A redox-sensitive core-crosslinked nanosystem combined with ultrasound for enhanced deep penetration of nanodiamonds into tumors (original) (raw)
* Corresponding authors
a State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, China
E-mail: 102733@cqmu.edu.cn, zengdp@cqmu.edu.cn, sajinbai@cqmu.edu.cn
b Chongqing Key Laboratory of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, China
Abstract
Nanodiamonds (NDs) as drug delivery vehicles are of great significance in anticancer therapy through enhancing drug retention. However, the major barrier to clinical application of NDs is insufficient tumor penetration owing to their strong aggregation and low passive penetration efficiency. Herein, the core-crosslinked pullulan carrier, assembled using the visible light-induced diselenide (Se–Se) bond crosslinking method for encapsulating nanodiamonds-doxorubicin (NDX), is proposed to improve monodispersity. Furthermore, the core-crosslinked diselenide bond provides the nanosystem with redox-responsive capability and improved structural stability in a physiological environment, which prevents premature drug leakage and achieves tumor site-specific controlled release. What's more, ultrasound (US) is utilized to promote nanosystem intratumoral penetration via enlarged tumor vascular endothelium cell gaps. As expected, the nanosystem combined with ultrasound can enhance anti-tumor efficacy with deep penetration and excellent retention performance in a HepG2 xenograft mouse model. This study highlights the ability of the integrated therapeutic paradigm to overcome the limitation of nanodiamonds and the potential for further application in cancer therapy.
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Article information
DOI
https://doi.org/10.1039/D0RA01776K
Article type
Paper
Submitted
24 Feb 2020
Accepted
22 Mar 2020
First published
17 Apr 2020
This article is Open Access
Download Citation
RSC Adv., 2020,10, 15252-15263
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A redox-sensitive core-crosslinked nanosystem combined with ultrasound for enhanced deep penetration of nanodiamonds into tumors
M. Li, Q. Li, W. Hou, J. Zhang, H. Ye, H. Li, D. Zeng and J. Bai,RSC Adv., 2020, 10, 15252DOI: 10.1039/D0RA01776K
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