- Green, D. R. & Levine, B. To be or not to be? How selective autophagy and cell death govern cell fate. Cell 157, 65–75 (2014).
Article PubMed PubMed Central CAS Google Scholar
- Galluzzi, L. et al. Molecular definitions of autophagy and related processes. EMBO J. 36, 1811–1836 (2017).
Article PubMed CAS PubMed Central Google Scholar
- Stolz, A., Ernst, A. & Dikic, I. Cargo recognition and trafficking in selective autophagy. Nat. Cell Biol. 16, 495–501 (2014).
Article PubMed CAS Google Scholar
- De Duve, C. & Wattiaux, R. Functions of lysosomes. Annu. Rev. Physiol. 28, 435–492 (1966).
Article PubMed Google Scholar
- Marzella, L., Ahlberg, J. & Glaumann, H. Autophagy, heterophagy, microautophagy and crinophagy as the means for intracellular degradation. Virchows Archiv B Cell Pathol. Incl. Mol. Pathol. 36, 219–234 (1981).
Article CAS Google Scholar
- Roberts, P. et al. Piecemeal microautophagy of nucleus in Saccharomyces cerevisiae. Mol. Biol. Cell 14, 129–141 (2003).
Article PubMed CAS Google Scholar
- Sakai, Y., Koller, A., Rangell, L., Keller, G. & Subramani, S. Peroxisome degradation by microautophagy in Pichia pastoris. Identification of specific steps and morphological intermediates. J. Cell Biol. 141, 625–636 (1998).
Article PubMed PubMed Central CAS Google Scholar
- Sahu, R. et al. Microautophagy of cytosolic proteins by late endosomes. Dev. Cell 20, 131–139 (2011). First report of endosomal microautophagy.
Article PubMed PubMed Central CAS Google Scholar
- Dice, J. F. Peptide sequences that target cytosolic proteins for lysosomal proteolysis. Trends Biochem. Sci. 15, 305–309 (1990). First characterization of the properties of the KFERQ-like signal.
Article PubMed CAS Google Scholar
- Terlecky, S. R., Chiang, H.-L., Olson, T. S. & Dice, J. F. Protein and peptide binding and stimulation of in vitro lysosomal proteolysis by the 73-kDa heat shock cognate protein. J. Biol. Chem. 267, 9202–9209 (1992).
PubMed CAS Google Scholar
- Cuervo, A. M., Terlecky, S. R., Dice, J. F. & Knecht, E. Selective binding and uptake of ribonuclease A and glyceraldehyde-3-phosphate dehydrogenase by isolated rat liver lysosomes. J. Biol. Chem. 269, 26374–26380 (1994).
PubMed CAS Google Scholar
- Eskelinen, E. L. et al. Unifying nomenclature for the isoforms of the lysosomal membrane protein LAMP-2. Traffic 6, 1058–1061 (2005).
Article PubMed CAS Google Scholar
- Massey, A. C., Kaushik, S., Sovak, G., Kiffin, R. & Cuervo, A. M. Consequences of the selective blockage of chaperone-mediated autophagy. Proc. Natl Acad. Sci. USA 103, 5805–5810 (2006).
Article PubMed PubMed Central CAS Google Scholar
- Bandyopadhyay, U., Sridhar, S., Kaushik, S., Kiffin, R. & Cuervo, A. M. Identification of regulators of chaperone-mediated autophagy. Mol. Cell 39, 535–547 (2010).
Article PubMed PubMed Central CAS Google Scholar
- Bandyopadhyay, U., Kaushik, S., Varticovski, L. & Cuervo, A. M. The chaperone-mediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membrane. Mol. Cell. Biol. 28, 5747–5763 (2008). Identification of the CMA translocation complex at the lysosomal membrane.
Article PubMed PubMed Central Google Scholar
- Arias, E. et al. Lysosomal mTORC2/PHLPP1/Akt regulate chaperone-mediated autophagy. Mol. Cell 59, 270–284 (2015).
Article PubMed PubMed Central CAS Google Scholar
- Cuervo, A. M., Stefanis, L., Fredenburg, R., Lansbury, P. T. & Sulzer, D. Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science 305, 1292–1295 (2004). First connection of CMA malfunction with a human disorder (neurodegeneration).
