation. Mol Genet Metab 2008; 95: 66–73.
  Article CAS PubMed PubMed Central Google Scholar
• Dunn J, Potter M, Rees A, Runger TM . Activation of the Fanconi anemia/BRCA pathway and recombination repair in the cellular response to solar ultraviolet light. Cancer Res 2006; 66: 11140–11147.
  Article CAS PubMed Google Scholar
• Tanaka T, Huang X, Halicka HD, Zhao H, Traganos F, Albino AP et al. Cytometry of ATM activation and histone H2AX phosphorylation to estimate extent of DNA damage induced by exogenous agents. Cytometry A 2007; 71: 648–661.
  Article PubMed Google Scholar
• Koc A, Wheeler LJ, Mathews CK, Merrill GF . Hydroxyurea arrests DNA replication by a mechanism that preserves basal dNTP pools. J Biol Chem 2004; 279: 223–230.
  Article CAS PubMed Google Scholar
• Schlacher K, Wu H, Jasin M . A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2. Cancer Cell 2012; 22: 106–116.
  Article CAS PubMed PubMed Central Google Scholar
• Chaudhury I, Sareen A, Raghunandan M, Sobeck A . FANCD2 regulates BLM complex functions independently of FANCI to promote replication fork recovery. Nucleic Acids Res 2013; 41: 6444–6459.
  Article CAS PubMed PubMed Central Google Scholar
• Lossaint G, Larroque M, Ribeyre C, Bec N, Larroque C, Decaillet C et al. FANCD2 binds MCM proteins and controls replisome function upon activation of S phase checkpoint signaling. Mol Cell 2013; 51: 678–690.
  Article CAS PubMed Google Scholar
• Suhasini AN, Rawtani NA, Wu Y, Sommers JA, Sharma S, Mosedale G et al. Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome. EMBO J 2011; 30: 692–705.
  Article CAS PubMed PubMed Central Google Scholar
• Johnstone P, Reifsteck C, Kohler S, Worland P, Olson S, Moses RE et al. Fanconi anemia group A and D cell lines respond normally to inhibitors of cell cycle regulation. Somat Cell Mol Genet 1997; 23: 371–377.
  Article CAS PubMed Google Scholar
• Maurer-Schultze B, Siebert M, Bassukas ID . An in vivo study on the synchronizing effect of hydroxyurea. Exp Cell Res 1988; 174: 230–243.
  Article CAS PubMed Google Scholar
• Miyase S, Tateishi S, Watanabe K, Tomita K, Suzuki K, Inoue H et al. Differential regulation of Rad18 through Rad6-dependent mono- and polyubiquitination. J Biol Chem 2005; 280: 515–524.
  Article CAS PubMed Google Scholar
• Zeman MK, Lin JR, Freire R, Cimprich KA . DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis. J Cell Biol 2014; 206: 183–197.
  Article CAS PubMed PubMed Central Google Scholar
• Brown S, Niimi A, Lehmann AR . Ubiquitination and deubiquitination of PCNA in response to stalling of the replication fork. Cell Cycle 2009; 8: 689–692.
  Article CAS PubMed Google Scholar
• Chen J, Bozza W, Zhuang Z . Ubiquitination of PCNA and its essential role in eukaryotic translesion synthesis. Cell Biochem Biophys 2011; 60: 47–60.
  Article PubMed Google Scholar
• Terai K, Abbas T, Jazaeri AA, Dutta A . CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis. Mol Cell 2010; 37: 143–149.
  Article CAS PubMed PubMed Central Google Scholar
• Bindra RS, Goglia AG, Jasin M, Powell SN . Development of an assay to measure mutagenic non-homologous end-joining repair activity in mammalian cells. Nucleic Acids Res 2013; 41: e115.
  Article CAS PubMed PubMed Central Google Scholar
• Hoege C, Pfander B, Moldovan GL, Pyrowolakis G, Jentsch S . RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature 2002; 419: 135–141.
  Article CAS PubMed Google Scholar
• Stelter P, Ulrich HD . Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation. Nature 2003; 425: 188–191.
  Article CAS Google Scholar
• Kannouche PL, Lehmann AR . Ubiquitination of PCNA and the polymerase switch in human cells. Cell Cycle 2004; 3: 1011–1013.
  Article CAS PubMed Google Scholar
• Moldovan GL, Dejsuphong D, Petalcorin MI, Hofmann K, Takeda S, Boulton SJ et al. Inhibition of homologous recombination by the PCNA-interacting protein PARI. Mol Cell 2012; 45: 75–86.
  Article CAS PubMed Google Scholar
• Lin JR, Zeman MK, Chen JY, Yee MC, Cimprich KA . SHPRH and HLTF act in a damage-specific manner to coordinate different forms of postreplication repair and prevent mutagenesis. Mol Cell 2011; 42: 237–249.
  Article CAS PubMed PubMed Central Google Scholar
• Williams SA, Wilson JB, Clark AP, Mitson-Salazar A, Tomashevski A, Ananth S et al. Functional and physical interaction between the mismatch repair and FA-BRCA pathways. Hum Mol Genet 2011; 20: 4395–4410.
  Article CAS PubMed PubMed Central Google Scholar
• Hirano S, Yamamoto K, Ishiai M, Yamazoe M, Seki M, Matsushita N et al. Functional relationships of FANCC to homologous recombination, translesion synthesis, and BLM. EMBO J 2005; 24: 418–427.
  Article CAS PubMed Google Scholar
• Reliene R, Yamamoto ML, Rao PN, Schiestl RH . Genomic instability in mice is greater in Fanconi anemia caused by deficiency of Fancd2 than Fancg. Cancer Res 2010; 70: 9703–9710.
  Article CAS PubMed PubMed Central Google Scholar
• Ho TV, Scharer OD, Translesion DNA . synthesis polymerases in DNA interstrand crosslink repair. Environ Mol Mutagen 2010; 51: 552–566.
  CAS PubMed Google Scholar
• Nakanishi K, Yang YG, Pierce AJ, Taniguchi T, Digweed M, D'Andrea AD et al. Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair. Proc Natl Acad Sci USA 2005; 102: 1110–1115.
  Article CAS PubMed Google Scholar
• Petermann E, Orta ML, Issaeva N, Schultz N, Helleday T . Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair. Mol Cell 2010; 37: 492–502.
  Article CAS PubMed PubMed Central Google Scholar
• Qiao F, Moss A, Kupfer GM . Fanconi anemia proteins localize to chromatin and the nuclear matrix in a DNA damage- and cell cycle-regulated manner. J Biol Chem 2001; 276: 23391–23396.
  Article CAS PubMed Google Scholar