Evidence for a cluster of genes on chromosome 17q11–q21 controlling susceptibility to tuberculosis and leprosy in Brazilians (original) (raw)

• Fine PEM . Immunogenetics of susceptibility to leprosy, tuberculosis, and leishmaniasis. An epidemiological perspective. Int J Leprosy 1981; 49: 437–454.
  CAS Google Scholar
• Newport MJ, Blackwell JM . Genetic susceptibility to tuberculosis. Baillier's Clin Infect Dis Mycobact Dis 1997; 4: 207–230.
  Google Scholar
• Blackwell JM . Genetic susceptibility to leishmanial infections: studies in mice and man. Parasitology 1996; 112: S67–S74.
  Article Google Scholar
• Blackwell JM, Black GF, Peacock CS et al. Immunogenetics of leishmanial and mycobacterial infections: the Belem Family Study. Phil Trans R Soc B 1997; 352: 1331–1345.
  Article CAS Google Scholar
• Roberts M, Mock BA, Blackwell JM . Mapping of genes controlling Leishmania major infection in CXS recombinant inbred mice. Eur J Immunogenet 1993; 20: 349–362.
  Article CAS Google Scholar
• Mock B, Blackwell J, Hilgers J, Potter M, Nacy C . Genetic control of Leishmania major infection in congenic, recombinant inbred and F2 populations of mice. Eur J Immunogenet 1993; 20: 335–348.
  Article CAS Google Scholar
• Bradley DJ . Genetic control of natural resistance to Leishmania donovani. Nature 1974; 250: 353–354.
  Article CAS Google Scholar
• Bradley DJ, Kirkley J . Regulation of Leishmania populations within the host. I. The variable course of Leishmania donovani infections in mice. Clin Exp Immunol 1977; 30: 119–129.
  CAS PubMed PubMed Central Google Scholar
• Bradley DJ . Regulation of Leishmania populations within the host. II. Genetic control of acute susceptibility of mice to Leishmania donovani infection. Clin Exp Immunol 1977; 30: 130–140.
  CAS PubMed PubMed Central Google Scholar
• Bradley DJ, Taylor BA, Blackwell J, Evans EP, Freeman J . Regulation of Leishmania populations within the host. III. Mapping of the locus controlling susceptibility to visceral leishmaniasis in the mouse. Clin Exp Immunol 1979; 37: 7–14.
  CAS PubMed PubMed Central Google Scholar
• Gros P, Skamene E, Forget A . Genetic control of natural resistance to Mycobacterium bovis (BCG) in mice. J Immunol 1981; 127: 2417–2421.
  CAS PubMed Google Scholar
• Brown IN, Glynn AA, Plant J . Inbred mouse strain resistance to Mycobacterium lepraemurium follows the Ity/Lsh pattern. Immunology 1982; 47: 149–156.
  CAS PubMed PubMed Central Google Scholar
• Skamene E, Gros P, Forget A, Patel PJ, Nesbitt MN . Regulation of resistance to leprosy by chromosome 1 locus in the mouse. Immunogenetics 1984; 19: 117–124.
  Article CAS Google Scholar
• Goto Y, Buschman E, Skamene E . Regulation of host resistance to Mycobacterium intracellulare in vivo and in vitro by the Bcg gene. Immunogenetics 1989; 30: 218–221.
  Article CAS Google Scholar
• Shaw M-A, Collins A, Peacock CS et al. Evidence that genetic susceptibility to Mycobacterium tuberculosis in a Brazilian population is under oligogenic control: linkage study of the candidate genes NRAMP1 and TNFA. Tuberc Lung Dis 1997; 78: 35–45.
  Article CAS Google Scholar
• Bellamy R, Ruwende C, Corrah T, McAdam KPWJ, Whittle HC, Hill AVS . Variation in the NRAMP1 gene is associated with susceptibility to tuberculosis in West Africans. N Engl J Med 1998; 338: 640–644.
  Article CAS Google Scholar
• Greenwood CM, Fujiwara TM, Boothroyd LJ et al. Linkage of tuberculosis to chromosome 2q35 loci, including NRAMP1, in a large aboriginal Canadian family. Am J Hum Genet 2000; 67: 405–416.