Article PubMed CAS Google Scholar
- Kon, M. et al. Chaperone-mediated autophagy is required for tumor growth. Sci. Transl Med. 3, 109ra117 (2011).
Article PubMed PubMed Central CAS Google Scholar
- Schneider, J. L., Suh, Y. & Cuervo, A. M. Deficient chaperone-mediated autophagy in liver leads to metabolic dysregulation. Cell Metab. 20, 417–432 (2014). First mouse model with tissue-specific CMA blockage in vivo.
Article PubMed PubMed Central CAS Google Scholar
- Schneider, J. L. et al. Loss of hepatic chaperone-mediated autophagy accelerates proteostasis failure in aging. Aging Cell 14, 249–264 (2015).
Article PubMed PubMed Central CAS Google Scholar
- Valdor, R. et al. Chaperone-mediated autophagy regulates T cell responses through targeted degradation of negative regulators of T cell activation. Nat. Immunol. 15, 1046–1054 (2014).
Article PubMed PubMed Central CAS Google Scholar
- Dice, J. F. Altered degradation of proteins microinjected into senescent human fibroblasts. J. Biol. Chem. 257, 14624–14627 (1982).
PubMed CAS Google Scholar
- Kaushik, S. & Cuervo, A. M. AMPK-dependent phosphorylation of lipid droplet protein PLIN2 triggers its degradation by CMA. Autophagy 12, 432–438 (2016).
Article PubMed PubMed Central CAS Google Scholar
- Park, C., Suh, Y. & Cuervo, A. M. Regulated degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage. Nat. Commun. 6, 6823 (2015).
Article PubMed PubMed Central CAS Google Scholar
- Quintavalle, C. et al. Phosphorylation-regulated degradation of the tumor-suppressor form of PED by chaperone-mediated autophagy in lung cancer cells. J. Cell. Physiol. 229, 1359–1368 (2014).
Article PubMed PubMed Central CAS Google Scholar
- Zhou, J. et al. Chaperone-mediated autophagy regulates proliferation by targeting RND3 in gastric cancer. Autophagy 12, 515–528 (2016).
Article PubMed PubMed Central CAS Google Scholar
- Lv, L. et al. Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth. Mol. Cell 42, 719–730 (2011).
Article PubMed PubMed Central CAS Google Scholar
- Bonhoure, A. et al. Acetylation of translationally controlled tumor protein promotes its degradation through chaperone-mediated autophagy. Eur. J. Cell Biol. 96, 83–98 (2017).
Article PubMed CAS Google Scholar
- Ferreira, J. V., Soares, A. R., Ramalho, J. S., Pereira, P. & Girao, H. K63 linked ubiquitin chain formation is a signal for HIF1A degradation by chaperone-mediated autophagy. Sci. Rep. 5, 10210 (2015).
Article PubMed CAS Google Scholar
- Li, L. et al. Deacetylation of tumor-suppressor MST1 in Hippo pathway induces its degradation through HBXIP-elevated HDAC6 in promotion of breast cancer growth. Oncogene 35, 4048–4057 (2016).
Article PubMed CAS Google Scholar
- Chiang, H., Terlecky, S., Plant, C. & Dice, J. F. A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins. Science 246, 382–385 (1989). Identification of HSC70 as the chaperone for CMA.
Article PubMed CAS Google Scholar
- Ferreira, J. V. et al. STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy. Autophagy 9, 1349–1366 (2013).
Article PubMed CAS Google Scholar
- Agarraberes, F. & Dice, J. F. A molecular chaperone complex at the lysosomal membrane is required for protein translocation. J. Cell Sci. 114, 2491–2499 (2001).
PubMed CAS Google Scholar
- Arndt, V. et al. Chaperone-assisted selective autophagy is essential for muscle maintenance. Curr. Biol. 20, 143–148 (2010).
Article PubMed CAS Google Scholar
- Cuervo, A. M., Dice, J. F. & Knecht, E. A population of rat liver lysosomes responsible for the selective uptake and degradation of cytosolic proteins. J. Biol. Chem. 272, 5606–5615 (1997).
