Markers to measure immunomodulation in human nutrition intervention studies | British Journal of Nutrition | Cambridge Core (original) (raw)

References

Albert, MA & Ridker, PM (1999) The role of C-reactive protein in cardiovascular disease risk. Curr Cardiol Rep 1, 99–104.CrossRefGoogle ScholarPubMed

Allsopp, CEM, Nicholls, SJ & Langhorne, J (1998) A flow cytometric method to assess antigen-specific proliferative responses of different subpopulations of fresh and cryopreserved human peripheral blood mononuclear cells. J Immunol Methods 214, 175–186.CrossRefGoogle ScholarPubMed

Ananworanich, J & Shearer, WT (2002) Delayed-type hypersensitivity skin testing.In Manual of Clinical Laboratory Immunology 6th ed. 212–219Rose, NR, Hamilton, B, Detrick, B, editors]. Washington, DC ASM PressGoogle Scholar

Arreaza, EE, Gibbons, JJ, Sisking, GW & Weksler, ME (1993) Lower antibody response to tetanus toxoid associated with higher auto-anti-idiotype antibody in old compared to young humans. Clin Exp Immunol 92, 169–176.CrossRefGoogle Scholar

Azim, T, Islam, LN, Sarker, MS, Ahmad, SM, Hamadani, JD, Faruque, SM & Salam, MA (2000) Immune response of Bangladeshi children with acute diarrhea who subsequently have persistent diarrhea. J Pediatr Gastroenterol Nutr 31, 528–535.Google ScholarPubMed

Aziz, M, Akhtar, S & Malik, A (1998) Evaluation of cell-mediated immunity and circulating immune complexes as prognostic indicators in cancer patients. Cancer Detect Prev 22, 87–99.CrossRefGoogle ScholarPubMed

Beery, TA (2003) Sex differences in infection and sepsis. Crit Care Nurs Clin North Am 15, 55–62.CrossRefGoogle Scholar

Berk, LS, Ton, SA, Nieman, DC & Eby, EC (1986) The suppressive effect of stress from acute exhaustive exercise on T-lymphocyte helper/suppressor ratio in athletes and non-athletes. Med Sci Sports Exerc 18, 706–710.CrossRefGoogle Scholar

Bienvenu, J, Monneret, G, Fabien, N & Revillard, JP (2000) The clinical usefulness of the measurement of cytokines. Clin Chem Lab Med 38, 267–285.CrossRefGoogle ScholarPubMed

Blannin, AK, Chatwin, LJ, Cave, R & Gleeson, M (1996) Effects of submaximal cycling and long-term endurance training on neutrophil phagocytic activity in middle-aged men. Br J, SportsM, ed 30, 125–129.CrossRefGoogle ScholarPubMed

Blatt, SP, Hendrix, CW, Butzin, CA, Freeman, TM, Ward, WW, Hensley, RE, Melcher, GP, Donovan, DJ & Boswell, RN (1993) Delayed-type hypersensitivity skin testing predicts progression to AIDS in HIV-infected patients. Ann Intern Med 119, 177–184.CrossRefGoogle ScholarPubMed

Bloemena, E, Roos, MT, Van Heijst, JL, Vossen, JM & Schellekens, PT (1989) Whole-blood lymphocyte cultures. J Immunol Methods 122, 161–167.CrossRefGoogle ScholarPubMed

Bogden, JD, Oleske, JM, Lavenhar, MA, Munves, EM, Kemp, FW, Bruening, KS, Holding, KJ, Denny, TN, Guarino, MA & Holland, BK (1990) Effects of one year supplementation with zinc and other micronutrients on cellular immunity in the elderly. J Am Coll Nutr 9, 214–225.CrossRefGoogle ScholarPubMed

Bogden, JD, Bendich, A, Kemp, FW, Bruening, KS, Skurnick, JH, Denny, T, Baker, H & Louria, DB (1994) Daily micronutrient supplements enhance delayed-hypersensitivity skin test responses in older people. Am J, Clin Nutr 60, 437–447.CrossRefGoogle ScholarPubMed

Bouman, A, Schipper, M, Heineman, MJ & Faas, MM (2004) Gender difference in the non-specific and specific immune response in humans. Am J, Reprod Immunol 52, 19–26.CrossRefGoogle ScholarPubMed

