Autoantigens are translocated into small apoptotic bodies during early stages of apoptosis (original) (raw)

• Gaipl US, Kuhn A, Sheriff A, Munoz LE, Franz S, Voll RE et al. Clearance of apoptotic cells in human SLE. Curr Dir Autoimmun 2006; 9: 173–187.
  CAS PubMed Google Scholar
• Liu G, Wu C, Wu Y, Zhao Y . Phagocytosis of apoptotic cells and immune regulation. Scand J Immunol 2006; 64: 1–9.
  Article CAS Google Scholar
• Lorenz HM, Grunke M, Hieronymus T, Winkler S, Blank N, Rascu A et al. Hyporesponsiveness to gammac-chain cytokines in activated lymphocytes from patients with systemic lupus erythematosus leads to accelerated apoptosis. Eur J Immunol 2002; 32: 1253–1263.
  Article CAS Google Scholar
• White S, Rosen A . Apoptosis in systemic lupus erythematosus. Curr Opin Rheumatol 2003; 15: 557–562.
  Article CAS Google Scholar
• Lorenz HM, Grunke M, Hieronymus T, Herrmann M, Kuhnel A, Manger B et al. In vitro apoptosis and expression of apoptosis-related molecules in lymphocytes from patients with systemic lupus erythematosus and other autoimmune diseases. Arthritis Rheum 1997; 40: 306–317.
  Article CAS Google Scholar
• Perniok A, Wedekind F, Herrmann M, Specker C, Schneider M . High levels of circulating early apoptic peripheral blood mononuclear cells in systemic lupus erythematosus. Lupus 1998; 7: 113–118.
  Article CAS Google Scholar
• Licht R, Dieker JW, Jacobs CW, Tax WJ, Berden JH . Decreased phagocytosis of apoptotic cells in diseased SLE mice. J Autoimmun 2004; 22: 139–145.
  Article CAS Google Scholar
• Herrmann M, Voll RE, Zoller OM, Hagenhofer M, Ponner BB, Kalden JR . Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus. Arthritis Rheum 1998; 41: 1241–1250.
  Article CAS Google Scholar
• Gabler C, Blank N, Hieronymus T, Schiller M, Berden JH, Kalden JR et al. Extranuclear detection of histones and nucleosomes in activated human lymphoblasts as an early event in apoptosis. Ann Rheum Dis 2004; 63: 1135–1144.
  Article CAS Google Scholar
• Radic M, Marion T, Monestier M . Nucleosomes are exposed at the cell surface in apoptosis. J Immunol 2004; 172: 6692–6700.
  Article CAS Google Scholar
• Frisoni L, McPhie L, Colonna L, Sriram U, Monestier M, Gallucci S et al. Nuclear autoantigen translocation and autoantibody opsonization lead to increased dendritic cell phagocytosis and presentation of nuclear antigens: a novel pathogenic pathway for autoimmunity? J Immunol 2005; 175: 2692–2701.
  Article CAS Google Scholar
• Distler JH, Pisetsky DS, Huber LC, Kalden JR, Gay S, Distler O . Microparticles as regulators of inflammation: novel players of cellular crosstalk in the rheumatic diseases. Arthritis Rheum 2005; 52: 3337–3348.
  Article CAS Google Scholar
• Hugel B, Martinez MC, Kunzelmann C, Freyssinet JM . Membrane microparticles: two sides of the coin. Physiology (Bethesda) 2005; 20: 22–27.
  CAS Google Scholar
• Pilzer D, Gasser O, Moskovich O, Schifferli JA, Fishelson Z . Emission of membrane vesicles: roles in complement resistance, immunity and cancer. Springer Semin Immunopathol 2005; 27: 375–387.
  Article CAS Google Scholar
• Thery C, Duban L, Segura E, Veron P, Lantz O, Amigorena S . Indirect activation of naive CD4+ T cells by dendritic cell-derived exosomes. Nat Immunol 2002; 3: 1156–1162.
  Article CAS Google Scholar
• Segura E, Guerin C, Hogg N, Amigorena S, Thery C . CD8+ dendritic cells use LFA-1 to capture MHC-peptide complexes from exosomes in vivo. J Immunol 2007; 179: 1489–1496.
  Article CAS Google Scholar
• Cocca BA, Cline AM, Radic MZ . Blebs and apoptotic bodies are B cell autoantigens. J Immunol 2002; 169: 159–166.
  Article CAS Google Scholar
• Sebbagh M, Hamelin J, Bertoglio J, Solary E, Breard J . Direct cleavage of ROCK II by granzyme B induces target cell membrane blebbing in a caspase-independent manner. J Exp Med 2005; 201: 465–471.
