The anticancer drug imatinib induces cellular autophagy (original) (raw)
Druker BJ, Tamura S, Buchdunger E, Ohno S, Segal GM, Fanning S et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med 1996; 2: 561–566. ArticleCASPubMed Google Scholar
Buchdunger E, Zimmermann J, Mett H, Meyer T, Muller M, Druker BJ et al. Inhibition of the Abl protein-tyrosine kinase in vitro by a 2-phenylaminopyrimidine derivative. Cancer Res 1996; 56: 1000–1004. Google Scholar
Heinrich MC, Griffith DJ, Druker BJ, Wait CL, Ott KA, Zigler AJ . Inhibition of c-kit receptor tyrosine kinase activity by STI571, a selective tyrosine kinase inhibitor. Blood 2000; 96: 925–932. CASPubMed Google Scholar
Dewar AL, Zannettino AC, Hughes TP, Lyons AB . Inhibition of c-fms by imatinib: expanding the spectrum of treatment. Cell Cycle 2005; 4: 851–853. ArticleCASPubMed Google Scholar
Kurzrock R, Kantarjian HM, Drucker BJ, Talpaz M . Philadelphia chromosome-positive leukemias: from basic mechanisms to molecular therapeutics. Ann Int Med 2003; 138: 819–830. ArticleCASPubMed Google Scholar
Pendergast AM . The Abl family kinases: mechanisms of regulation and signalling. Adv Cancer Res 2002; 85: 51–100. ArticleCASPubMed Google Scholar
Kilic T, Alberta J, Zdunek PR, Acar M, Iannarelli P, O’Reilly T et al. Intracranial inhibition of platelet-derived growth factor-mediated glioblastoma cell growth by an orally active kinase inhibitor of the 2-phenylaminopyrimidine class. Cancer Res 2000; 60: 5143–5150. CASPubMed Google Scholar
Russell J, Brady K, Burgan W, Cerra MA, Oswald KA, Camphausen K et al. STI571-mediated inhibition of Rad51 expression and enhancement of tumor cell radiosensitivity. Cancer Res 2003; 63: 7377–7383. CASPubMed Google Scholar
Netzer WJ, Dou F, Cai D, Veach D, Jean S, Li Y et al. Gleevec inhibits beta-amyloid production but not Notch cleavage. Proc Natl Acad Sci USA 2003; 100: 12444–12449. ArticleCASPubMedPubMed Central Google Scholar
Ertmer A, Gilch S, Yun SW, Flechsig E, Klebl B, Stein-Gerlach M et al. The tyrosine kinase inhibitor STI571 induces cellular clearance of PrPSc in prion-infected cells. J Biol Chem 2004; 279: 41918–41927. ArticleCASPubMed Google Scholar
Kabeya Y, Mizushima N, Ueno T, Yamamotot A, Kirisako T, Noda T et al. LC3, a mammalian homologue of yeast Apg8p is localized in autophagosome membranes after processing. EMBO J 2000; 19: 5720–5728. ArticleCASPubMedPubMed Central Google Scholar
Ito S, Karnovsky MJ . Formaledhyde-glutaraldehyde fixatives containing trinitro compounds. J Cell Biol 1968; 39: 168a–169a. Google Scholar
Blommaart EF, Luiken JJ, Meijer AJ . Autophagic proteolysis: control and specificity. Histochem J 1997; 29: 365–385. ArticleCASPubMed Google Scholar
Seglen PO, Bohley P . Autophagy and other vacuolar protein degradation mechanisms. Experientia 1992; 48: 158–172. ArticleCASPubMed Google Scholar
Hoyvik H, Gordon PB, Seglen PO . Use of a hydrolysable probe, [14C]lactose, to distinguish between pre-lysosomal and lysosomal steps in the autophagic pathway. Exp Cell Res 1986; 166: 1–14. ArticleCASPubMed Google Scholar
Yu JC, Lokker NA, Hollenbach S, Apatira M, Li J, Betz A et al. Efficacy of the novel selective platelet derived growth factor receptor antagonist CT52923 on cellular proliferation, migration, and suppression of neointima following vascular injury. J Pharmacol Exp Ther 2001; 298: 1172–1178. CASPubMed Google Scholar
Sun X, Layton JF, Elefanty A, Lieschke GJ . Comparison of effects of the tyrosine kinase inhibitors AG957, AG490 and STI571 on BCR-ABL-expressing cells, demonstrating synergy between AG490 and STI571. Blood 2001; 97: 2008–2015. ArticleCASPubMed Google Scholar
Klionsky DJ, Ohsumi Y . Vacuolar import of proteins and organelles from the cytoplasm. Annu Rev Cell Dev Biol 1999; 15: 1–32. ArticleCASPubMed Google Scholar
Yoshimori T . Autophagy : a regulated bulk degradation process inside cells. Biochem Biophys Res Commun 2004; 313: 453–458. ArticleCASPubMed Google Scholar
Otsuka H, Moskowitz M . Differences in the rates of protein degradation in untransformed and transformed cell lines. Exp Cell Res 1978; 112: 127–135. ArticleCASPubMed Google Scholar
Schwarze PE, Seglen PO . Reduced autophagic activity, improved protein balance and enhanced in vitro survival of hepatocytes isolated from carcinogen-treated rats. Exp Cell Res 1985; 157: 15–28. ArticleCASPubMed Google Scholar