Bovee-Oudenhoven, IM, Lettink-Wissink, ML, Van Doesburg, W, Witteman, BJ, Van, DMeer, R (2003) Diarrhea caused by enterotoxigenic Escherichia coli infection of humans is inhibited by dietary calcium. Gastroenterology 125, 469–476.CrossRefGoogle ScholarPubMed

Brabin, L (2002) Interactions of the female hormone environment, susceptibility to viral infections, and disease progression. AIDS Patient Care STDS 16, 211–221.CrossRefGoogle ScholarPubMed

Bradley, JA, Ledingham, IM & Hamilton, DN (1981) Assessment of host resistance in critically ill surgical patients by the response to recall skin antigens. Intensive Care Med 7, 105–108.CrossRefGoogle ScholarPubMed

Broadbent, DE, Broadbent, MH, Phillpotts, RJ & Wallace, J (1984) Some further studies on the prediction of experimental colds in volunteers by psychological factors. J Psychosom Res 28, 511–523.CrossRefGoogle ScholarPubMed

Bruunsgaard, H, Hartkopp, A, Mohr, T, Konradsen, H, Heron, I, Mordhorst, CH & Pedersen, BK (1997) In vivo cell-mediated immunity and vaccination response following prolonged, intense exercise. Med Sci Sports Exerc 29, 1176–1181.CrossRefGoogle ScholarPubMed

Burdge, GC & Calder, PC (2005) Plasma cytokine response during the postprandial period: a potential causal process in vascular disease?. Br J Nutr 93, 3–9.CrossRefGoogle ScholarPubMed

Cakman, I, Rohwer, J, Schutz, RM, Kirchner, H & Rink, L (1996) Dysregulation between TH1 and TH2 cell sub-populations in the elderly. Mech Ageing Dev 87, 197–209.CrossRefGoogle Scholar

Calder, PC & Field, CJ (2002) Fatty acids, inflammation and immunity.In Nutrition and Immune Function pp.57 –92 [Calder, PC, Field, CJ, Gill, HS, editors]. OxfordCABI Publishing.CrossRefGoogle Scholar

Chandra, RK (1984) Excessive intake of zinc impairs immune responses. JAMA 52, 1443–1446.CrossRefGoogle Scholar

Chandra, RK (1991) 1990 McCollum Award Lecture: Nutrition and immunity: lessons from the past and new insights into the future. Am J, Clin Nutr 53, 1087–1101.CrossRefGoogle ScholarPubMed

Chandra, RK (1992) Effect of vitamin and trace-element supplementation on immune responses and infection in elderly subjects. Lancet 340, 1124–1127.CrossRefGoogle ScholarPubMed

Chang, L, Gusewitch, GA, Chritton, DB, Folz, JC, Lebeck, LK, Nehlsen-Cannarella, SL (1993) Rapid flow cytometric assay for the assessment of natural killer cell activity. J Immunol Methods 166, 45–54.CrossRefGoogle ScholarPubMed

Christou, NV, Meakins, JL, Gordon, J, Yee, J, Hassan-Zahraee, M, Nohr, CW, Shizgal, HM, MacLean, LD (1995) The delayed hypersensitivity response and host resistance in surgical patients: 20 years later. Ann Surg 222, 534–546.CrossRefGoogle ScholarPubMed

Cohen, S, Tyrrell, DA & Smith, AP (1991) Psychological stress and susceptibility to the common cold. N Eng J Med 325, 606–612.CrossRefGoogle ScholarPubMed

Cossarizza, A, Ortolani, C & Paganelli, R (1992) Age-related imbalance of virgin (CD45RA + ) and memory (CD45RO + ) cells between CD4 + and CD8 + T lymphocytes in humans: study from newborns to centenarians. J Immunol Res 4, 117–126.Google Scholar

Cross, NA, Shetty, G, Nordstrom, JW, Davis, CA & Kramer, TR (1998) Effects of mixed-carotenoid supplementation on plasma carotene concentrations and T lymphocyte immunocompetence in elderly black women. FASEB J 12 A857 AbstrGoogle Scholar

Cummings, JH, Antoine, J-M & Aspiroz, F (2004) PASSCLAIM – Gut health and immunity. Eur J Nutr 43 Suppl. 2 118–173CrossRefGoogle ScholarPubMed