  Article CAS Google Scholar
• Gao PS, Fujishima S, Mao XQ et al. Genetic variants of NRAMP1 and active tuberculosis in Japanese populations. International Tuberculosis Genetics Team. Clin Genet 2000; 58: 74–76.
  Article CAS Google Scholar
• Cervino AC, Lakiss S, Sow O, Hill AV . Allelic association between the NRAMP1 gene and susceptibility to tuberculosis in Guinea-Conakry. Ann Hum Genet 2000; 64: 507–512.
  Article CAS Google Scholar
• Ryu S, Park YK, Bai GH, Kim SJ, Park SN, Kang S . 3′UTR polymorphisms in the NRAMP1 gene are associated with susceptibility to tuberculosis in Koreans. Int J Tuberc Lung Dis 2000; 4: 577–580.
  CAS PubMed Google Scholar
• Awomoyi AA, Marchant A, Howson JM, McAdam KP, Blackwell JM, Newport MJ . Interleukin-10, polymorphism in SLC11A1 (formerly NRAMP1), and susceptibility to tuberculosis. J Infect Dis 2002; 186: 1804–1814.
  Article Google Scholar
• Liaw YS, Tsai-Wu JJ, Wu CH et al. Variations in the NRAMP1 gene and susceptibility of tuberculosis in Taiwanese. Int J Tuberc Lung Dis 2002; 6: 454–460.
  CAS PubMed Google Scholar
• Abel L, Sanchez FO, Oberti J et al. Susceptibility to leprosy is linked to the human NRAMP1 gene. J Infect Dis 1998; 177: 133–145.
  Article CAS Google Scholar
• Mohamed HS, Ibrahim ME, Miller EN et al. SLC11A1 (formerly NRAMP1) and susceptibility to visceral leishmaniasis in The Sudan. Eur J Hum Genet 2003 in press.
• Bucheton B, Abel L, Kheir MM et al. Genetic control of visceral leishmaniasis in a Sudanese population: candidate gene testing indicates a linkage to the NRAMP1 region. Genes Immun 2003; 4: 104–109.
  Article CAS Google Scholar
• Lander ES, Green P . Construction of multilocus genetic linkage maps in humans. Proc Natl Acad Sci USA 1987; 84: 2363–2367.
  Article CAS Google Scholar
• Matise TC, Gitlin JA . MAP-O-MAT: marker-based linkage mapping on the World Wide Web. Am J Hum Genet 1999; 65: A435.
  Google Scholar
• Spielman RS, McGinnis RE, Ewens WJ . Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 1993; 52: 506–516.
  CAS PubMed PubMed Central Google Scholar
• Cordell HJ, Clayton DG . A unified stepwise regression procedure for evaluating the relative effects of polymorphisms within a gene using case/control or family data: application to HLA in type 1 diabetes. Am J Hum Genet 2002; 70: 124–141.
  Article CAS Google Scholar
• Bland JM, Altman DG . Multiple significance tests: the Bonferroni method. BMJ 1995; 310: 170.
  Article CAS Google Scholar
• Wicker LS, Todd JA, Prins JB, Podolin PL, Renjilian RJ, Peterson LB . Resistance alleles at two non-major histocompatibility complex-linked insulin-dependent diabetes loci on chromosome 3, Idd3 and Idd10, protect nonobese diabetic mice from diabetes. J Exp Med 1994; 180: 1705–1713.
  Article CAS Google Scholar
• Podolin PL, Denny P, Lord CJ et al. Congenic mapping of the insulin-dependent diabetes (Idd) gene, Idd10, localizes two genes mediating the Idd10 effect and eliminates the candidate Fcgr1. J Immunol 1997; 159: 1835–1843.
  CAS PubMed Google Scholar
• Serreze DV, Bridgett M, Chapman HD, Chen E, Richard SD, Leiter EH . Subcongenic analysis of the Idd13 locus in NOD/Lt mice: evidence for several susceptibility genes including a possible diabetogenic role for beta 2-microglobulin. J Immunol 1998; 160: 1472–1478.
