The role of Th17 and Treg responses in the pathogenesis of RSV infection (original) (raw)
Bueno SM, González PA, Pacheco R, et al. Host immunity during RSV pathogenesis. Int Immunopharmacol 2008;8:1320–9. ArticleCASPubMed Google Scholar
McNamara PS, Smyth RL. The pathogenesis of respiratory syncytial virus disease in childhood. Br Med Bull 2002;61:13–28. ArticleCASPubMed Google Scholar
Hervás D, Reina J, Yañez A, del Valle JM, Figuerola J, Hervás JA. Epidemiology of hospitalization for acute bronchiolitis in children: differences between RSV and non-RSV bronchiolitis. Eur J Clin Microbiol Infect Dis 2012;31:1975–81. ArticlePubMed Google Scholar
Oshansky CM, Zhang W, Moore E, Tripp RA. The host response and molecular pathogenesis associated with respiratory syncytial virus infection. Future Microbiol 2009;4:279–97. ArticleCASPubMed Google Scholar
Welliver RC. Respiratory syncytial virus and other respiratory viruses. Pediatr Infect Dis J 2003;22(2 Suppl):S6–10; discussion S10–2. PubMed Google Scholar
Bueno SM, González PA, Riedel CA, Carreño LJ, Vásquez AE, Kalergis AM. Local cytokine response upon respiratory syncytial virus infection. Immunol Lett 2011;136:122–9. ArticleCASPubMed Google Scholar
González PA, Bueno SM, Carreño LJ, Riedel CA, Kalergis AM. Respiratory syncytial virus infection and immunity. Rev Med Virol 2012;22:230–44. ArticleCASPubMed Google Scholar
Becker Y. Respiratory syncytial virus (RSV) evades the human adaptive immune system by skewing the Th1/Th2 cytokine balance toward increased levels of Th2 cytokines and IgE, markers of allergy–a review. Virus Genes 2006;33:235–52. ArticleCASPubMed Google Scholar
Heylen M, Ruyssers NE, Gielis EM, et al. Of worms, mice and man: an overview of experimental and clinical helminth-based therapy for inflammatory bowel disease. Pharmacol Ther 2014;143:153–67. ArticleCASPubMed Google Scholar
Loebbermann J, Durant L, Thornton H, Johansson C, Openshaw PJ. Defective immunoregulation in RSV vaccine-augmented viral lung disease restored by selective chemoattraction of regulatory T cells. Proc Natl Acad Sci USA 2013;110:2987–92. ArticleCASPubMedPubMed Central Google Scholar
Hassan MA, Eldin AM, Ahmed MM. T - helper2 /T - helper1 imbalance in respiratory syncytial virus bronchiolitis in relation to disease severity and outcome. Egypt J Immunol 2008;15:153–60. PubMed Google Scholar
Raveh D, Kruskal BA, Farland J, Ezekowitz RA. Th1 and Th2 cytokines cooperate to stimulate mannose-receptor-mediated phagocytosis. J Leukoc Biol 1998;64:108–13. ArticleCASPubMed Google Scholar
Bembridge GP, Garcia-Beato R, López JA, Melero JA, Taylor G. Subcellular site of expression and route of vaccination influence pulmonary eosinophilia following respiratory syncytial virus challenge in BALB/c mice sensitized to the attachment G protein. J Immunol 1998;161:2473–80. CASPubMed Google Scholar
Johnson TR, Graham BS. Secreted respiratory syncytial virus G glycoprotein induces interleukin-5 (IL-5), IL-13, and eosinophilia by an IL-4-independent mechanism. J Virol 1999;73:8485–95. CASPubMedPubMed Central Google Scholar
Qin L, Peng D, Hu C, et al. Differentiation of Th subsets inhibited by nonstructural proteins of respiratory syncytial virus is mediated by ubiquitination. PLoS One 2014;9:e101469. ArticleCASPubMedPubMed Central Google Scholar
Dulek DE, Newcomb DC, Toki S, et al. STAT4 deficiency fails to induce lung Th2 or Th17 immunity following primary or secondary respiratory syncytial virus (RSV) challenge but enhances the lung RSV-specific CD8+ T cell immune response to secondary challenge. J Virol 2014;88:9655–72. ArticleCASPubMedPubMed Central Google Scholar