Curotto de Lafaille, MA & Lafaille, JJ (2002) CD4 (+) regulatory T cells in autoimmunity and allergy. Curr Opin Immunol 14, 771–778.CrossRefGoogle ScholarPubMed

Dandona, P, Aljada, A & Bandyopadhyay, A (2004) Inflammation: the link between insulin resistance, obesity and diabetes. Trends Immunol 25, 4–7.CrossRefGoogle ScholarPubMed

Decker, T, Lohmann-Matthes, ML (1988) A quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor necrosis factor (TNF) activity. J Immunol Methods 115, 61–69.CrossRefGoogle ScholarPubMed

Dean, PA & Elson, CD (1997) Immunology.In Surgery of the Colon and Rectum.pp. 57 [Nicholls, RJ, Dozois, RR, editors]. New York: Churchill Livingstone.Google Scholar

Delacroix, DL, Dive, C, Rambaud, JC & Vaerman, JP (1982) IgA subclasses in various secretions and in serum. Immunology 47, 383–385.Google ScholarPubMed

Elsasser-Beile, Uvon Kleist, S & Gallati, H (1991) Evaluation of a test system for measuring cytokine production in human whole blood cell cultures. J Immunol Methods 139, 191–195.CrossRefGoogle ScholarPubMed

Faas, M, Bouman, A, Moesa, H, Heineman, MJ, de Leij, L (2000) Schuiling G The immune response during the luteal phase of the ovarian cycle: a TH2-type response. Fertil Steril 74, 1008–1013.CrossRefGoogle ScholarPubMed

Fietta, A, Merlini, C, Dos, SC, Rovida, S & Grassi, C (1994) Influence of aging on some specific and nonspecific mechanisms of the host defense system in 146 healthy subjects. Gerontology 40, 237–245.CrossRefGoogle ScholarPubMed

Fritscher-Ravens, A & Swain, CP (2002) The wireless capsule: new light in the darkness. Dig Dis 20 Suppl. 2 127–133.CrossRefGoogle ScholarPubMed

Fujiwara, S, Akiyama, M, Yamakido, M, Seyama, T, Kobuke, K, Hakoda, M, Kyoizumi, S & Jones, SL (1986) Cryopreservation of human lymphocytes for assessment of lymphocyte subsets and natural killer cytotoxicity. J Immunol Methods 90, 265–273.Google ScholarPubMed

Fuller, CJ, Faulkner, H, Bendich, A, Parker, RS & Roe, DA (1992) Effect of β-carotene supplementation on photosuppression of delayed-type hypersensitivity in normal young men. Am J Clin Nutr 56, 684–690.CrossRefGoogle ScholarPubMed

Gaines, H, Andersson, L & Biberfeld, G (1996) A new method for measuring lymphoproliferation at the single-cell level in whole blood cultures by flow cytometry. J Immunol Methods 195, 63–72.CrossRefGoogle ScholarPubMed

Gannon, GA, Rhind, S, Shek, PN & Shephard, RJ (2002) Naïve and memory T cell subsets are differentially mobilized during physical stress. Int J Sports Med 23, 223–229.CrossRefGoogle ScholarPubMed

Gardner, EM & Murasko, DM (2002) Age-related changes in type 1 and type 2 cytokine production in humans. Biogerontology 3, 271–290.CrossRefGoogle ScholarPubMed

Gill, HS & Cross, ML (2002) Probiotics and immune function. In Nutrition and Immune Function, pp. 251–272 [Calder, PC, Fields, CJ and Gill, HS, editors]. Oxford: CABI Publishing.CrossRefGoogle Scholar

Girardin, SE & Philpott, DJ (2004) Mini-review: the role of peptidoglycan recognition in innate immunity. Eur J Immmunol 34, 1777–1782.CrossRefGoogle ScholarPubMed

Gleeson, M (2000) Mucosal immune responses and risk of respiratory illness in elite athletes. Exerc Immunol Rev 6, 5–42.Google ScholarPubMed

Gleeson, M & Bishop, NC (1999) Immunology. In Basic and Applied Sciences for Sports Medicine, pp. 199–236 [Maughan, RJ, editor]. Oxford: Butterworth Heinemann.Google Scholar

