Anti-inflammatory effect of virgin olive oil in stable coronary disease patients: a randomized, crossover, controlled trial (original) (raw)
References
- Beauchamp GK, Keast RS, Morel D, Lin J, Pika J, Han Q et al. (2005). Phytochemistry: ibuprofen-like activity in extra-virgin olive oil. Nature 437, 45–46.
Article CAS Google Scholar - Berliner JA, Territo MC, Sevanian A, Kim JA, Bamshad B, Esterson M et al. (1990). Minimally modified low density lipoprotein stimulates monocyte endothelial interactions. J Clin Invest 85, 1260–1266.
Article CAS Google Scholar - Bogani P, Galli C, Villa M, Visioli F (2007). Postprandial anti-inflammatory and antioxidant effects of extra virgin olive oil. Atherosclerosis 190, 181–186.
Article CAS Google Scholar - Carluccio MA, Siculella L, Ancora MA, Massaro M, Scoditti E, Storelli C et al. (2003). Olive oil and red wine antioxidant polyphenols inhibit endothelial activation: antiatherogenic properties of Mediterranean diet phytochemicals. Arterioscler Thromb Vasc Biol 23, 622–629.
Article CAS Google Scholar - Covas MI, Nyyssönen K, Poulsen HE, Kaikkonen J, Zunft HJF, Kiesewetter H et al. (2006a). The effect of polyphenols in olive oil on heart disease risk factors. Ann Int Med 145, 333–341.
Article CAS Google Scholar - Covas MI, Ruiz-Gutiérrez V, de la Torre R, Kafatos A, Lamuela-Raventós R, Osada J et al. (2006b). Olive oil minor components: evidence to date of health benefits in humans. Nutr Rev 64 (Supplement 1), 20–30.
Article Google Scholar - Elosua R, Marrugat J, Molina L, Pons S, Pujol E (1994). Validation of the minnesota leisure time physical activity questionnaire in spanish men. The MARATHOM Investigators. Am J Epidemiol 139, 1197–1209.
Article CAS Google Scholar - Esposito K, Marfella R, Ciotola M, Di Palo C, Giugliano F, Giugliano G et al. (2004). Effect of a mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial. JAMA 292, 1440–1446.
Article CAS Google Scholar - Estruch R, Martínez-González MA, Corella D, Salas-Salvadó J, Ruiz-Gutiérrez V, Covas MI et al. (2006). Effects of a mediterranean-style diet on cardiovascular risk factors: a randomized trial. Ann Int Med 145, 1–11.
Article Google Scholar - Fito M, Cladellas M, de la TR, Marti J, Alcantara M, Pujadas-Bastardes M et al. (2005). Antioxidant effect of virgin olive oil in patients with stable coronary heart disease: a randomized, crossover, controlled, clinical trial. Atherosclerosis 181, 149–158.
Article CAS Google Scholar - Helsing E (1995). Traditional diets and disease patterns of the Mediterranean, circa 1960. Am J Clin Nutr 61, 1329S–1337S.
Article CAS Google Scholar - Kim JA, Territo MC, Wayner E, Carlos TM, Parhami F, Smith CW et al. (1994). Partial characterization of leukocyte binding molecules on endothelial cells induced by minimally oxidized LDL. Arterioscler Thromb 14, 427–433.
Article Google Scholar - Kris-Etherton PM (1999). Monounsaturated fatty acids and risk of cardiovascular disease. Circulation 100, 1253–1258.
Article CAS Google Scholar - Leger CL, Carbonneau MA, Michel F, Mas E, Monnier L, Cristol JP et al. (2005). A thromboxane effect of a hydroxytyrosol-rich olive oil wastewater extract in patients with uncomplicated type I diabetes. Eur J Clin Nutr 59, 727–730.
Article CAS Google Scholar - Miró-Casas E, Covas MI, Fitó M, Farré-Albadalejo M, Marrugat J, de la Torre R (2003). Tyrosol and hydroxytyrosol are absorbed from moderate and sustained doses of virgin olive oil in humans. Eur J Clin Nutr 57, 186–190.
Article Google Scholar - Murase T, Kume N, Hase T, Shibuya Y, Nishizawa Y, Tokimitsu I et al. (1999). Gallates inhibit cytokine-induced nuclear translocation of NF-kappaB and expression of leukocyte adhesion molecules in vascular endothelial cells. Arterioscler Thromb Vasc Biol 19, 1412–1420.
Article CAS Google Scholar - Perona JS, Cabello-Moruno R, Ruiz-Gutierrez V (2006). The role of virgin olive oil components in the modulation of endothelial function. J Nutr Biochem 17, 429–445.
Article CAS Google Scholar - Ross R (1999). Atherosclerosis – an inflammatory disease. N Engl J Med 340, 115–126.
Article CAS Google Scholar - Schroder H, Covas MI, Marrugat J, Vila J, Pena A, Alcantara M et al. (2001). Use of a three-day estimated food record, a 72-h recall and a food- frequency questionnaire for dietary assessment in a Mediterranean Spanish population. Clin Nutr 20, 429–437.
Article CAS Google Scholar - Tsimikas S, Philis-Tsimikas A, Alexopoulos S, Sigari F, Lee C, Reaven PD (1999). LDL isolated from Greek subjects on a typical diet or from American subjects on an oleate-supplemented diet induces less monocyte chemotaxis and adhesion when exposed to oxidative stress. Arterioscler, Thromb Vasc Biol 19, 122–130.