Bendelja K, Gagro A, Bace A, et al. Predominant type-2 response in infants with respiratory syncytial virus (RSV) infection demonstrated by cytokine flow cytometry. Clin Exp Immunol 2000;121:332–8. ArticleCASPubMedPubMed Central Google Scholar
Legg JP, Hussain IR, Warner JA, Johnston SL, Warner JO. Type 1 and type 2 cytokine imbalance in acute respiratory syncytial virus bronchiolitis. Am J Respir Crit Care Med 2003;168:633–9. ArticlePubMed Google Scholar
Román M, Calhoun WJ, Hinton KL, et al. Respiratory syncytial virus infection in infants is associated with predominant Th-2-like response. Am J Respir Crit Care Med 1997;156:190–5. ArticlePubMed Google Scholar
Bont L, Heijnen CJ, Kavelaars A, et al. Peripheral blood cytokine responses and disease severity in respiratory syncytial virus bronchiolitis. Eur Respir J 1999;14:144–9. ArticleCASPubMed Google Scholar
Brandenburg AH, Kleinjan A, van Het Land B, et al. Type 1-like immune response is found in children with respiratory syncytial virus infection regardless of clinical severity. J Med Virol 2000;62:267–77. ArticleCASPubMed Google Scholar
Garofalo RP, Patti J, Hintz KA, Hill V, Ogra PL, Welliver RC. Macrophage inflammatory protein-1alpha (not T helper type 2 cytokines) is associated with severe forms of respiratory syncytial virus bronchiolitis. J Infect Dis 2001;184:393–9. ArticleCASPubMed Google Scholar
Pinto RA, Arredondo SM, Bono MR, Gaggero AA, Díaz PV. T helper 1/T helper 2 cytokine imbalance in respiratory syncytial virus infection is associated with increased endogenous plasma cortisol. Pediatrics 2006;117:e878–86. ArticlePubMed Google Scholar
van Benten IJ, van Drunen CM, Koopman LP, et al. RSV-induced bronchiolitis but not upper respiratory tract infection is accompanied by an increased nasal IL-18 response. J Med Virol 2003;71:290–7. ArticleCASPubMedPubMed Central Google Scholar
Eisenstein EM, Williams CB. The T(reg)/Th17 cell balance: a new paradigm for autoimmunity. Pediatr Res 2009;65(5 Pt 2):26R–31R. ArticleCASPubMed Google Scholar
Afzali B, Mitchell P, Lechler RI, John S, Lombardi G. Translational mini-review series on Th17 cells: induction of interleukin-17 production by regulatory T cells. Clin Exp Immunol 2010;159:120–30. ArticleCASPubMedPubMed Central Google Scholar
O’Connor RA, Taams LS, Anderton SM. Translational mini-review series on Th17 cells: CD4 T helper cells: functional plasticity and differential sensitivity to regulatory T cell-mediated regulation. Clin Exp Immunol 2010;159:137–47. ArticleCASPubMedPubMed Central Google Scholar
Fantini MC, Becker C, Monteleone G, Pallone F, Galle PR, Neurath MF. Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7. J Immunol 2004;172:5149–53. ArticleCASPubMed Google Scholar
Miyara M, Sakaguchi S. Natural regulatory T cells: mechanisms of suppression. Trends Mol Med 2007;13:108–16. ArticleCASPubMed Google Scholar
Bopp T, Becker C, Klein M, et al. Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression. J Exp Med 2007;204:1303–10. ArticleCASPubMedPubMed Central Google Scholar
Huang CT, Workman CJ, Flies D, et al. Role of LAG-3 in regulatory T cells. Immunity 2004;21:503–13. ArticleCASPubMed Google Scholar
Fulton RB, Meyerholz DK, Varga SM. Foxp3+ CD4 regulatory T cells limit pulmonary immunopathology by modulating the CD8 T cell response during respiratory syncytial virus infection. J Immunol 2010;185:2382–92. ArticleCASPubMed Google Scholar
Raiden S, Pandolfi J, Payasliàn F, et al. Depletion of circulating regulatory T cells during severe respiratory syncytial virus infection in young children. Am J Respir Crit Care Med 2014;189:865–8. ArticleCASPubMed Google Scholar
