Recent advances in nanomaterial-based synergistic combination cancer immunotherapy (original) (raw)
* Corresponding authors
a Cancer Centre, Faculty of Health Sciences, University of Macau, Macau SAR 999078, China
E-mail: yldai@um.edu.mo
b Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR 999078, China
c Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892, USA
E-mail: shawn.chen@nih.gov
Abstract
In recent years, conventional treatments including surgery, chemotherapy and radiotherapy have been the main approaches in tumour therapy. Cancer immunotherapy is a new therapeutic modality to fight cancer by harnessing the power of patients’ own immune system. Ongoing research related to these therapies has demonstrated their advantages and intrinsic limitations. Nanomaterial-based platforms are utilized in these emerging fields. In particular, a combination of other treatment methods with cancer immunotherapy to achieve precision medicine and prevent recurrence and metastasis, could improve patients’ outcome. The combined multiple treatments have superior efficacy to any monotherapy alone in producing improved anti-cancer activity. Therefore, it's necessary to summarise research advances in nanomaterial-based combination cancer immunotherapy contributing to clinical transformation. This review is based on the principles of cancer immunotherapy and the combined treatment design reflected by advances in materials science, including the structures of nanoplatforms and their underlying mechanisms towards cancer. The ultimate goals are to stimulate the design of better strategies for versatile use in the future based on biomaterial engineering methods to enhance the efficacy of combined cancer treatments, and to provide new ideas for the prospects of a synergistic cancer combination immunotherapy for clinical application transformation.
You have access to this article
Please wait while we load your content... Something went wrong. Try again?
Article information
DOI
https://doi.org/10.1039/C8CS00896E
Article type
Review Article
Submitted
26 Jan 2019
First published
05 Jun 2019
Download Citation
Chem. Soc. Rev., 2019,48, 3771-3810
Permissions
Recent advances in nanomaterial-based synergistic combination cancer immunotherapy
W. Sang, Z. Zhang, Y. Dai and X. Chen,Chem. Soc. Rev., 2019, 48, 3771DOI: 10.1039/C8CS00896E
To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.
If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.
If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.
Read more about how to correctly acknowledge RSC content.