Development of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L–A hybrid design approach (original) (raw)
Shatarupa De,‡a Pratikkumar Rathod,‡ab Anibal R. Davalos,a Daniel A. Novoa,a Suneeta Paroly,c Viviana M. Torres,a Nisar Afzal,a Ravi S. Lankalapalli,§a Susan A. Rotenberg,a Emmanuel J. Chang,b Gopal Subramaniama and Sanjai Kumar*a
* Corresponding authors
a Department of Chemistry and Biochemistry, Queens College and the Graduate Center of the City University of New York, Queens, New York 11367-1597, USA
E-mail: Sanjai.Kumar@qc.cuny.edu
Fax: +1 718 997 5531
Tel: +1 718 997 4120
b Department of Chemistry, York College of the City University of New York, Jamaica, New York, USA
c Bard High School Early College Queens, 30-20 Thomson Avenue, Long Island City, New York, USA
Abstract
A hybrid-design approach is undertaken to develop a highly potent and selective inhibitor of human cathepsin L. Studies involving human breast carcinoma MDA-MB-231 cells establish that this inhibitor can successfully block intracellular cathepsin L activity, and retard the cell-migratory potential of these highly metastatic cells.
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Article information
DOI
https://doi.org/10.1039/C4CC04037F
Article type
Communication
Submitted
26 May 2014
Accepted
27 Jul 2014
First published
28 Jul 2014
Download Citation
Chem. Commun., 2014,50, 10875-10878
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Development of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L–A hybrid design approach
D. Dana, S. De, P. Rathod, A. R. Davalos, D. A. Novoa, S. Paroly, V. M. Torres, N. Afzal, R. S. Lankalapalli, S. A. Rotenberg, E. J. Chang, G. Subramaniam and S. Kumar,Chem. Commun., 2014, 50, 10875DOI: 10.1039/C4CC04037F
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