Article PubMed CAS Google Scholar
- Salvador, N., Aguado, C., Horst, M. & Knecht, E. Import of a cytosolic protein into lysosomes by chaperone-mediated autophagy depends on its folding state. J. Biol. Chem. 275, 27447–27456 (2000).
PubMed CAS Google Scholar
- Agarraberes, F., Terlecky, S. & Dice, J. An intralysosomal hsp70 is required for a selective pathway of lysosomal protein degradation. J. Cell Biol. 137, 825–834 (1997).
Article PubMed PubMed Central CAS Google Scholar
- Kaushik, S., Massey, A., Mizushima, N. & Cuervo, A. M. Constitutive activation of chaperone-mediated autophagy in cells with impaired macroautophagy. Mol. Biol. Cell 19, 2179–2192 (2008).
Article PubMed PubMed Central CAS Google Scholar
- Cuervo, A. M. & Dice, J. F. A receptor for the selective uptake and degradation of proteins by lysosomes. Science 273, 501–503 (1996). Identification of the lysosomal membrane receptor for CMA.
Article PubMed CAS Google Scholar
- Cuervo, A. M., Knecht, E., Terlecky, S. R. & Dice, J. F. Activation of a selective pathway of lysosomal proteolysis in rat liver by prolonged starvation. Am. J. Physiol. 269, C1200–C1208 (1995).
Article PubMed CAS Google Scholar
- Cuervo, A. M. & Dice, J. F. Unique properties of lamp2a compared to other lamp2 isoforms. J. Cell Sci. 113, 4441–4450 (2000).
PubMed CAS Google Scholar
- Li, J. & Pfeffer, S. R. Lysosomal membrane glycoproteins bind cholesterol and contribute to lysosomal cholesterol export. eLife 5, e21635 (2016).
Article PubMed PubMed Central Google Scholar
- Cuervo, A. M. & Dice, J. F. Regulation of lamp2a levels in the lysosomal membrane. Traffic 1, 570–583 (2000).
Article PubMed CAS Google Scholar
- Rout, A. K., Strub, M. P., Piszczek, G. & Tjandra, N. Structure of transmembrane domain of lysosome-associated membrane protein type 2a (LAMP-2A) reveals key features for substrate specificity in chaperone-mediated autophagy. J. Biol. Chem. 289, 35111–35123 (2014).
Article PubMed PubMed Central CAS Google Scholar
- Kiffin, R., Christian, C., Knecht, E. & Cuervo, A. M. Activation of chaperone-mediated autophagy during oxidative stress. Mol. Biol. Cell 15, 4829–4840 (2004).
Article PubMed PubMed Central CAS Google Scholar
- Hubbi, M. E. et al. Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1alpha to promote cell-cycle progression. Proc. Natl Acad. Sci. USA 111, E3325–E3334 (2014).
Article PubMed PubMed Central CAS Google Scholar
- Anguiano, J. et al. Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives. Nat. Chem. Biol. 9, 374–382 (2013).
Article PubMed PubMed Central CAS Google Scholar
- Sardiello, M. et al. A gene network regulating lysosomal biogenesis and function. Science 325, 473–477 (2009).
Article PubMed CAS Google Scholar
- Kaushik, S., Massey, A. C. & Cuervo, A. M. Lysosome membrane lipid microdomains: novel regulators of chaperone-mediated autophagy. EMBO J. 25, 3921–3933 (2006). Identification of the mechanisms that determine LAMP2A stability in lysosomes.
Article PubMed PubMed Central CAS Google Scholar
- Wilke, S., Krausze, J. & Bussow, K. Crystal structure of the conserved domain of the DC lysosomal associated membrane protein: implications for the lysosomal glycocalyx. BMC Biol. 10, 62 (2012).
Article PubMed PubMed Central CAS Google Scholar
- Cuervo, A. M., Mann, L., Bonten, E. J., d’Azzo, A. & Dice, J. F. Cathepsin A regulates chaperone-mediated autophagy through cleavage of the lysosomal receptor. EMBO J. 22, 12–19 (2003).