Lee DC, Harker JA, Tregoning JS, et al. CD25+ natural regulatory T cells are critical in limiting innate and adaptive immunity and resolving disease following respiratory syncytial virus infection. J Virol 2010;84:8790–8. ArticleCASPubMedPubMed Central Google Scholar
Ruckwardt TJ, Bonaparte KL, Nason MC, Graham BS. Regulatory T cells promote early influx of CD8+ T cells in the lungs of respiratory syncytial virus-infected mice and diminish immunodominance disparities. J Virol 2009;83:3019–28. ArticleCASPubMedPubMed Central Google Scholar
Loebbermann J, Thornton H, Durant L, et al. Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection. Mucosal Immunol 2012;5:161–72. ArticleCASPubMedPubMed Central Google Scholar
Durant LR, Makris S, Voorburg CM, Loebbermann J, Johansson C, Openshaw PJ. Regulatory T cells prevent Th2 immune responses and pulmonary eosinophilia during respiratory syncytial virus infection in mice. J Virol 2013;87:10946–54. ArticleCASPubMedPubMed Central Google Scholar
Loebbermann J, Schnoeller C, Thornton H, et al. IL-10 regulates viral lung immunopathology during acute respiratory syncytial virus infection in mice. PLoS One 2012;7:e32371. ArticleCASPubMedPubMed Central Google Scholar
Weiss KA, Christiaansen AF, Fulton RB, Meyerholz DK, Varga SM. Multiple CD4+ T cell subsets produce immunomodulatory IL-10 during respiratory syncytial virus infection. J Immunol 2011;187:3145–54. ArticleCASPubMed Google Scholar
Liu J, Cao S, Peppers G, Kim SH, Graham BS. Clonotype-specific avidity influences the dynamics and hierarchy of virus-specific regulatory and effector CD4(+) T-cell responses. Eur J Immunol 2014;44:1058–68. ArticleCASPubMed Google Scholar
Wang J, Kong L, Luo Q, et al. Dual effects of respiratory syncytial virus infections on airway inflammation by regulation of Th17/Treg responses in ovalbumin-challenged mice. Inflammation 2014;37:1984–2005. ArticleCASPubMed Google Scholar
Habibi MS, Openshaw PJ. Benefit and harm from immunity to respiratory syncytial virus: implications for treatment. Curr Opin Infect Dis 2012;25:687–94. ArticleCASPubMed Google Scholar
de Jong E, Suddason T, Lord GM. Translational mini-review series on Th17 cells: development of mouse and human T helper 17 cells. Clin Exp Immunol 2010;159:148–58. ArticleCASPubMedPubMed Central Google Scholar
Crome SQ, Wang AY, Levings MK. Translational mini-review series on Th17 cells: function and regulation of human T helper 17 cells in health and disease. Clin Exp Immunol 2010;159:109–19. ArticleCASPubMedPubMed Central Google Scholar
Bera MM, Lu B, Martin TR, et al. Th17 cytokines are critical for respiratory syncytial virus-associated airway hyperreponsiveness through regulation by complement C3a and tachykinins. J Immunol 2011;187:4245–55. ArticleCASPubMed Google Scholar
Mukherjee S, Lindell DM, Berlin AA, et al. IL-17-induced pulmonary pathogenesis during respiratory viral infection and exacerbation of allergic disease. Am J Pathol 2011;179:248–58. ArticleCASPubMedPubMed Central Google Scholar
de Almeida Nagata DE, Demoor T, Ptaschinski C, et al. IL-27R-mediated regulation of IL-17 controls the development of respiratory syncytial virus-associated pathogenesis. Am J Pathol 2014;184:1807–18. ArticleCASPubMedPubMed Central Google Scholar
Larrañaga CL, Ampuero SL, Luchsinger VF, et al. Impaired immune response in severe human lower tract respiratory infection by respiratory syncytial virus. Pediatr Infect Dis J 2009;28:867–73. ArticlePubMed Google Scholar
Stoppelenburg AJ, de Roock S, Hennus MP, Bont L, Boes M. Elevated Th17 response in infants undergoing respiratory viral infection. Am J Pathol 2014;184:1274–9. ArticleCASPubMed Google Scholar
Faber TE, Groen H, Welfing M, Jansen KJ, Bont LJ. Specific increase in local IL-17 production during recovery from primary RSV bronchiolitis. J Med Virol 2012;84:1084–8. ArticleCASPubMed Google Scholar
