Wade PA, Gegonne A, Jones PL, et al. Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation. Nat Genet. 1999;23:62–66. ArticleCASPubMed Google Scholar
Wade PA, Jones PL, Vermaak D, et al. A multiple subunit Mi-2 histone deacetylase from Xenopus laevis cofractionates with an associated Snf2 superfamily ATPase. Curr Biol. 1998;8:843–846. ArticleCASPubMed Google Scholar
Zhang Y, Ng HH, Erdjument-Bromage H, et al. Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev. 1999;13:1924–1935. ArticleCASPubMedPubMed Central Google Scholar
Sakai H, Urano T, Ookata K, et al. MBD3 and HDAC1, two components of the NuRD complex, are localized at Aurora-A-positive centrosomes in M phase. J Biol Chem. 2002;277:48714–48723. ArticleCASPubMed Google Scholar
Costello JF, Fruhwald MC, Smiraglia DJ, et al. Aberrant CpG-island methylation has non-random and tumour-type-specific patterns [see comments]. Nat Genet. 2000;24:132–138. ArticleCASPubMed Google Scholar
Baylin SB, Herman JG, Graff JR, et al. Alterations in DNA methylation: a fundamental aspect of neoplasia. Adv Cancer Res. 1998;72:141–196. ArticleCASPubMed Google Scholar
Sakai T, Toguchida J, Ohtani N, et al. Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene. Am J Hum Genet. 1991;48:880–888. CASPubMedPubMed Central Google Scholar
Myohanen SK, Baylin SB, Herman JG . Hypermethylation can selectively silence individual p16ink4A alleles in neoplasia. Cancer Res. 1998;58:591–593. CASPubMed Google Scholar
Batova A, Diccianni MB, Yu JC, et al. Frequent and selective methylation of p15 and deletion of both p15 and p16 in T-cell acute lymphoblastic leukemia. Cancer Res. 1997;57:832–836. CASPubMed Google Scholar
Esteller M, Fraga MF, Guo M, et al. DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis. Hum Mol Genet. 2001;10:3001–3007. ArticleCASPubMed Google Scholar
Herman JG, Baylin SB . Gene silencing in cancer in association with promoter hypermethylation. [see comment]. N Engl J Med. 2003;349:2042–2054. ArticleCASPubMed Google Scholar
Baylin SB, Herman JG . DNA hypermethylation in tumorigenesis: epigenetics joins genetics. Trends Genet. 2000;16:168–174. ArticleCASPubMed Google Scholar
Fischer EH . Cell signaling by protein tyrosine phosphorylation. Adv Enzyme Regul. 1999;39:359–369. ArticleCASPubMed Google Scholar
Maroun CR, Naujokas MA, Holgado-Madruga M, et al. The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase. Mol Cell Biol. 2000;20:8513–8525. ArticleCASPubMedPubMed Central Google Scholar
Meng TC, Fukada T, Tonks NK . Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo. Mol Cell. 2002;9:387–399. ArticleCASPubMed Google Scholar
Palka HL, Park M, Tonks NK . Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1. J Biol Chem. 2003;278:5728–5735. ArticleCASPubMed Google Scholar
Hermiston ML, Xu Z, Majeti R, et al. Reciprocal regulation of lymphocyte activation by tyrosine kinases and phosphatases. J Clin Invest. 2002;109:9–14. ArticleCASPubMedPubMed Central Google Scholar
Gupta S, Radha V, Sudhakar C, et al. A nuclear protein tyrosine phosphatase activates p53 and induces caspase-1-dependent apoptosis. FEBS Lett. 2002;532:61–66. ArticleCASPubMed Google Scholar
Salmeen A, Andersen JN, Myers MP, et al. Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B. Mol Cell. 2000;6:1401–1412. ArticleCASPubMed Google Scholar
Alonso A, Sasin J, Bottini N, et al. Protein tyrosine phosphatases in the human genome. Cell. 2004;117:699–711. ArticleCASPubMed Google Scholar
Panagopoulos I, Pandis N, Thelin S, et al. The FHIT and PTPRG genes are deleted in benign proliferative breast disease associated with familial breast cancer and cytogenetic rearrangements of chromosome band 3p14. Cancer Res. 1996;56:4871–4875. CASPubMed Google Scholar
Zhang Y, Siebert R, Matthiesen P, et al. Cytogenetical assignment and physical mapping of the human R-PTP-kappa gene (PTPRK) to the putative tumor suppressor gene region 6q22.2–q22.3. Genomics. 1998;51:309–311. ArticleCASPubMed Google Scholar