  CAS PubMed Google Scholar
• Morel L, Blenman KR, Croker BP, Wakeland EK . The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes. Proc Natl Acad Sci USA 2001; 98: 1787–1792.
  Article CAS Google Scholar
• Burgner D, Usen S, Rockett K et al. Nucleotide and haplotypic diversity of the NOS2A promoter region and its relationship to cerebral malaria. Hum Genet 2003; 112: 379–386.
  CAS PubMed Google Scholar
• Hobbs MR, Udhayakumar V, Levesque MC et al. A new NOS2 promoter polymorphism associated with increased nitric oxide production and protection from severe malaria in Tanzanian and Kenyan children. Lancet 2002; 360: 1468–1475.
  Article CAS Google Scholar
• Choi HS, Rai PR, Chu HW, Cool C, Chan ED . Analysis of nitric oxide synthase and nitrotyrosine expression in human pulmonary tuberculosis. Am J Respir Crit Care Med 2002; 166: 178–186.
  Article Google Scholar
• Tunctan B, Okur H, Calisir CH et al. Comparison of nitric oxide production by monocyte/macrophages in healthy subjects and patients with active pulmonary tuberculosis. Pharmacol Res 1998; 37: 219–226.
  Article CAS Google Scholar
• Rich EA, Torres M, Sada E, Finegan CK, Hamilton BD, Toossi Z . Mycobacterium tuberculosis (MTB)-stimulated production of nitric oxide by human alveolar macrophages and relationship of nitric oxide production to growth inhibition of MTB. Tuberc Lung Dis 1997; 78: 247–255.
  Article CAS Google Scholar
• Schon T, Hernandez-Pando RH, Negesse Y, Leekassa R, Sundqvist T, Britton S . Expression of inducible nitric oxide synthase and nitrotyrosine in borderline leprosy lesions. Br J Dermatol 2001; 145: 809–815.
  Article CAS Google Scholar
• Hieshima K, Imai T, Baba M et al. A novel human CC chemokine PARC that is most homologous to macrophage-inflammatory protein-1 alpha/LD78 alpha and chemotactic for T lymphocytes, but not for monocytes. J Immunol 1997; 159: 1140–1149.
  CAS PubMed Google Scholar
• Adema GJ, Hartgers F, Verstraten R et al. A dendritic-cell-derived C-C chemokine that preferentially attracts naive T cells. Nature 1997; 387: 713–717.
  Article CAS Google Scholar
• Kodelja V, Muller C, Politz O, Hakij N, Orfanos CE, Goerdt S . Alternative macrophage activation-associated CC-chemokine-1, a novel structural homologue of macrophage inflammatory protein-1 alpha with a Th2-associated expression pattern. J Immunol 1998; 160: 1411–1418.
  CAS PubMed Google Scholar
• Brown DH, Zwilling BS . Activation of the hypothalamic–pituitary–adrenal axis differentially affects the anti-mycobacterial activity of macrophages from BCG-resistant and susceptible mice. J Neuroimmunol 1994; 53: 181–187.
  Article CAS Google Scholar
• Brown DH, Sheridan J, Pearl D, Zwilling BS . Regulation of mycobacterial growth by the hypothalamus–pituitary–adrenal axis: differential responses of Mycobacterium bovis BCG-resistant and -susceptible mice. Infect Immun 1993; 61: 4793–4800.
  CAS PubMed PubMed Central Google Scholar
• Matsukawa A, Lukacs NW, Hogaboam CM, Chensue SW, Kunkel III SL . Chemokines and other mediators, 8. Chemokines and their receptors in cell-mediated immune responses in the lung. Microsc Res Tech 2001; 53: 298–306.
  Article CAS Google Scholar
• Ragno S, Romano M, Howell S, Pappin DJ, Jenner PJ, Colston MJ . Changes in gene expression in macrophages infected with Mycobacterium tuberculosis: a combined transcriptomic and proteomic approach. Immunology 2001; 104: 99–108.