Bystrom J, Al-Adhoubi N, Al-Bogami M, Jawad AS, Mageed RA. Th17 lymphocytes in respiratory syncytial virus infection. Viruses 2013;5:777–91. ArticleCASPubMedPubMed Central Google Scholar
Hashimoto K, Durbin JE, Zhou W, et al. Respiratory syncytial virus infection in the absence of STAT 1 results in airway dysfunction, airway mucus, and augmented IL-17 levels. J Allergy Clin Immunol 2005;116:550–7. ArticleCASPubMed Google Scholar
O’Garra A, Arai N. The molecular basis of T helper 1 and T helper 2 cell differentiation. Trends Cell Biol 2000;10:542–50. ArticlePubMed Google Scholar
Gorelik L, Constant S, Flavell RA. Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation. J Exp Med 2002;195:1499–505. ArticleCASPubMedPubMed Central Google Scholar
Noben-Trauth N, Hu-Li J, Paul WE. Conventional, naive CD4+ T cells provide an initial source of IL-4 during Th2 differentiation. J Immunol 2000;165:3620–5. ArticleCASPubMed Google Scholar
Heath VL, Murphy EE, Crain C, Tomlinson MG, O’Garra A. TGF-beta1 down-regulates Th2 development and results in decreased IL-4-induced STAT6 activation and GATA-3 expression. Eur J Immunol 2000;30:2639–49. ArticleCASPubMed Google Scholar
Bi Y, Yang R. Direct and indirect regulatory mechanisms in TH17 cell differentiation and functions. Scand J Immunol 2012;75:543–52. ArticleCASPubMed Google Scholar
Tran DQ. TGF-β: the sword, the wand, and the shield of FOXP3(+) regulatory T cells. J Mol Cell Biol 2012;4:29–37. ArticleCASPubMed Google Scholar
Zhou L, Chong MM, Littman DR. Plasticity of CD4+ T cell lineage differentiation. Immunity 2009;30:646–55. ArticleCASPubMed Google Scholar
Di Cesare A, Di Meglio P, Nestle FO. The IL-23/Th17 axis in the immunopathogenesis of psoriasis. J Invest Dermatol 2009;129:1339–50. ArticleCASPubMed Google Scholar
Gutcher I, Donkor MK, Ma Q, Rudensky AY, Flavell RA, Li MO. Autocrine transforming growth factor-β1 promotes in vivo Th17 cell differentiation. Immunity 2011;34:396–408. ArticleCASPubMedPubMed Central Google Scholar
Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 2006;24:179–89. ArticleCASPubMed Google Scholar
McGeachy MJ, Chen Y, Tato CM, et al. The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo. Nat Immunol 2009;10:314–24. ArticleCASPubMedPubMed Central Google Scholar
Wojno ED, Hunter CA. New directions in the basic and translational biology of interleukin-27. Trends Immunol 2012;33:91–7. ArticleCASPubMed Google Scholar
Yeh WI, McWilliams IL, Harrington LE. IFNγ inhibits Th17 differentiation and function via Tbet-dependent and Tbet-independent mechanisms. J Neuroimmunol 2014;267:20–7. ArticleCASPubMed Google Scholar
Laurence A, Tato CM, Davidson TS, et al. Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity 2007;26:371–81. ArticleCASPubMed Google Scholar
Villarino AV, Gallo E, Abbas AK. STAT1-activating cytokines limit Th17 responses through both T-bet-dependent and -independent mechanisms. J Immunol 2010;185:6461–71. ArticleCASPubMed Google Scholar
Newcomb DC, Boswell MG, Huckabee MM, et al. IL-13 regulates Th17 secretion of IL-17A in an IL-10-dependent manner. J Immunol 2012;188:1027–35. ArticleCASPubMed Google Scholar
Zhou L, Lopes JE, Chong MM, et al. TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature 2008;453:236–40. ArticleCASPubMedPubMed Central Google Scholar
Hemdan NY, Birkenmeier G, Wichmann G. Key molecules in the differentiation and commitment program of T helper 17 (Th17) cells up-to-date. Immunol Lett 2012;148:97–109. ArticleCASPubMed Google Scholar
Yang L, Anderson DE, Baecher-Allan C, et al. IL-21 and TGF-beta are required for differentiation of human T(H)17 cells. Nature 2008;454:350–2. ArticleCASPubMedPubMed Central Google Scholar