Ruivenkamp CA, van Wezel T, Zanon C, et al. Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers. Nat Genet. 2002;31:295–300. ArticleCASPubMed Google Scholar
Wang Z, Shen D, Parsons DW, et al. Mutational analysis of the tyrosine phosphatome in colorectal cancers. Science. 2004;304:1164–1166. ArticleCASPubMed Google Scholar
Andersen JN, Jansen PG, Echwald SM, et al. A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage. FASEB J. 2004;18:8–30. ArticleCASPubMed Google Scholar
Ardini E, Agresti R, Tagliabue E, et al. Expression of protein tyrosine phosphatase alpha (RPTPalpha) in human breast cancer correlates with low tumor grade, and inhibits tumor cell growth in vitro and in vivo. Oncogene. 2000;19:4979–4987. ArticleCASPubMed Google Scholar
Motiwala T, Ghoshal K, Das A, et al. Suppression of the protein tyrosine phosphatase receptor type O gene (PTPRO) by methylation in hepatocellular carcinomas. Oncogene. 2003;22:6319–6331. ArticleCASPubMedPubMed Central Google Scholar
Motiwala T, Kutay H, Ghoshal K, et al. Protein tyrosine phosphatase receptor-type O (PTPRO) exhibits characteristics of a candidate tumor suppressor in human lung cancer. Proc Natl Acad Sci USA. 2004;101:13844–13849 Epub 12004 Sep 13848. ArticleCASPubMedPubMed Central Google Scholar
Imreh S, Klein G, Zabarovsky ER . Search for unknown tumor-antagonizing genes. Genes, Chromosomes Cancer. 2003;38:307–321. ArticleCASPubMed Google Scholar
Mori Y, Yin J, Sato F, et al. Identification of genes uniquely involved in frequent microsatellite instability colon carcinogenesis by expression profiling combined with epigenetic scanning. Cancer Res. 2004;64:2434–2438. ArticleCASPubMed Google Scholar
Oka T, Ouchida M, Koyama M, et al. Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas. Cancer Res. 2002;62:6390–6394. CASPubMed Google Scholar
Amoui M, Baylink DJ, Tillman JB, et al. Expression of a structurally unique osteoclastic protein-tyrosine phosphatase is driven by an alternative intronic, cell type-specific promoter. J Biol Chem. 2003;278:44273–44280. ArticleCASPubMed Google Scholar
Mancini DN, Singh SM, Archer TK, et al. Site-specific DNA methylation in the neurofibromatosis (NF1) promoter interferes with binding of CREB and SP1 transcription factors. Oncogene. 1999;18:4108–4119. ArticleCASPubMed Google Scholar
DiNardo DN, Butcher DT, Robinson DP, et al. Functional analysis of CpG methylation in the BRCA1 promoter region. Oncogene. 2001;20:5331–5340. ArticleCASPubMed Google Scholar
Santoro R, Grummt I . Molecular mechanisms mediating methylation-dependent silencing of ribosomal gene transcription. Mol Cell. 2001;8:719–725. ArticleCASPubMed Google Scholar
Kass SU, Wolffe AP . DNA methylation, nucleosomes and the inheritance of chromatin structure and function. Novartis Found Symp. 1998;214:22–35; discussion 36–50. CASPubMed Google Scholar
Ghoshal K, Majumder S, Datta J, et al. Role of human ribosomal RNA (rRNA) promoter methylation and of methyl-CpG-binding protein MBD2 in the suppression of rRNA gene expression. J Biol Chem. 2004;279:6783–6793. ArticleCASPubMed Google Scholar
Taylor SM, Jones PA . Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine. Cell. 1979;17:771–779. ArticleCASPubMed Google Scholar
Baylin SB . Reversal of gene silencing as a therapeutic target for cancer — roles for DNA methylation and its interdigitation with chromatin. Novartis Found Symp. 2004;259:226–233; discussion 234–227. CASPubMed Google Scholar
Karpf AR, Jones DA . Reactivating the expression of methylation silenced genes in human cancer. Oncogene. 2002;21:5496–5503. ArticleCASPubMed Google Scholar
Jain PK . Epigenetics: the role of methylation in the mechanism of action of tumor suppressor genes. Ann NY Acad Sci. 2003;983:71–83. ArticleCASPubMed Google Scholar
