Photoactivated release of membrane impermeant sulfonates inside cells (original) (raw)
* Corresponding authors
a School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK
E-mail: richard.hartley@glasgow.ac.uk
b Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK
c MRC Mitochondrial Biology Unit, Hills Road, University of Cambridge, UK
Abstract
Photouncaging delivers compounds with high spatial and temporal control to induce or inhibit biological processes but the released compounds may diffuse out. We here demonstrate that sulfonate anions can be photocaged so that a membrane impermeable compound can enter cells, be uncaged by photoirradiation and trapped within the cell.
This article is Open Access
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Article information
DOI
https://doi.org/10.1039/D0CC07713E
Article type
Communication
Submitted
24 Nov 2020
Accepted
09 Mar 2021
First published
12 Mar 2021
This article is Open Access
Download Citation
Chem. Commun., 2021,57, 3917-3920
Permissions
Photoactivated release of membrane impermeant sulfonates inside cells
S. T. Caldwell, S. N. O'Byrne, C. Wilson, F. Cvetko, M. P. Murphy, J. G. McCarron and R. C. Hartley,Chem. Commun., 2021, 57, 3917DOI: 10.1039/D0CC07713E
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