Progress and perspectives in bioactive agent delivery via electrospun vascular grafts (original) (raw)

* Corresponding authors

a Department of Pharmaceutical Technology, Faculty of Pharmacy, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznan, Poland
E-mail: mrychter@ump.edu.pl

b NanoBioMedical Center, Adam Mickiewicz University Poznan, Umultowska 85, 61-614 Poznan, Poland

Abstract

The review discusses the progress in the design and synthesis of bioactive agents incorporated into vascular grafts obtained by the electrospinning process. Electrospun fibers can be applied as an artificial extracellular matrix for tissue engineering and drug delivery, improving tissue regeneration and therapeutic outcomes. A large number of active substances are loaded into the fibers, such as growth factors, heparin, NO donors, statins, antibiotics or anti-inflammatory agents. There are various methods for bioactive substance incorporation including direct blending, emulsion, and coaxial electrospinning as well as covalent and non-covalent binding of the bioactive molecules to the fiber surface. The release mechanism of the drug depends on the synthesis route, active substance properties, and polymer matrix nature. The electrospun materials represent a very promising building block for the fabrication of effective vascular prosthesis in the near future.

Graphical abstract: Progress and perspectives in bioactive agent delivery via electrospun vascular grafts

This article is part of the themed collection:2017 Review articles

This article is Open Access

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Article information

DOI

https://doi.org/10.1039/C7RA04735E

Article type

Review Article

Submitted

27 Apr 2017

Accepted

08 Jun 2017

First published

23 Jun 2017

This article is Open Access

Download Citation

RSC Adv., 2017,7, 32164-32184

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