Article Google Scholar
- Rodriguez-Navarro, J. A. et al. Inhibitory effect of dietary lipids on chaperone-mediated autophagy. Proc. Natl Acad. Sci. USA 109, E705–E714 (2012).
Article PubMed PubMed Central Google Scholar
- Kiffin, R. et al. Altered dynamics of the lysosomal receptor for chaperone-mediated autophagy with age. J. Cell Sci. 120, 782–791 (2007).
Article PubMed CAS Google Scholar
- Napolitano, G. et al. Impairment of chaperone-mediated autophagy leads to selective lysosomal degradation defects in the lysosomal storage disease cystinosis. EMBO Mol. Med. 7, 158–174 (2015).
Article PubMed PubMed Central CAS Google Scholar
- Zhang, J. et al. Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A. J. Biol. Chem. 292, 10328–10346 (2017).
Article PubMed CAS PubMed Central Google Scholar
- Tang, F. L. et al. VPS35 in dopamine neurons is required for endosome-to-Golgi retrieval of Lamp2a, a receptor of chaperone-mediated autophagy that is critical for alpha-synuclein degradation and prevention of pathogenesis of Parkinson’s disease. J. Neurosci. 35, 10613–10628 (2015).
Article PubMed PubMed Central CAS Google Scholar
- Koga, H., Martinez-Vicente, M., Macian, F., Verkhusha, V. V. & Cuervo, A. M. A photoconvertible fluorescent reporter to track chaperone-mediated autophagy. Nat. Commun. 2, 386 (2011).
Article PubMed PubMed Central CAS Google Scholar
- Dohi, E. et al. Hypoxic stress activates chaperone-mediated autophagy and modulates neuronal cell survival. Neurochem. Int. 60, 431–442 (2012).
Article PubMed CAS Google Scholar
- Finn, P. F. & Dice, J. F. Ketone bodies stimulate chaperone-mediated autophagy. J. Biol. Chem. 280, 25864–25870 (2005).
Article PubMed CAS Google Scholar
- Cuervo, A. M., Hildebrand, H., Bomhard, E. M. & Dice, J. F. Direct lysosomal uptake of alpha 2-microglobulin contributes to chemically induced nephropathy. Kidney Int. 55, 529–545 (1999).
Article PubMed CAS Google Scholar
- Martinez-Vicente, M. et al. Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy. J. Clin. Invest. 118, 777–788 (2008).
PubMed PubMed Central CAS Google Scholar
- Zhang, C. & Cuervo, A. M. Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function. Nat. Med. 14, 959–965 (2008).
Article PubMed PubMed Central CAS Google Scholar
- Mizushima, N., Yamamoto, A., Matsui, M., Yoshimori, T. & Ohsumi, Y. In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol. Biol. Cell 15, 1101–1111 (2004).
Article PubMed PubMed Central CAS Google Scholar
- Singh, R. et al. Autophagy regulates lipid metabolism. Nature 458, 1131–1135 (2009).
Article PubMed PubMed Central CAS Google Scholar
- Singh, V. et al. Salmonella co-opts host cell chaperone-mediated autophagy for intracellular growth. J. Biol. Chem. 292, 1847–1864 (2017).
Article PubMed CAS Google Scholar
- Wang, B. et al. Essential control of mitochondrial morphology and function by chaperone-mediated autophagy through degradation of PARK7. Autophagy 12, 1215–1228 (2016).
Article PubMed PubMed Central CAS Google Scholar
- Kaushik, S. & Cuervo, A. M. Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis. Nat. Cell Biol. 17, 759–770 (2015). Identification of the regulatory role of CMA in lipid metabolism.
Article PubMed PubMed Central CAS Google Scholar
- Lu, W. et al. Dual proteolytic pathways govern glycolysis and immune competence. Cell 159, 1578–1590 (2014).
Article PubMed PubMed Central CAS Google Scholar
- Cuervo, A. M., Hu, W., Lim, B. & Dice, J. F. IkappaB is a substrate for a selective pathway of lysosomal proteolysis. Mol. Biol. Cell 9, 1995–2010 (1998).