  Article CAS Google Scholar
• Sadek MI, Sada E, Toossi Z, Schwander SK, Rich EA . Chemokines induced by infection of mononuclear phagocytes with mycobacteria and present in lung alveoli during active pulmonary tuberculosis. Am J Respir Cell Mol Biol 1998; 19: 513–521.
  Article CAS Google Scholar
• Lande R, Giacomini E, Grassi T et al. IFN-alphabeta released by _Mycobacterium tuberculosis_-infected human dendritic cells induces the expression of CXCL10: selective recruitment of NK and activated T cells. J Immunol 2003; 170: 1174–1182.
  Article CAS Google Scholar
• Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A . Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999; 401: 708–712.
  Article CAS Google Scholar
• Aickin M, Gensler H . Adjusting for multiple testing when reporting research results: the Bonferroni vs Holm methods [see comments] 1996; 86: 726–728.
• Knapp M . A note on power approximations for the transmission/disequilibrium test. Am J Hum Genet 1999; 64: 1177–1185.
  Article CAS Google Scholar
• Ridley DS, Jopling WH . Classification of leprosy according to immunity. A five-group system. Int J Lepr Mycobact Dis 1966; 34: 255–273.
  CAS Google Scholar
• Xu W, Liu L, Emson PC, Harrington CR, Charles IG . Evolution of a homopurine–homopyrimidine pentanucleotide repeat sequence upstream of the human inducible nitric oxide synthase gene. Gene 1997; 204: 165–170.
  Article CAS Google Scholar
• Weber JL, Kwitek AE, May PE, Wallace MR, Collins FS, Ledbetter DH . Dinucleotide repeat polymorphisms at the D17S250 and D17S261 loci. Nucleic Acids Res 1990; 18: 4640.
  PubMed PubMed Central Google Scholar
• Liu H, Chao D, Nakayama EE et al. Polymorphism in RANTES chemokine promoter affects HIV-1 disease progression. Proc Natl Acad Sci USA 1999; 96: 4581–4585.
  Article CAS Google Scholar
• An P, Nelson GW, Wang L et al. Modulating influence on HIV/AIDS by interacting RANTES gene variants. Proc Natl Acad Sci USA 2002; 99: 10002–10007.
  Article CAS Google Scholar
• Gonzalez E, Dhanda R, Bamshad M et al. Global survey of genetic variation in CCR5, RANTES, and MIP-1alpha: impact on the epidemiology of the HIV-1 pandemic. Proc Natl Acad Sci USA 2001; 98: 5199–5204.
  Article CAS Google Scholar
• Rovin BH, Lu L, Saxena R . A novel polymorphism in the MCP-1 gene regulatory region that influences MCP-1 expression. Biochem Biophys Res Commun 1999; 259: 344–348.
  Article CAS Google Scholar
• Holmans P, Clayton D . Efficiency of typing unaffected relatives in an affected sib-pair linkage study with single locus and multiple tightly-linked markers. Am J Hum Genet 1995; 37: 1221–1232.
  Google Scholar
• Gudbjartsson DF, Jonasson K, Frigge ML, Kong A . Allegro, a new computer program for multipoint linkage analysis. Nat Genet 2000; 25: 12–13.
  Article CAS Google Scholar
• Kong A, Cox NJ . Allele-sharing models: LOD scores and accurate linkage tests. Am J Hum Genet 1997; 61: 1179–1188.
  Article CAS Google Scholar
• Hedrick PW . Gametic disequilibrium measures: proceed with caution. Genetics 1987; 117: 331–341.
  CAS PubMed PubMed Central Google Scholar
• Stephens M, Smith NJ, Donnelly P . A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 2001; 68: 978–989.
  Article CAS Google Scholar
• Abecasis GR, Cookson WO . GOLD—graphical overview of linkage disequilibrium. Bioinformatics 2000; 16: 182–183.
  Article CAS Google Scholar
• Kun JF, Mordmuller B, Lell B, Lehman LG, Luckner D, Kremsner PG . Polymorphism in promoter region of inducible nitric oxide synthase gene and protection against malaria. Lancet 1998; 351: 265–266.
  Article CAS Google Scholar