Majumder S, Ghoshal K, Datta J, et al. Role of de novo DNA methyltransferases and methyl CpG-binding proteins in gene silencing in a rat hepatoma. J Biol Chem. 2002;277:16048–16058. ArticleCASPubMed Google Scholar
Ghoshal K, Majumder S, Li Z, et al. Suppression of metallothionein gene expression in a rat hepatoma because of promoter-specific DNA methylation. J Biol Chem. 2000;275:539–547. ArticleCASPubMed Google Scholar
Creusot F, Acs G, Christman JK . Inhibition of DNA methyltransferase and induction of Friend erythroleukemia cell differentiation by 5-azacytidine and 5-aza-2′-deoxycytidine. J Biolog Chem. 1982;257:2041–2048. CAS Google Scholar
Christman JK . 5-Azacytidine and 5-aza-2′-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. Oncogene. 2002;21:5483–5495. ArticleCASPubMed Google Scholar
Claus R, Lubbert M . Epigenetic targets in hematopoietic malignancies. Oncogene. 2003;22:6489–6496. ArticleCASPubMed Google Scholar
Jones PA, Taylor SM, Wilson VL . Inhibition of DNA methylation by 5-azacytidine. Rec Results Cancer Res. 1983;84:202–211. CAS Google Scholar
Jeltsch A . Beyond Watson and Crick: DNA methylation and molecular enzymology of DNA methyltransferases [erratum appears in Chembiochem 2002 May 3;3(5):382]. Chembiochem:3:274–293. ArticleCASPubMed Google Scholar
Bestor TH . The DNA methyltransferases of mammals. Humn Mol Genet. 2000;9:2395–2402. ArticleCAS Google Scholar
Gius D, Cui H, Bradbury CM, et al. Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach. Cancer Cell. 2004;6:361–371. ArticleCASPubMed Google Scholar
Ghoshal K, Datta J, Majumder S, et al. Inhibitors of histone deacetylase and DNA methyltransferase synergistically activate the methylated metallothionein I promoter by activating the transcription factor MTF-1 and forming an open chromatin structure. Mol Cell Biol. 2002;22:8302–8319. ArticleCASPubMedPubMed Central Google Scholar
Suzuki H, Gabrielson E, Chen W, et al. A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer. [see comment]. Nat Genet. 2002;31:141–149. ArticleCASPubMed Google Scholar
Grunstein M . Histone acetylation in chromatin structure and transcription. Nature. 1997;389:349–352. ArticleCASPubMed Google Scholar
Lachner M, Jenuwein T . The many faces of histone lysine methylation. Curr Opin Cell Biol. 2002;14:286–298. ArticleCASPubMed Google Scholar
de Ruijter AJ, van Gennip AH, Caron HN, et al. Histone deacetylases (HDACs): characterization of the classical HDAC family. Biochem J. 2003;370:737–749. ArticleCASPubMedPubMed Central Google Scholar
Belinsky SA, Klinge DM, Stidley CA, et al. Inhibition of DNA methylation and histone deacetylation prevents murine lung cancer. Cancer Res. 2003;63:7089–7093. CASPubMed Google Scholar
Shaker S, Bernstein M, Momparler RL . Antineoplastic action of 5-aza-2′-deoxycytidine (Dacogen) and depsipeptide on Raji lymphoma cells. Oncol Rep. 2004;11:1253–1256. CASPubMed Google Scholar
Kouraklis G, Theocharis S . Histone deacetylase inhibitors and anticancer therapy. Curr Med Chem — Anti-Cancer Agents. 2002;2:477–484. ArticleCASPubMed Google Scholar
Cameron EE, Bachman KE, Myohanen S, et al. Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nat Genet. 1999;21:103–107. ArticleCASPubMed Google Scholar
Wharram BL, Goyal M, Gillespie PJ, et al. Altered podocyte structure in GLEPP1 (Ptpro)-deficient mice associated with hypertension and low glomerular filtration rate. J Clin Invest. 2000;106:1281–1290. ArticleCASPubMedPubMed Central Google Scholar
Xu GL, Bestor TH, Bourc”his D, et al. Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene. Nature. 1999;402:187–191. ArticleCASPubMed Google Scholar
Pogribny IP, Miller BJ, James SJ . Alterations in hepatic p53 gene methylation patterns during tumor progression with folate/methyl deficiency in the rat. Cancer Lett. 1997;115:31–38. ArticleCASPubMed Google Scholar
Baylin S, Bestor TH . Altered methylation patterns in cancer cell genomes: cause or consequence? Cancer Cell. 2002;1:299–305. ArticleCASPubMed Google Scholar