Article PubMed PubMed Central CAS Google Scholar
- Franch, H. A., Sooparb, S., Du, J. & Brown, N. S. A mechanism regulating proteolysis of specific proteins during renal tubular cell growth. J. Biol. Chem. 276, 19126–19131 (2001).
Article PubMed CAS Google Scholar
- Yang, Q. et al. Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy. Science 323, 124–127 (2009).
Article PubMed PubMed Central CAS Google Scholar
- Zhang, L. et al. Disruption of chaperone-mediated autophagy-dependent degradation of MEF2A by oxidative stress-induced lysosome destabilization. Autophagy 10, 1015–1035 (2014).
Article PubMed PubMed Central CAS Google Scholar
- Hu, M. M. et al. Sumoylation promotes the stability of the DNA sensor cGAS and the adaptor STING to regulate the kinetics of response to DNA virus. Immunity 45, 555–569 (2016).
Article PubMed CAS Google Scholar
- Cuervo, A. M. & Dice, J. F. Age-related decline in chaperone-mediated autophagy. J. Biol. Chem. 275, 31505–31513 (2000).
Article PubMed CAS Google Scholar
- Rodriguez-Muela, N. et al. Balance between autophagic pathways preserves retinal homeostasis. Aging Cell 12, 478–488 (2013).
Article PubMed CAS Google Scholar
- Cai, Z. et al. Chaperone-mediated autophagy: roles in neuroprotection. Neurosci. Bull. 31, 452–458 (2015).
Article PubMed PubMed Central CAS Google Scholar
- Cuervo, A. M. & Wong, E. Chaperone-mediated autophagy: roles in disease and aging. Cell Res. 24, 92–104 (2014).
Article PubMed CAS Google Scholar
- Mak, S. K., McCormack, A. L., Manning-Bog, A. B., Cuervo, A. M. & Di Monte, D. A. Lysosomal degradation of alpha-synuclein in vivo. J. Biol. Chem. 285, 13621–13629 (2010).
Article PubMed PubMed Central CAS Google Scholar
- Malkus, K. A. & Ischiropoulos, H. Regional deficiencies in chaperone-mediated autophagy underlie alpha-synuclein aggregation and neurodegeneration. Neurobiol. Dis. 46, 732–744 (2012).
Article PubMed PubMed Central CAS Google Scholar
- Vogiatzi, T., Xilouri, M., Vekrellis, K. & Stefanis, L. Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells. J. Biol. Chem. 283, 23542–23556 (2008).
Article PubMed PubMed Central CAS Google Scholar
- Orenstein, S. J. et al. Interplay of LRRK2 with chaperone-mediated autophagy. Nat. Neurosci. 16, 394–406 (2013).
Article PubMed PubMed Central CAS Google Scholar
- Kabuta, T., Furuta, A., Aoki, S., Furuta, K. & Wada, K. Aberrant interaction between Parkinson disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy. J. Biol. Chem. 283, 23731–23738 (2008).
Article PubMed PubMed Central CAS Google Scholar
- Andersson, F. I. et al. The effect of Parkinson’s-disease-associated mutations on the deubiquitinating enzyme UCH-L1. J. Mol. Biol. 407, 261–272 (2011).
Article PubMed CAS Google Scholar
- Wang, Y. et al. Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing. Hum. Mol. Genet. 18, 4153–4170 (2009).
Article PubMed PubMed Central CAS Google Scholar
- Huang, C. C. et al. Metabolism and mis-metabolism of the neuropathological signature protein TDP-43. J. Cell Sci. 127, 3024–3038 (2014).
Article PubMed CAS Google Scholar
- Bauer, P. O. et al. Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein. Nat. Biotechnol. 28, 256–263 (2010).
Article PubMed CAS Google Scholar
- Koga, H. et al. Constitutive upregulation of chaperone-mediated autophagy in Huntington’s disease. J. Neurosci. 31, 18492–18505 (2011).
Article PubMed PubMed Central CAS Google Scholar
- Qi, L. et al. The role of chaperone-mediated autophagy in huntingtin degradation. PLoS ONE 7, e46834 (2012).
