Terminal hydride formation in [FeFe] hydrogenase: understanding the role of the dithiolate bridgehead (original) (raw)

* Corresponding authors

a Department of Chemistry, University of Oxford, Inorganic Chemistry laboratory, South Parks Road, Oxford, UK

b School of Chemistry and Leicester Institute for Structural and Chemical Biology, University of Leicester, University Road, Leicester, UK
E-mail: prm28@leicester.ac.uk

c University of Nottingham, Faculty of Engineering, Coates Building, University Park, Nottingham, UK

d School of Life Sciences, University of Essex, Wivenhoe Park, Colchester, UK
E-mail: james.birrell@essex.ac.uk

Abstract

[FeFe]-hydrogenases are highly-active hydrogen-conversion biocatalysts using Earth-abundant metals in their active-site. Understanding their mechanism may enable design of catalysts for renewable energy storage. Here, observation of the crucial Fe-hydride-containing (Hhyd) intermediate in a PDT-variant of [FeFe]-hydrogenase reveals deeper insight into the role of the dithiolate bridgehead in the catalytic mechanism.

Graphical abstract: Terminal hydride formation in [FeFe] hydrogenase: understanding the role of the dithiolate bridgehead

This article is part of the themed collection:2025 Emerging Investigators

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Article information

DOI

https://doi.org/10.1039/D5CC00860C

Article type

Communication

Submitted

16 Feb 2025

Accepted

24 Mar 2025

First published

24 Mar 2025

This article is Open Access

Download Citation

Chem. Commun., 2025,61, 6178-6181

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