Nanomedicine-based tumor photothermal therapy synergized immunotherapy (original) (raw)
* Corresponding authors
a The Sixth Affiliated Hospital, Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, P. R. China
E-mail: bin.yang@gzhmu.edu.cn
b Guangdong Provincial Education Department Key Laboratory of Nano-Immunoregulation Tumor Microenvironment, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510220, P. R. China
c State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Medical University, Guangzhou 510120, P. R. China
Abstract
The emerging anti-tumor immunotherapy has made significant progress in clinical application. However, single immunotherapy is not effective for all anti-tumor treatments, owing to the low objective response rate and the risk of immune-related side effects. Meanwhile, photothermal therapy (PTT) has attracted significant attention because of its non-invasiveness, spatiotemporal controllability and small side effects. Combining PTT with immunotherapy overcomes the issue that single photothermal therapy cannot eradicate tumors with metastasis and recurrence. However, it improves the therapeutic effect of immunotherapy, as the photothermal therapy usually promotes release of tumor-related antigens, triggers immune response by the immunogenic cell death (ICD), thereby, endowing unique synergistic mechanisms for cancer therapy. This review summarizes recent research advances in utilizing nanomedicines for PTT in combination with immunotherapy to improve the outcome of cancer treatment. The strategies include immunogenic cell death, immune agonists and cancer vaccines, immune checkpoint blockades and tumor specific monoclonal antibodies, and small-molecule immune inhibitors. The combination of synergized PTT-immunotherapy with other therapeutic strategies is also discussed.
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Article information
DOI
https://doi.org/10.1039/D0BM01158D
Article type
Review Article
Submitted
13 Jul 2020
Accepted
19 Aug 2020
First published
20 Aug 2020
Download Citation
Biomater. Sci., 2020,8, 5241-5259
Permissions
Nanomedicine-based tumor photothermal therapy synergized immunotherapy
T. Shang, X. Yu, S. Han and B. Yang,Biomater. Sci., 2020, 8, 5241DOI: 10.1039/D0BM01158D
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