Qu X, Yu J, Bhagat G, Furuya N, Hibshoosh H, Troxel A et al. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest 2003; 112: 1809–1820. ArticleCASPubMedPubMed Central Google Scholar
Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H et al. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 1999; 402: 672–676. ArticleCASPubMed Google Scholar
Cuervo AM . Autophagy: in sickness and in health. Trends Cell biol 2004; 14: 70–77. ArticlePubMed Google Scholar
Kerr JF, Wyllie AH, Currie AR . Apoptosis: a baxic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972; 26: 239–257. ArticleCASPubMedPubMed Central Google Scholar
Syntichaki P, Tavernakis N . Death by necrosis. Uncontrollable catastrophe, or is there order behind the chaos? EMBO Rep 2002; 3: 604–609. ArticleCASPubMedPubMed Central Google Scholar
Bursch W, Ellinger A, Kienzl H, Torok L, Pandey S, Sikorska M et al. Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: the role of autophagy. Carcinogenesis 1996; 17: 1595–1607. ArticleCASPubMed Google Scholar
Kanzawa T, Germano IM, Komata T, Ito H, Kondo Y, Kondo S . Role of autophagy in temozolomide-inducedcytotoxicity for malignant glioma cells. Cell Death Differ 2004; 11: 448–457. ArticleCASPubMed Google Scholar
Paglin S, Hollister T, Delohery T, Hackett N, McMahill M, Sphicas E et al. A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles. Cancer Res 2001; 61: 439–444. CASPubMed Google Scholar
Ito H, Daido S, Kanzawa T, Kondo S, Kondo Y . Radiation-induced autophagy is associated with LC3 and its inhibition sensitizes malignant glioma cells. Int J Oncol 2005; 26: 1401–1410. CASPubMed Google Scholar
Yao KC, Komata T, Kondo Y, Kanzawa T, Kondo S, Germano IM . Molecular response of human glioblastoma multiforme cells to ionizing radiation: cell cycle arrest modulation of the expression of cyclin-dependent kinase inhibitors, and autophagy. J Neurosurg 2003; 98: 378–384. ArticleCASPubMed Google Scholar
Shao Y, Gao Z, Marks PA, Jiang X . Apoptotic and autophagic cell death induced by histone deacetylase inhibitors. Proc Natl Acad Sci USA 2004; 101: 18030–18035. ArticleCASPubMedPubMed Central Google Scholar
Komata T, Kanzawa T, Nashimoto T, Aoki H, Endo S, Nameta M et al. Mild heat shock induces autophagic growth arrest, but not apoptosis in U251-MG and U87-MG human malignant glioma cells. J Neurooncol 2004; 68: 101–111. ArticlePubMed Google Scholar
Kanzawa T, Kondo Y, Ito H, Kondo S, Germano I . Induction of autophagic cell death in malignant glioma cells by arsenic trioxide. Cancer Res 2003; 63: 2103–2108. CASPubMed Google Scholar
Kanzawa T, Zhang L, Xiao L, Germano IM, Kondo Y, Kondo S . Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3. Oncogene 2005; 24: 980–991. ArticleCASPubMed Google Scholar
Opipari Jr AW, Tan L, Boitani AE, Sorenson DR, Aurora A, Liu JR . Resveratrol-induced autophagocytosis in ovarian cancer cells. Cancer Res 2004; 64: 696–703. ArticleCASPubMed Google Scholar
Ellington AA, Berhow M, Singletary KW . Induction of macroautophagy in human colon cancer cells by soybean B-group triterpenoid saponins. Carcinogenesis 2005; 26: 159–167. ArticleCASPubMed Google Scholar
Takeuchi H, Kondo Y, Fujiwara K, Kanzawa T, Aoki H, Mills GB et al. Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-phosphate kinase/protein kinase B inhibitors. Cancer Res 2005; 65: 3336–3346. ArticleCASPubMed Google Scholar
Ogier-Denis E, Codogno P . Autophagy: a barrier or an adaptive response to cancer. Biochim Biophys Acta 2003; 1603: 113–128. CASPubMed Google Scholar
Gozuacik D, Kimchi A . Autophagy as a cell death and tumor suppressor mechanism. Oncogene 2004; 23: 2891–2906. ArticleCASPubMed Google Scholar
Burchert A, Wang Y, Cai D, von Bubnoff N, Paschka P, Muller-Brusselbach S et al. Compensatory PI3-kinase/Akt/mTor activation regulates imatinib resistance development. Leukemia 2005; 19: 1774–1782. ArticleCASPubMed Google Scholar
Tsurutani J, West KA, Sayyah J, Gills JJ, Dennis PA . Inhibition of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway but not the MEK/ERK pathway attenuates laminin-mediated small cell lung cancer cellular survival and resistance to imatinib mesylate or chemotherapy. Cancer Res 2005; 65: 8423–8432. ArticleCASPubMed Google Scholar