Gordin, FM, Hartigan, PM, Klimas, NG, Zolla-Pazner, SB, Simberkoff, MS & Hamilton, JD (1994) Delayed-type hypersensitivity skin tests are an independent predictor of human immunodeficiency virus disease progression. Department of Veterans Affairs Cooperative Study Group. J Infect Dis 169, 893–897.CrossRefGoogle ScholarPubMed

Graat, JM, Schouten, EG & Kok, FJ (2002) Effect of daily vitamin E and multivitamin-mineral supplementation on acute respiratory tract infections in elderly persons: a randomized control trial. JAMA 288, 715–721.CrossRefGoogle Scholar

Hamrick, N, Cohen, S & Rodriguez, MS (2002) Being popular can be healthy or unhealthy: stress, social network diversity, and incidence of upper respiratory tract infection. Health Psychol 21, 294–298.CrossRefGoogle ScholarPubMed

Hayek, GM, Mura, C, Wu, D, Beharka, AA, Han, SN, Paulson, E, Hwang, D & Meydani, SN (1997) Enhanced expression of inducible cyclooxygenase with age in murine macrophages. J Immunol 159, 1445–1451.CrossRefGoogle ScholarPubMed

Heath, GW, Ford, ES, Craven, TE, Macera, CA, Jackson, KL & Pate, RR (1991) Exercise and the incidence of upper respiratory tract infections. Med Sci Sports Exerc 23, 152–157.CrossRefGoogle ScholarPubMed

Herraiz, LA, Hsieh, WC, Parker, RS, Swanson, JE, Bendich, A & Roe, DA (1998) Effect of UV exposure and β-carotene supplementation on delayed-type hypersensitivity response in healthy older men. J Am Coll Nutr 17, 617–624.CrossRefGoogle ScholarPubMed

Hofmann, B, Bygbjerg, I, Dickmeiss, E, Faber, V, Frederiksen, B, Gaub, J, Gerstoft, J, Jakobsen, BK, Jakobsen, KD & Lindhardt, BO (1989) Prognostic value of immunologic abnormalities and HIV antigenemia in asymptomatic HIV-infected individuals: proposal of immunologic staging. Scand J Infect Dis 21, 633–643.CrossRefGoogle ScholarPubMed

Hutchinson, P, Divola, LA & Holdsworth, SR (1999) Mitogen-induced T-cell CD69 expression is a less sensitive measure of T-cell function than [3H]-thymidine uptake. Cytometry 38, 244–249.3.0.CO;2-M>CrossRefGoogle ScholarPubMed

Imai, K, Matsuyama, S, Miyake, S, Suga, K & Nakachi, K (2000) Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence: an 11-year follow-up study of a general population. Lancet 356, 1795–1799.CrossRefGoogle ScholarPubMed

Isaacs, D, Webster, ADB & Valman, HB (1984) Immunoglobulin levels and function in preschool children with recurrent respiratory infections. Clin Exp Immunol 58, 335–340.Google ScholarPubMed

Janeway, CA, Travers, P, Walport, M & Shlomchik, M (2005) Immunobiology, 6th ed. London: Garland Publishing.Google Scholar

Jemmott, JB, Borysenko, JZ, Borysenko, M, McClelland, DC, Chapman, R, Meyer, D & Benson, H (1983) Academic stress, power motivation, and decrease in secretion rate of salivary secretory immunoglobulin A. Lancet 1, 1400–1402.CrossRefGoogle ScholarPubMed

Jewett, MA, Gupta, S, Hansen, JA, Cunningham-Rundles, S, Siegal, FP, Good, RA & Dupont, B (1976) The use of cryopreserved lymphocytes for longitudinal studies of immune function and enumeration of subpopulations. Clin Exp Immunol 25, 449–454.Google ScholarPubMed

Keil, D, Luebke, RW & Pruett, SB (2001) Quantifying the relationship between multiple immunological parameters and host resistance: probing the limits of reductionism. J Immunol 167, 4543–4552.CrossRefGoogle ScholarPubMed

Komatsu, M, Kobayashi, D, Saito, K, Furuya, D, Yagihashi, A, Araake, H, Tsuji, N, Sakamaki, S, Niitsu, Y & Watanabe, N (2001) Tumor necrosis factor-a in serum of patients with inflammatory bowel disease as measured by a highly sensitive immuno-PCR. Clin Chem 47, 1297–1301.CrossRefGoogle Scholar