Article PubMed PubMed Central CAS Google Scholar
- Xilouri, M., Vogiatzi, T., Vekrellis, K., Park, D. & Stefanis, L. Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy. PLoS ONE 4, e5515 (2009).
Article PubMed PubMed Central CAS Google Scholar
- Xilouri, M. et al. Impairment of chaperone-mediated autophagy induces dopaminergic neurodegeneration in rats. Autophagy 12, 2230–2247 (2016).
Article PubMed PubMed Central CAS Google Scholar
- Xilouri, M. et al. Boosting chaperone-mediated autophagy in vivo mitigates alpha-synuclein-induced neurodegeneration. Brain 136, 2130–2146 (2013). First evidence of antidegenerative effect of genetic enhancement of CMA.
Article PubMed Google Scholar
- Gan, L., Vargas, M. R., Johnson, D. A. & Johnson, J. A. Astrocyte-specific overexpression of Nrf2 delays motor pathology and synuclein aggregation throughout the CNS in the alpha-synuclein mutant (A53T) mouse model. J. Neurosci. 32, 17775–17787 (2012).
Article PubMed PubMed Central CAS Google Scholar
- Magalhaes, J. et al. Autophagic lysosome reformation dysfunction in glucocerebrosidase deficient cells: relevance to Parkinson disease. Hum. Mol. Genet. 25, 3432–3445 (2016).
Article PubMed PubMed Central CAS Google Scholar
- Alvarez-Erviti, L. et al. Chaperone-mediated autophagy markers in Parkinson disease brains. Arch. Neurol. 67, 1464–1472 (2010).
Article PubMed Google Scholar
- Murphy, K. E. et al. Reduced glucocerebrosidase is associated with increased alpha-synuclein in sporadic Parkinson’s disease. Brain 137, 834–848 (2014).
Article PubMed PubMed Central Google Scholar
- Pang, S., Chen, D., Zhang, A., Qin, X. & Yan, B. Genetic analysis of the LAMP-2 gene promoter in patients with sporadic Parkinson’s disease. Neurosci. Lett. 526, 63–67 (2012).
Article PubMed CAS Google Scholar
- Alvarez-Erviti, L. et al. Influence of microRNA deregulation on chaperone-mediated autophagy and alpha-synuclein pathology in Parkinson’s disease. Cell Death Dis. 4, e545 (2013).
Article PubMed PubMed Central CAS Google Scholar
- Park, J. S., Kim, D. H. & Yoon, S. Y. Regulation of amyloid precursor protein processing by its KFERQ motif. BMB Rep. 49, 337–342 (2016).
Article PubMed PubMed Central CAS Google Scholar
- Liu, H., Wang, P., Song, W. & Sun, X. Degradation of regulator of calcineurin 1 (RCAN1) is mediated by both chaperone-mediated autophagy and ubiquitin proteasome pathways. FASEB J. 23, 3383–3392 (2009).
Article PubMed CAS Google Scholar
- Rothenberg, C. et al. Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy. Hum. Mol. Genet. 19, 3219–3232 (2010).
Article PubMed PubMed Central CAS Google Scholar
- Saha, T. LAMP2A overexpression in breast tumors promotes cancer cell survival via chaperone-mediated autophagy. Autophagy 8, 1643–1656 (2012).
Article PubMed PubMed Central CAS Google Scholar
- Zhang, Y. et al. Acetylation targets HSD17B4 for degradation via the CMA pathway in response to estrone. Autophagy 13, 538–553 (2017).
Article PubMed PubMed Central CAS Google Scholar
- Du, C. et al. 5-Fluorouracil targets histone acetyltransferases p300/CBP in the treatment of colorectal cancer. Cancer Lett. 400, 183–193 (2017).
Article PubMed CAS Google Scholar
- Ding, Z. B. et al. Lamp2a is required for tumor growth and promotes tumor recurrence of hepatocellular carcinoma. Int. J. Oncol. 49, 2367–2376 (2016).
Article PubMed CAS Google Scholar
- Wu, J. H. et al. CMA down-regulates p53 expression through degradation of HMGB1 protein to inhibit irradiation-triggered apoptosis in hepatocellular carcinoma. World J. Gastroenterol. 23, 2308–2317 (2017).
