Bennett J, Duan D, Engelhardt JF, Maguire AM . Real-time, noninvasive in vivo assessment of adeno-associated virus-mediated retinal transduction Invest Ophthalmol Vis Sci 1997 38: 2857–2863 CASPubMed Google Scholar
Contag PR, Olomu IN, Stevenson DK, Contag CH . Bioluminescent indicators in living mammals Nature Med 1998 4: 245–247 ArticleCAS Google Scholar
Phelps MC . PET: a biological imaging technique Neurochemical Res 1991 16: 929–940 ArticleCAS Google Scholar
Gambhir SS et al. Imaging of adenoviral directed herpes simplex virus type 1 thymidine kinase reporter gene expression in mice with radiolabeled ganciclovir J Nucl Med 1998 30: 2003–2011 Google Scholar
Barrio JR, Namavari M, Phelps ME, Satyamurthy N . Regioselective fluorination of substituted guanines with dilute F2: a facile entry to 8-fluoroguanine derivatives J Org Chem 1996 61: 6084–6085 ArticleCAS Google Scholar
Tjuvajev JG et al. Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: a potential method for monitoring clinical gene therapy Cancer Res 1996 56: 4087–4095 CASPubMed Google Scholar
Tjuvajev JG et al. Imaging herpes virus thymidine kinase gene transfer and expression by positron emission tomography Cancer Res 1998 58: 4333–4341 CASPubMed Google Scholar
Haberkorn U et al. Monitoring gene therapy with herpes simplex virus thymidine kinase in hepatoma cells: uptake of specific substrates J Nucl Med 1997 38: 287–294 CASPubMed Google Scholar
Haberkorn U et al. Monitoring of gene therapy with cytosine deaminase: in vitro studies using 3H-5-fluorocytosine J Nucl Med 1996 37: 87–94 CASPubMed Google Scholar
Monclus M et al. Development of a positron emission tomography radiopharmaceutical for imaging thymidine kinase gene expression: synthesis and in vitro evaluation of 9-{(3-[F-18]fluoro-1-hydroxy-2-propoxy)methyl}guanine Bioorg Med Chem Lett 1997 7: 1879–1882 ArticleCAS Google Scholar
Alauddin MM et al. 9-[(3-[18F]-fluoro-1-hydroxy-2-propoxy)methyl]guanine ([18F]-FHPG): a potential imaging agent of viral infection and gene therapy using PET Nuc Med Biol 1996 23: 787–792 ArticleCAS Google Scholar
Barrio JR et al. 3-(2′-[18F]Fluoroethyl)spiperone: in vivo biochemical and kinetic characterization in rodents, nonhuman primates, and humans J Cerbral Blood Flow Metab 1989 9: 830–839 ArticleCAS Google Scholar
Bahn MM et al. Models for in vivo kinetic interactions of dopamine D2 neuroreceptors and 3-(2′-[18F]Fluoroethyl)spiperone examined by positron emission tomography J Cerebral Blood Flow Metab 1989 9: 840–849 ArticleCAS Google Scholar
Satyamurthy N et al. 3-(2′-[18F]Fluoroethyl)spiperone, a potent dopamine antagonist: synthesis, structural analysis and in vivo utilization in humans Appl Radiat Isotopes Int J Radiat Appl Instrument Part A 1990 41: 113–129 ArticleCAS Google Scholar
Bunzow JR et al. Cloning and expression of a rat D2 dopamine receptor cDNA Nature 1988 367: 783–787 Article Google Scholar
Missale C et al. Dopamine receptors: from structure to function Physiol Rev 1998 78: 189–225 ArticleCAS Google Scholar
Creese I . Neurochemical, behavioral, and clinical perspectives. In: Coyle JT, Enna SJ, (eds). Neuroleptics Raven Press: New York 1983 208–211 Google Scholar
Shaked A et al. Adenovirus-mediated gene transfer in the transplant setting. II. Successful expression of transferred cDNA in syngeneic liver grafts Transplantation 1994 57: 1508–1511 ArticleCAS Google Scholar
Herz J, Girard RD . Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice Proc Natl Acad Sci USA 1993 90: 2812–2816 ArticleCAS Google Scholar
Cherry SR et al. MicroPET: a high resolution PET scanner for imaging small animals IEEE Trans Nucl Sci 1997 44: 1161–1166 ArticleCAS Google Scholar
Seeman P . Brain dopamine receptors Pharm Rev 1981 32: 229–313 Google Scholar