Konjevic, G, Jurisic, V & Spuzic, I (1997) Corrections to the original lactate dehydrogenase (LDH) release assay for the evaluation of NK cell cytotoxicity. J Immunol Methods 200, 199–201.CrossRefGoogle Scholar

Kramer, TR & Burri, BJ (1997) Modulated mitogenic proliferative responsiveness of lymphocytes in whole-blood cultures after a low-carotene diet and mixed-carotenoid supplementation in women. Am J Clin Nutr 65, 871–875.CrossRefGoogle ScholarPubMed

Kruse, N & Rieckmann, P (2002) Molecular analysis of cytokines and cytokine receptors. In Manual of Clinical Laboratory Immunology, 6th ed. 347–356 [Rose, NR, Hamilton, B and Detrick, B, editors]. Washington, DC: ASM Press.Google Scholar

Kuritzkes, DR (2000) Neutropenia, neutrophil dysfunction, and bacterial infection in patients with human immunodeficiency virus disease: the role of granulocyte colony-stimulating factor. Clin Infect Dis 30, 256–260.CrossRefGoogle ScholarPubMed

Lancaster, GL, Halson, SL, Khan, Q, Drysdale, P, Jeukendrup, AE, Drayson, MT & Gleeson, M (2003 a) Effect of acute exhaustive exercise and a 6-day period of intensified training on immune function in cyclists. J Physiol 548, O96.Google Scholar

Lancaster, GL, Halson, SL, Khan, Q, Drysdale, P, Jeukendrup, AE, Drayson, MT & Gleeson, M (2003 b) Effect of exhaustive exercise and intensified training on human T-lymphocyte CD45RO expression. J Physiol 548, O97.Google Scholar

Lancaster, GL, Khan, Q, Drysdale, P, Jeukendrup, AE, Drayson, MT & Gleeson, M (2003 c) The effect of exercise on the expression and function of human monocyte toll-like receptors. J Physiol 555, C112.Google Scholar

Lehmann, AK, Sornes, S & Halstensen, A (2000) Phagocytosis: measurement by flow cytometry. J Immunol Methods 243, 229–242.CrossRefGoogle ScholarPubMed

Leroux-Roels, G, Van Hecke, E, Michielsen, W, Voet, P, Hauser, P & Petre, J (1994) Correlation between in vivo humoral and in vitro cellular immune responses following immunization with hepatitis B surface antigen (HBsAg) vaccines. Vaccine 12, 812–818.CrossRefGoogle ScholarPubMed

Lesourd, B (2000) Undernutrition: a factor of accelerated ageing in healthy and diseased aged persons. In Handbook of Nutrition in the Aged Persons, pp. 145–158 [Watson, RR, editor]. New York: CRC Press.CrossRefGoogle Scholar

Lesourd, BM, Wang, A & Moulias, R (1985) Serial delayed cutaneous hypersensitivity skin testing with multiple recall antigens in healthy volunteers: booster effect study. Ann Allergy 55, 729–735.Google ScholarPubMed

Lesourd, B, Raynaud-Simon, A & Mazari, L (2002) Nutrition and ageing of the immune system. In Nutrition and Immune Function, pp. 357–374 [Calder, PC, Field, CJ and Gill, HS, editors]. Oxford: CABI Publishing.CrossRefGoogle Scholar

Levy, SM, Herberman, RB, Lee, J, Whiteside, T, Beadle, M, Heiden, L & Simons, A (1991) Persistently low natural killer cell activity, age, and environmental stress as predictors of infectious morbidity. Nat Immun Cell Growth Regul 10, 289–307.Google ScholarPubMed

Liebmann, PM, Reibnegger, G, Lehofer, M, Moser, M, Purstner, P, Mangge, H & Schauenstein, K (1998) Circadian rhythm of the soluble p75 tumor necrosis factor (sTNF-R75) receptor in humans – a possible explanation for the circadian kinetics of TNF-α effects. Int Immunol 10, 1393–1396.CrossRefGoogle Scholar

Liew, FY (2002) T(H)1 and T(H)2 cells: a historical perspective. Nature Rev Immunol 2, 55–60.CrossRefGoogle Scholar

Ligthart, GJ, Corberand, JX, Fournier, C, Galanaud, P, Hijmans, W, Kennes, B, Muller-Hermelink, HK & Steinmann, GG (1984) Admission criteria for immunogerontological studies in man: the SENIEUR protocol. Mech Ageing Dev 28, 47–55.CrossRefGoogle ScholarPubMed