Article PubMed PubMed Central Google Scholar
- Chava, S. et al. Chaperone-mediated autophagy compensates for impaired macroautophagy in the cirrhotic liver to promote hepatocellular carcinoma. Oncotarget 8, 40019–40036 (2017).
Article PubMed PubMed Central Google Scholar
- Guo, B. et al. M2 tumor-associated macrophages produce interleukin-17 to suppress oxaliplatin-induced apoptosis in hepatocellular carcinoma. Oncotarget 8, 44465–44476 (2017).
PubMed PubMed Central Google Scholar
- Ali, A. B., Nin, D. S., Tam, J. & Khan, M. Role of chaperone mediated autophagy (CMA) in the degradation of misfolded N-CoR protein in non-small cell lung cancer (NSCLC) cells. PLoS ONE 6, e25268 (2011).
Article PubMed PubMed Central CAS Google Scholar
- Vakifahmetoglu-Norberg, H. et al. Chaperone-mediated autophagy degrades mutant p53. Genes Dev. 27, 1718–1730 (2013).
Article PubMed PubMed Central CAS Google Scholar
- Xie, W. et al. Chaperone-mediated autophagy prevents apoptosis by degrading BBC3/PUMA. Autophagy 11, 1623–1635 (2015).
Article PubMed PubMed Central CAS Google Scholar
- Suzuki, J., Nakajima, W., Suzuki, H., Asano, Y. & Tanaka, N. Chaperone-mediated autophagy promotes lung cancer cell survival through selective stabilization of the pro-survival protein, MCL1. Biochem. Biophys. Res. Commun. 482, 1334–1340 (2017).
Article PubMed CAS Google Scholar
- Xia, H. G. et al. Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death. J. Cell Biol. 210, 705–716 (2015).
Article PubMed PubMed Central CAS Google Scholar
- Galan-Acosta, L., Xia, H., Yuan, J. & Vakifahmetoglu-Norberg, H. Activation of chaperone-mediated autophagy as a potential anticancer therapy. Autophagy 11, 2370–2371 (2015).
Article PubMed PubMed Central CAS Google Scholar
- Gomes, L. R., Menck, C. F. M. & Cuervo, A. M. Chaperone-mediated autophagy prevents cellular transformation by regulating MYC proteasomal degradation. Autophagy 13, 928–940 (2017).
Article PubMed PubMed Central CAS Google Scholar
- Lu, T. L. et al. Hispolon promotes MDM2 downregulation through chaperone-mediated autophagy. Biochem. Biophys. Res. Commun. 398, 26–31 (2010).
Article PubMed CAS Google Scholar
- Garg, A. D., Dudek, A. M. & Agostinis, P. Calreticulin surface exposure is abrogated in cells lacking, chaperone-mediated autophagy-essential gene, LAMP2A. Cell Death Dis. 4, e826 (2013).
Article PubMed PubMed Central CAS Google Scholar
- Kaushik, S. & Cuervo, A. M. Methods to monitor chaperone-mediated autophagy. Methods Enzymol. 452, 297–324 (2009).
Article PubMed PubMed Central CAS Google Scholar
- Li, P. et al. Degradation of AF1Q by chaperone-mediated autophagy. Exp. Cell Res. 327, 48–56 (2014).
Article PubMed CAS Google Scholar
- Gao, L. et al. Oxidation of survival factor MEF2D in neuronal death and Parkinson’s disease. Antioxid. Redox Signal 20, 2936–2948 (2014).
Article PubMed PubMed Central CAS Google Scholar
- Li, G. et al. Targeted suppression of chaperone-mediated autophagy by miR-320a promotes alpha-synuclein aggregation. Int. J. Mol. Sci. 15, 15845–15857 (2014).
Article PubMed PubMed Central CAS Google Scholar
- Wu, G. et al. Altered expression of autophagic genes in the peripheral leukocytes of patients with sporadic Parkinson’s disease. Brain Res. 1394, 105–111 (2011).
Article PubMed CAS Google Scholar
- Sala, G. et al. Reduced expression of the chaperone-mediated autophagy carrier hsc70 protein in lymphomonocytes of patients with Parkinson’s disease. Brain Res. 1546, 46–52 (2014).