Boniface K, Blom B, Liu YJ, de Waal Malefyt R. From interleukin-23 to T-helper 17 cells: human T-helper cell differentiation revisited. Immunol Rev 2008;226:132–46. ArticleCASPubMedPubMed Central Google Scholar
González PA, Prado CE, Leiva ED, et al. Respiratory syncytial virus impairs T cell activation by preventing synapse assembly with dendritic cells. Proc Natl Acad Sci USA 2008;105:14999–5004. ArticlePubMedPubMed Central Google Scholar
Lotz MT, Peebles RS Jr . Mechanisms of respiratory syncytial virus modulation of airway immune responses. Curr Allergy Asthma Rep 2012;12:380–7. ArticleCASPubMedPubMed Central Google Scholar
Feng J, Hu Y, Song Z, Liu Y, Guo X, Jie Z. Interleukin-23 facilitates Th1 and Th2 cell differentiation in vitro following respiratory syncytial virus infection. J Med Virol 2015;87:708–15. ArticleCASPubMed Google Scholar
Qin L, Hu CP, Feng JT, Xia Q. Activation of lymphocytes induced by bronchial epithelial cells with prolonged RSV infection. PLoS One 2011;6:e27113. ArticleCASPubMedPubMed Central Google Scholar
Krishnamoorthy N, Khare A, Oriss TB, et al. Early infection with respiratory syncytial virus impairs regulatory T cell function and increases susceptibility to allergic asthma. Nat Med 2012;18:1525–30. ArticleCASPubMedPubMed Central Google Scholar
Reed M, Morris SH, Owczarczyk AB, Lukacs NW. Deficiency of autophagy protein Map1-LC3b mediates IL-17-dependent lung pathology during respiratory viral infection via ER stress-associated IL-1. Mucosal Immunol 2015;8:1118–30. ArticleCASPubMedPubMed Central Google Scholar
de Almeida Nagata DE, Ting HA, Cavassani KA, et al. Epigenetic control of Foxp3 by SMYD3 H3K4 histone methyltransferase controls iTreg development and regulates pathogenic T-cell responses during pulmonary viral infection. Mucosal Immunol 2015;8:1131–43. ArticleCASPubMed Central Google Scholar
Koenen HJ, Smeets RL, Vink PM, van Rijssen E, Boots AM, Joosten I. Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells. Blood 2008;112:2340–52. ArticleCASPubMed Google Scholar
Gautreau L, Chabannes D, Heslan M, Josien R. Modulation of regulatory T cell-Th17 balance by plasmacytoid dendritic cells. J Leukoc Biol 2011;90:521–7. ArticleCASPubMed Google Scholar
Zeng R, Zhang H, Hai Y, et al. Interleukin-27 inhibits vaccine-enhanced pulmonary disease following respiratory syncytial virus infection by regulating cellular memory responses. J Virol 2012;86:4505–17. ArticleCASPubMedPubMed Central Google Scholar
Li B, Wu FL, Feng XB, Sun DK, Cui QQ, Zhao ZX. [Changes and the clinical significance of CD4+ CD25+ regulatory T cells and Th17 cells in peripheral blood of infants with respiratory syncytial virus bronchiolitis]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2012;28:426–8. PubMed Google Scholar
Lu X, McCoy KS, Xu J, et al. Galectin-9 ameliorates respiratory syncytial virus-induced pulmonary immunopathology through regulating the balance between Th17 and regulatory T cells. Virus Res 2015;195:162–71. ArticleCASPubMed Google Scholar
Anderson LJ. Respiratory syncytial virus vaccine development. Semin Immunol 2013;25:160–71. ArticlePubMed Google Scholar
Espinoza JA, Bueno SM, Riedel CA, Kalergis AM. Induction of protective effector immunity to prevent pathogenesis caused by the respiratory syncytial virus. Implications on therapy and vaccine design. Immunology 2014;143:1–12. ArticleCASPubMedPubMed Central Google Scholar
Turner TL, Kopp BT, Paul G, Landgrave LC, Hayes D Jr, Thompson R. Respiratory syncytial virus: current and emerging treatment options. Clinicoecon Outcomes Res 2014;6:217–25. ArticlePubMedPubMed Central Google Scholar