Lord, JM, Butcher, S, Killampali, V, Lascelles, D & Salmon, M (2001) Neutrophil ageing and immunesenescence. Mech Ageing Dev 122, 1521–1535.CrossRefGoogle ScholarPubMed

Lyons, AB (2000) Analysing cell division in vivo and in vitro using flow cytometric measurement of CFSE dye dilution. J Immunol Methods 243, 147–154.CrossRefGoogle ScholarPubMed

Mackinnon, LT (1999) Advances in Exercise and Immunology Champaign, IL Human KineticsGoogle Scholar

MacLean, LD (1988) Delayed type hypersensitivity testing in surgical patients Surg Gynecol Obstet 166, 285–293.Google ScholarPubMed

MacLennan, ICM & Drayson, MT (1999) Normal lymphocytes and non-neoplastic lymphocyte disorders. In Postgraduate Haematology 4th ed. 296 – 298 [Hoffbrand, AV, Lewis, SM, Tuddenham, EGDOxford: Butterworth Heinemann.Google Scholar

Maloy, KJ, Salaun, L, Cahill, R, Dougan, G, Saunders, NJ & Powrie, F (2003) CD4 + CD25 + T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms. J Exp Med 197, 111–119.CrossRefGoogle ScholarPubMed

Mann, DR, Akinbami, MA, Gould, KG & Ansari, AA (2000) Seasonal variation in cytokine expression and cell-mediated immunity in male rhesus monkeys. Cell Immunol 200, 105–115.CrossRefGoogle ScholarPubMed

Marrie, TJ, Johnson, S & Durant, H (1988) Cell-mediated immunity of healthy adult Nova Scotians in various age groups compared with nursing home and hospitalized senior citizens. J Allergy Clin Immunol 81, 836–843.CrossRefGoogle ScholarPubMed

Martinon, F, Rabian, C, Loiseau, P, Ternynck, TAvrameas, S & Colombani, J (1987) In vitro proliferation of human lymphocytes measured by an enzyme immunoassay using an anti-5-bromo-2-deoxyuridine monoclonal antibody. J Clin Lab Immunol 23, 153–159.Google ScholarPubMed

Matthews, CE, Ockene, IS, Freedson, PS, Rosal, MC, Merriam, PA & Hebert, JR (2002) Moderate to vigorous physical activity and the risk of upper-respiratory tract infection. Med Sci Sports Exerc 34, 1242–1248.CrossRefGoogle ScholarPubMed

Mazari, L & Lesourd, B (1998) Nutritional influence on immune response in healthy aged persons. Mech Ageing Dev 100, 17–32.Google Scholar

Messele, T, Roos, MT, Hamann, D, Koot, M, Fontanet, AL, Miedema, F, Schellekens, PT & Rinke de Wit, TF (2000) Nonradioactive techniques for measurement of in vitro T-cell proliferation: alternatives to the [3 H]thymidine incorporation assay. Clin Diagn Lab Immunol 7, 687–692.CrossRefGoogle Scholar

Meyaard, L, Kuiper, H, Otto, SA, Wolthers, KC, Van Lier, RA & Miedema, F (1995) Evidence for intact costimulation via CD28 and CD27 molecules in hyporesponsive T cells from human immunodeficiency virus-infected individuals. Eur J Immunol 25, 232–237.CrossRefGoogle ScholarPubMed

Meydani, SN, Barklund, MP, Liu, S, Meydani, M, Miller, RA, Cannon, JG, Morrow, FD, Rocklin, R & Blumberg, JB (1990) Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects. Am J, Clin Nutr 52, 557–563.CrossRefGoogle ScholarPubMed

Meydani, SN, Meydani, M, Blumberg, JB, Lekal, S, Siber, G, Loszewski, R, Thompson, C, Pedrosa, C, Diamond, RD & Stollar, BD (1997) Vitamin E supplementation and in vivo immune responses in healthy elderly individuals. JAMA 277, 1380–1386.CrossRefGoogle Scholar