Article CAS Google Scholar - Tunstall-Pedoe H, Kuulasmaa K, Mahonen M, Tolonen H, Ruokokoski E, Amouyel P (1999). Contribution of trends in survival and coronary-event rates to changes in coronary heart disease mortality: 10-year results from 37 WHO MONICA project populations. Monitoring trends and determinants in cardiovascular disease. Lancet 353, 1547–1557.
Article CAS Google Scholar - Tzoulaki I, Murray GD, Lee AJ, Rumley A, Lowe GD, Fowkes FG (2005). C-reactive protein, interleukin-6, and soluble adhesion molecules as predictors of progressive peripheral atherosclerosis in the general population: Edinburgh Artery Study. Circulation 112, 976–983.
Article CAS Google Scholar - Visioli F, Caruso D, Grande S, Bosisio R, Villa M, Galli G et al. (2005). Virgin Olive Oil Study (VOLOS): vasoprotective potential of extra virgin olive oil in mildly dyslipidemic patients. Eur J Nutr 44, 121–127.
Article CAS Google Scholar - Weinbrenner T, Cladellas M, Isabel CM, Fito M, Tomas M, Senti M et al. (2003). High oxidative stress in patients with stable coronary heart disease. Atherosclerosis 168, 99–106.
Article CAS Google Scholar - Wu D, Koga T, Martin KR, Meydani M (1999). Effect of vitamin E on human aortic endothelial cell production of chemokines and adhesion to monocytes. Atherosclerosis 147, 297–307.
Article CAS Google Scholar - Yaqoob P, Knapper JA, Webb DH, Williams CM, Newsholme EA, Calder PC (1998). Effect of olive oil on immune function in middle-aged men. Am J Clin Nutr 67, 129–135.
Article CAS Google Scholar
Acknowledgements
We thank the Ferderació Cooperatives Agràries de Catalunya for provide the olive oil used in the study. Fondo de investigación Sanitaria:FIS-PI02-0791 and partially supported by CIBER: CB-03-0028.
Author information
Authors and Affiliations
- Unitat de Lípids i Epidemiologia Cardiovascular, Institut Municipal d’Investigació Mèdica (IMIM), Barcelona, Spain
M Fitó, D Muñoz, H Schröder, M Alcántara, J Marrugat & M I Covas - Servei de Cardiologia, Hospital del Mar, Barcelona, Spain
M Cladellas, J Martí & J Bruguera - Universitat Autònoma de Barcelona, Barcelona, Spain
M Cladellas, J Martí & J Marrugat - Unitat de Recerca de Farmacologia, Institut Municipal d’Investigació Médica (IMIM), Barcelona, Spain
R de la Torre & M Pujadas-Bastardes - Universitat Pompeu Fabra, Barcelona, Spain
R de la Torre - Unitat de Nutrició i Bromatologia, Facultat de Farmàcia de Barcelona,
M C López-Sabater - Barcelona, Spain
M C López-Sabater
Authors
- M Fitó
You can also search for this author inPubMed Google Scholar - M Cladellas
You can also search for this author inPubMed Google Scholar - R de la Torre
You can also search for this author inPubMed Google Scholar - J Martí
You can also search for this author inPubMed Google Scholar - D Muñoz
You can also search for this author inPubMed Google Scholar - H Schröder
You can also search for this author inPubMed Google Scholar - M Alcántara
You can also search for this author inPubMed Google Scholar - M Pujadas-Bastardes
You can also search for this author inPubMed Google Scholar - J Marrugat
You can also search for this author inPubMed Google Scholar - M C López-Sabater
You can also search for this author inPubMed Google Scholar - J Bruguera
You can also search for this author inPubMed Google Scholar - M I Covas
You can also search for this author inPubMed Google Scholar
Consortia
the members of the SOLOS Investigators
Corresponding author
Correspondence toM Fitó.
Additional information
Guarantor: M Fitó.
SOLOS (Spanish Olive Oil Study) Study Investigators: Alcántara M, Covas MI, Fitó M, Marrugat J, Schröder H, Weinbrenner T, Alcántara M, Muñoz D, Guxens M (Unitat de Lipids i Epidemiologia Cardiovascular, Institut Muncipal d’Investigació Mèdica), de la Torre R, Farré M, Menoyo E, Pujadas-Bastardes M, Closas N, Khymenets O (Unitat de Farmacologia, Institut Muncipal d’Investigació Mèdica), and de la Torre-Boronat C, Gimeno E, Lamuela R and López MC (Departament de Bromatologia i Nutricio, Facultat de Farmacia, Universitat de Barcelona).
Contributors: Drs MF, MC, and MIC had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of analyses; Study concept and design: MF, MC, MIC, RT, JM; Acquisition of the data: MA, DM, MF, MC, MP-B, JM, HS; Analysis and interpretation of data: MF, MC, MIC, RT, MCL-S, JM; D_rafting of the manuscript_: MF, MC, MIC; Critical revision of the manuscript for important intellectual content: MA, MC, MIC, MF, RT, HS, JM, JM, MCL-S, JB, DM, MP-B; S_tatistical analyses:_ MF, MC; Obtained funding: MC, MIC, JB; Administrative, technical and material support: MF, JM, DM, MP-B, HS, MA.
Rights and permissions
About this article
Cite this article
Fitó, M., Cladellas, M., de la Torre, R. et al. Anti-inflammatory effect of virgin olive oil in stable coronary disease patients: a randomized, crossover, controlled trial.Eur J Clin Nutr 62, 570–574 (2008). https://doi.org/10.1038/sj.ejcn.1602724
- Received: 23 October 2006
- Revised: 12 January 2007
- Accepted: 05 February 2007
- Published: 21 March 2007
- Issue Date: April 2008
- DOI: https://doi.org/10.1038/sj.ejcn.1602724