A medical adhesive used in a wet environment by blending tannic acid and silk fibroin (original) (raw)
* Corresponding authors
a Department of Biomedical Engineering, School of Materials Science and Engineering, South China University of Technology, Guangzhou, People's Republic of China
b National Engineering Research Center for Tissue Restoration and Reconstruction (NERC-TRR), South China University of Technology, Guangzhou, People's Republic of China
c Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, Guangzhou 510006, P. R. China
d Key Laboratory of Biomedical Engineering of Guangdong Province, South China University of Technology, Guangzhou, China
e Innovation Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, P. R. China
f School of Medicine, South China University of Technology, Guangzhou, People's Republic of China
E-mail: mcqtli@scut.edu.cn, caoxd@scut.edu.cn
Abstract
A multifunctional and effective medical adhesive with a combination of high toughness and superior adhesion is highly desired in biomedical fields. However, clinical application of medical adhesives is still limited due to their weak adhesion to wet tissue. In this study, a novel medical adhesive called TASK composed of tannic acid (TA) and silk fibroin (SF) based on polyphenol-gel systems was developed. TASK powder was prepared by a simple physical mixture of pyrogallol-rich tannic acid and silk fibroin in aqueous solution and further freeze drying, which was stable and convenient for sterilization before clinical application. The TASK composite gel was formed by just adding water to the TASK powder. TASK showed improved wet-adhesive properties and stability; its adhesion strength after 5 h in water reached 180.9 ± 27.4 kPa. ATR-FTIR results indicated that the plentiful phenolic hydroxyl groups in TA allowed TASK to maintain adhesion to tissue in a wet environment. Furthermore, no chemical modification or covalent cross-linking was required for this wet-adhesive TASK which may facilitate its clinical application.
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Article information
DOI
https://doi.org/10.1039/D0BM00322K
Article type
Paper
Submitted
27 Feb 2020
Accepted
17 Mar 2020
First published
19 Mar 2020
Download Citation
Biomater. Sci., 2020,8, 2694-2701
Permissions
A medical adhesive used in a wet environment by blending tannic acid and silk fibroin
X. Gao, Q. Dai, L. Yao, H. Dong, Q. Li and X. Cao,Biomater. Sci., 2020, 8, 2694DOI: 10.1039/D0BM00322K
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