Neve KA, Henningsen RA, Bunzow JR, Civelli O . Functional characterization of a rat dopamine D-2 receptor cDNA expressed in a mammalian cell line Mol Pharmacol 1989 36: 446–451 CASPubMed Google Scholar
Johnson PL, Coussens PM, Danko AV, Shalloway D . Overexpressed pp60c-src can induce focus formation without complete transformation of NIH 3T3 cells Mol Cell Biol 1983 5: 1073–1083 Article Google Scholar
Phelps ME et al. Tomographic measurement of local cerebral glucose metabolic rate in humans with (F-18) 2-fluoro-2-deoxy-D-glucose: validation of method Ann Neurol 1979 6: 371–388 ArticleCAS Google Scholar
Ehrin E et al. Preparation of 11C-labelled raclopride, a new potent dopamine receptor antagonist: preliminary PET studies of cerebral dopamine receptors in the monkey Int J Appl Radiat Isot 1985 36: 269–273 ArticleCAS Google Scholar
Hall H et al. Raclopride, a new selective ligand for the dopamine-D2 receptors Prog Neuropsychopharmacol Biol Psychiatry 1988 12: 559–568 ArticleCAS Google Scholar
Hume SP et al. Quantitation of carbon-11-labeled raclopride in rat striatum using positron emission tomography Synapse 1992 12: 47–54 ArticleCAS Google Scholar
Wagner HN et al. Imaging dopamine receptors in the human brain by positron tomography Science 1983 221: 1264–1266 ArticleCAS Google Scholar
Kessler RM et al. High affinity dopamine D2 receptor radioligands. 1. Regional rat brain distribution of iodinated benzamides J Nucl Med 1991 32: 1593–1600 CASPubMed Google Scholar
Strange PG . Aspects of the structure of the D2 dopamine receptor TINS 1990 13: 373–378 CASPubMed Google Scholar
Neve KA et al. Pivotal role for aspartate-80 in the regulation of dopamine D2 receptor affinity for drugs and inhibition of adenylyl cyclase Mol Pharmacol 1991 39: 733–739 CASPubMed Google Scholar
Woodward R et al. Investigation of the role of conserved serine residues in the long form of the rat D2 dopamine receptor using site-directed mutagenesis J Neurochem 1996 66: 394–402 ArticleCAS Google Scholar
Cox BA et al. Contributions of conserved serine residues to the interactions of ligands with dopamine D2 receptors J Neurochem 1992 59: 627–635 ArticleCAS Google Scholar
No D, Yao TP, Evans RM . Ecdysone-inducible gene expression in mammalian cells and transgenic mice Proc Natl Acad Sci USA 1996 93: 3346–3351 ArticleCAS Google Scholar
Gossen M, Bujard H . Tight control of gene expression in mammalian cells by tetracycline-responsive promoters Proc Natl Acad Sci USA 1992 89: 5547–5551 ArticleCAS Google Scholar
Kistner A et al. Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice Proc Natl Acad Sci USA 1996 93: 10933–10938 ArticleCAS Google Scholar
Veelken H et al. Systematic evaluation of chimeric marker genes on dicistronic transcription units for regulated expression of transgenes in vitro and in vivoHum Gene Ther 1996 7: 1827–1836 ArticleCAS Google Scholar
Gurtu V, Yan G, Zhang G . IRES bicistronic expression vectors for efficient creation of stable mammalian cell lines Biochem Biophys Res Commun 1996 229: 295–298 ArticleCAS Google Scholar
Hsieh CL et al. Improved gene expression by a modified bicistronic retroviral vector Biochem Biophys Res Commun 1995 214: 910–917 ArticleCAS Google Scholar
Sokolic RA et al. A bicistronic retrovirus vector containing a picornavirus internal ribosome entry site allows for correction of X-linked CGD by selection for MDR1 expression Blood 1996 87: 42–50 CASPubMed Google Scholar
Gomez-Foix AM et al. Adenovirus-mediated transfer of the muscle glycogen phosphorylase gene into hepatocytes confers altered regulation of glycogen metabolism J Biol Chem 1992 267: 25129–25134 CASPubMed Google Scholar
Sambrook J, Fritsch EF, Maniatis T . Molecular Cloning: A Laboratory Manual Cold Spring Harbor Laboratory: Cold Spring Harbor, NY 1989 Google Scholar