  Article CAS Google Scholar
• Orlando KA, Stone NL, Pittman RN . Rho kinase regulates fragmentation and phagocytosis of apoptotic cells. Exp Cell Res 2006; 312: 5–15.
  Article CAS Google Scholar
• Lane JD, Allan VJ, Woodman PG . Active relocation of chromatin and endoplasmic reticulum into blebs in late apoptotic cells. J Cell Sci 2005; 118: 4059–4071.
  Article CAS Google Scholar
• Cline AM, Radic MZ . Apoptosis, subcellular particles, and autoimmunity. Clin Immunol 2004; 112: 175–182.
  Article CAS Google Scholar
• Fadeel B . Plasma membrane alterations during apoptosis: role in corpse clearance. Antioxid Redox Signal 2004; 6: 269–275.
  Article CAS Google Scholar
• Geske FJ, Monks J, Lehman L, Fadok VA . The role of the macrophage in apoptosis: hunter, gatherer, and regulator. Int J Hematol 2002; 76: 16–26.
  Article Google Scholar
• Voll RE, Herrmann M, Roth EA, Stach C, Kalden JR, Girkontaite I . Immunosuppressive effects of apoptotic cells. Nature 1997; 390: 350–351.
  Article CAS Google Scholar
• Gabler C, Kalden JR, Lorenz HM . The putative role of apoptosis-modified histones for the induction of autoimmunity in Systemic Lupus Erythematosus. Biochem Pharmacol 2003; 66: 1441–1446.
  Article CAS Google Scholar
• Cheung WL, Ajiro K, Samejima K, Kloc M, Cheung P, Mizzen CA et al. Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. Cell 2003; 113: 507–517.
  Article CAS Google Scholar
• Kroemer G, Reed JC . Mitochondrial control of cell death. Nat Med 2000; 6: 513–519.
  Article CAS Google Scholar
• Marchetti P, Hirsch T, Zamzami N, Castedo M, Decaudin D, Susin SA et al. Mitochondrial permeability transition triggers lymphocyte apoptosis. J Immunol 1996; 157: 4830–4836.
  CAS PubMed Google Scholar
• Martin S, Tesse A, Hugel B, Martinez MC, Morel O, Freyssinet JM et al. Shed membrane particles from T lymphocytes impair endothelial function and regulate endothelial protein expression. Circulation 2004; 109: 1653–1659.
  Article Google Scholar
• Qian Y, Wang H, Clarke SH . Impaired clearance of apoptotic cells induces the activation of autoreactive anti-Sm marginal zone and B-1 B cells. J Immunol 2004; 172: 625–635.
  Article CAS Google Scholar
• Radic MZ, Shah K, Zhang W, Lu Q, Lemke G, Hilliard GM . Heterogeneous nuclear ribonucleoprotein P2 is an autoantibody target in mice deficient for Mer, Axl, and Tyro3 receptor tyrosine kinases. J Immunol 2006; 176: 68–74.
  Article CAS Google Scholar
• Heyder P, Bekeredjian-Ding I, Parcina M, Blank N, Ho AD, Herrmann M et al. Purified apoptotic bodies stimulate plasmacytoid dendritic cells to produce IFN-alpha. Autoimmunity 2007; 40: 331–332.
  Article CAS Google Scholar
• Lorenz HM, Hieronymus T, Grunke M, Manger B, Kalden JR . Differential role for IL-2 and IL-15 in the inhibition of apoptosis in short-term activated human lymphocytes. Scand J Immunol 1997; 45: 660–669.
  Article CAS Google Scholar
• Hieronymus T, Blank N, Gruenke M, Winkler S, Haas JP, Kalden JR et al. CD 95-independent mechanisms of IL-2 deprivation-induced apoptosis in activated human lymphocytes. Cell Death Differ 2000; 7: 538–547.
  Article CAS Google Scholar
• Thery C, Boussac M, Veron P, Ricciardi-Castagnoli P, Raposo G, Garin J et al. Proteomic analysis of dendritic cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic vesicles. J Immunol 2001; 166: 7309–7318.
  Article CAS Google Scholar
• Riemekasten G, Hahn BH . Key autoantigens in SLE. Rheumatology (Oxford) 2005; 44: 975–982.
  Article CAS Google Scholar
• Nicoletti I, Migliorati G, Pagliacci MC, Grignani F, Riccardi C . A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 1991; 139: 271–279.
  Article CAS Google Scholar
• Koopman G, Reutelingsperger CP, Kuijten GA, Keehnen RM, Pals ST, van Oers MH . Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood 1994; 84: 1415–1420.
  CAS PubMed Google Scholar