Approaches to identify, clone, and express symbiont bioactive metabolite genes (original) (raw)
* Corresponding authors
a Scripps Institution of Oceanography, Marine Biology Research Division; Center for Marine Biotechnology and Biomedicine; and UCSD Cancer Center, University of California, San Diego, California 92093, USA
Abstract
Covering: 1981–2003
This review discusses approaches to identify, clone, and express bioactive metabolite genes from symbionts of marine invertebrates. Criteria for proving symbiotic origin of bioactive metabolites are presented, followed by a comprehensive, practically-oriented overview of techniques to be applied. The Bugula neritina/Endobugula sertula association is used as a primary example, but other symbioses are discussed. Thirty-six compounds are presented and 111 references are cited.
- This article is part of the themed collection:Marine Natural Products
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Article information
DOI
https://doi.org/10.1039/B302336M
Article type
Review Article
Submitted
22 Oct 2003
First published
15 Dec 2003
Download Citation
Nat. Prod. Rep., 2004,21, 122-142
Permissions
Approaches to identify, clone, and express symbiont bioactive metabolite genes
M. Hildebrand, L. E. Waggoner, G. E. Lim, K. H. Sharp, C. P. Ridley and M. G. Haygood,Nat. Prod. Rep., 2004, 21, 122DOI: 10.1039/B302336M
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