Biodegradable pH-responsive amorphous calcium carbonate nanoparticles as immunoadjuvants for multimodal imaging and enhanced photoimmunotherapy (original) (raw)
* Corresponding authors
a Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, P. R. China
E-mail: songjun@szu.edu.cn, jlqu@szu.edu.cn
b Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, Oklahoma 73019, USA
E-mail: Wei-R-Chen@ou.edu
c Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
Abstract
Development of bioresponsive theranostic nanoparticles to enhance cancer diagnostics and control cancer metastasis is highly desirable. In this study, we developed such a bioresponsive theranostic nanoparticle for synergistic photoimmunotherapy. In particular, these nanoparticles were constructed by embedding indocyanine green (ICG) into Mn2+-doped amorphous calcium carbonate (ACC(Mn)) nanoparticles, followed by loading of the Toll-like-receptor-7 agonist imiquimod (IMQ). The IMQ@ACC(Mn)–ICG/PEG nanoparticles respond to the acidic pH of the tumor microenvironment (TME) and co-deliver ICG and IMQ into the tumor. Selective phototherapy was achieved upon activation using a near-infrared laser. In the presence of IMQ and arising from phototherapeutically treated tumor cells, tumor-associated antigens give rise to a strong antitumor immune response. Reversal of the immunosuppressive TME via H+ scavenging of the tumor through ACC nanoparticles effectively inhibits tumor metastases. Moreover, the combination of ICG and Mn2+ also serves as an advanced contrast agent for cancer multimode imaging. Overall, these bioresponsive nanoparticles provide a promising approach for cancer theranostics with promising potential for future clinical translation.
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Article information
DOI
https://doi.org/10.1039/D0TB01453B
Article type
Paper
Submitted
08 Jun 2020
Accepted
27 Jul 2020
First published
07 Aug 2020
Download Citation
J. Mater. Chem. B, 2020,8, 8261-8270
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Biodegradable pH-responsive amorphous calcium carbonate nanoparticles as immunoadjuvants for multimodal imaging and enhanced photoimmunotherapy
M. Wang, B. Zhou, L. Wang, F. Zhou, N. Smith, D. Saunders, R. A. Towner, J. Song, J. Qu and W. R. Chen,J. Mater. Chem. B, 2020, 8, 8261DOI: 10.1039/D0TB01453B
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