Article PubMed CAS Google Scholar
- Wang, H. et al. Overexpression of PLK3 mediates the degradation of abnormal prion proteins dependent on chaperone-mediated autophagy. Mol. Neurobiol. 54, 4401–4413 (2017).
Article PubMed CAS Google Scholar
- Pedrozo, Z. et al. Cardiomyocyte ryanodine receptor degradation by chaperone-mediated autophagy. Cardiovasc. Res. 98, 277–285 (2013).
Article PubMed PubMed Central CAS Google Scholar
- Fidzianska, A., Walczak, E. & Walski, M. Abnormal chaperone-mediated autophagy (CMA) in cardiomyocytes of a boy with Danon disease. Folia Neuropathol. 45, 133–139 (2007).
PubMed Google Scholar
- Metrailler, S., Schorderet, D. F. & Cottet, S. Early apoptosis of rod photoreceptors in Rpe65(−/−) mice is associated with the upregulated expression of lysosomal-mediated autophagic genes. Exp. Eye Res. 96, 70–81 (2012).
Article PubMed CAS Google Scholar
- Li, Y., Lu, L., Luo, N., Wang, Y. Q. & Gao, H. M. Inhibition of PI3K/AKt/mTOR signaling pathway protects against d-galactosamine/lipopolysaccharide-induced acute liver failure by chaperone-mediated autophagy in rats. Biomed. Pharmacother. 92, 544–553 (2017).
Article PubMed CAS Google Scholar
- Das, S. et al. Purinergic receptor X7 is a key modulator of metabolic oxidative stress-mediated autophagy and inflammation in experimental nonalcoholic steatohepatitis. Am. J. Physiol. Gastrointest. Liver Physiol. 305, G950–G963 (2013).
Article PubMed PubMed Central CAS Google Scholar
- Sharma, S., Mells, J. E., Fu, P. P., Saxena, N. K. & Anania, F. A. GLP-1 analogs reduce hepatocyte steatosis and improve survival by enhancing the unfolded protein response and promoting macroautophagy. PLoS ONE 6, e25269 (2011).
Article PubMed PubMed Central CAS Google Scholar
- Cai, Y. et al. The detrimental role played by lipocalin-2 in alcoholic fatty liver in mice. Am. J. Pathol. 186, 2417–2428 (2016).
Article PubMed PubMed Central CAS Google Scholar
- Lee, C. H., Lee, K. H., Jang, A. H. & Yoo, C. G. The impact of autophagy on the cigarette smoke extract-induced apoptosis of bronchial epithelial cells. Tuberc. Respir. Dis. 80, 83–89 (2017).
Article Google Scholar
- Sooparb, S., Price, S. R., Shaoguang, J. & Franch, H. A. Suppression of chaperone-mediated autophagy in the renal cortex during acute diabetes mellitus. Kidney Int. 65, 2135–2144 (2004).
Article PubMed CAS Google Scholar
- Cacciottolo, M., Nogalska, A., D’Agostino, C., Engel, W. K. & Askanas, V. Chaperone-mediated autophagy components are upregulated in sporadic inclusion-body myositis muscle fibres. Neuropathol. Appl. Neurobiol. 39, 750–761 (2013).
Article PubMed CAS Google Scholar
- Su, M. et al. HDAC6 regulates the chaperone-mediated autophagy to prevent oxidative damage in injured neurons after experimental spinal cord injury. Oxid. Med. Cell Longev. 2016, 7263736 (2016).
PubMed Google Scholar
- Park, Y. et al. Chaperone-mediated autophagy after traumatic brain injury. J. Neurotrauma 32, 1449–1457 (2015).
Article PubMed PubMed Central Google Scholar
- Macri, C. et al. Modulation of deregulated chaperone-mediated autophagy by a phosphopeptide. Autophagy 11, 472–486 (2015).
Article PubMed PubMed Central Google Scholar
- Venugopal, B. et al. Chaperone-mediated autophagy is defective in mucolipidosis type IV. J. Cell. Physiol. 219, 344–353 (2009).
Article PubMed CAS Google Scholar