Absence of the HIV-1 protective Δccr5 allele in most ethnic populations of India (original) (raw)

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• Published: 19 October 2001

European Journal of Human Genetics volume 9, pages 794–796 (2001)Cite this article

Abstract

Recent epidemiological data and projections indicate that HIV infection will spread rapidly in India. An allele Δ_ccr5_ of the β-chemokine receptor gene CCR5 has been found to confer protection against HIV-1. We find that this protective allele is absent in most ethnic populations of India, except some populations of the northern and western regions where this allele may have been introduced by Caucasian gene flow. The implications of this finding are discussed in the light of increasing HIV prevalence in India.

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Acknowledgements

We are grateful to the study participants and to our various collaborators who have helped us in the collection of blood samples. This study was supported in part by a grant from the Department of Biotechnology, Government of India.

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1. Anthropology & Human Genetics Unit, Indian Statistical Institute, 203 B.T. Road, Calcutta, 700 035, India
   Partha P Majumder & Badal Dey

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1. Partha P Majumder
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2. Badal Dey
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Correspondence toPartha P Majumder.

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Majumder, P., Dey, B. Absence of the HIV-1 protective Δ_ccr5_ allele in most ethnic populations of India.Eur J Hum Genet 9, 794–796 (2001). https://doi.org/10.1038/sj.ejhg.5200705

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• Received: 26 April 2001
• Revised: 21 June 2001
• Accepted: 28 June 2001
• Published: 19 October 2001
• Issue Date: 01 October 2001
• DOI: https://doi.org/10.1038/sj.ejhg.5200705

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