Moynihan, JA, Callahan, TA, Kelley, SP & Campbell, LM (1998) Adrenal hormone modulation of type 1 and type 2 cytokine production by spleen cells: dexamethasone and dehydroepiandrosterone suppress interleukin-2, interleukin-4, and interferon-gamma production in vitro. Cell Immunol 184, 58–64.CrossRefGoogle ScholarPubMed

Murasko, DM, Weiner, P & Kaye, D, (1987) Decline in mitogen induced proliferation of lymphocytes with increasing age. Clin Exp Immunol 70, 440–448.Google ScholarPubMed

Mylonaki, M, Fritscher-Ravens, A & Swain, P, (2003) Wireless capsule endoscopy: a comparison with push enteroscopy in patiens with gastroscopy and colonoscopy negative gastrointestinal bleeding. Gut 52, 1122–1126.CrossRefGoogle Scholar

Myrianthefs, P, Karatzas, S, Venetsanou, K, Grouzi, E, Evagelopoulou, P, Boutzouka, E, Fildissis, G, Splilotopoulou, I & Baltopoulos, G (2003) Seasonal variation in whole blood cytokine production after LPS stimulation in normal individuals. Cytokine 24, 286–292.CrossRefGoogle ScholarPubMed

Nagao, F, Yabe, T, Xu, M, Yokoyama, K, Saito, K & Okumura, K (1996) Application of non-radioactive europium (Eu 3+ ) release assay to a measurement of human natural killer activity of healthy and patient populations. Immunol Invest 25, 507–518.CrossRefGoogle Scholar

Nieman, DC, Johansen, LM, Lee, JW & Arabatzis, K (1990) Infectious episodes in runners before and after the Los Angeles Marathon. J Sports Med Phys Fitness 30, 316–328.Google ScholarPubMed

Niess, AM, Dickhuth, H-H, Northoff, H & Fehrenbach, E (1999) Free radicals and oxidative stress in exercise – immunological aspects. Exerc Immunol Rev 5, 22–56.Google ScholarPubMed

Nisbet-Brown, ER, Lee, JW, Cheung, RK & Gelfand, EW (1987) Antigen-specific and -nonspecific mitogenic signals in the activation of human T cell clones. J Immunol 138, 3713–3719.CrossRefGoogle ScholarPubMed

Northoff, H, Berg, A & Weinstock, C (1998) Similarities and differences of the immune response to exercise and trauma: the IFN-γ concept. Can J Physiol Pharmacol 76, 497–504.CrossRefGoogle ScholarPubMed

O'Gorman, MRG (2002) Evaluation of phagocytic cell function. In Manual of Clinical Laboratory Immunology, 6th ed., pp. 265–273 [Rose, NR, Hamilton, B and Detrick, B, editors]. Washington, DC: ASM Press.Google Scholar

Ogata, K, An, E, Shioi, Y, Nakamura, K, Luo, S, Yokose, N, Minami, S & Dan, K (2001) Association between natural killer cell activity and infection in immunologically normal elderly people. Clin Exp Immunol 124, 392–397.CrossRefGoogle ScholarPubMed

Ouellette, AJ & Bevins, CL (2000) Development of innate immunity in the small intestine. In Development of the Gastrointestinal Tract, pp. 147–164 [Sanderson, IR and Walker, WA, editors]. Hamilton, BC: Decker.Google Scholar

Pallast, EG, Schouten, EGDe Waart, FG, Fonk, HC, Doekes, G, von Blomberg, BM & Kok, FJ (1999) Effect of 50- and 100-mg vitamin E supplements on cellular immune function in noninstitutionalized elderly persons. Am J Clin Nutr 69, 1273–1281.CrossRefGoogle ScholarPubMed

Pawelec, G, Barnett, Y & Forsey, R (2002) T cells and aging, January 2002 update. Front Biosci 1, 1056–1283.CrossRefGoogle Scholar

Pawelec, G, Akbar, A, Caruso, C, Effros, R, Grubeck-Loebenstein, B & Wikby, A (2004) Is immunosenescence infectious?. Trends Immunol 25, 406–410.CrossRefGoogle ScholarPubMed

Pedersen, BK & Bruunsgaard, H (1995) How physical exercise influences the establishment of infections. Sports Med 19, 393–400.CrossRefGoogle ScholarPubMed

Peters, EM & Bateman, ED (1983) Ultramarathon running and URTI: an epidemiological survey. S A Med J 64, 582–584.Google Scholar

Peters, EM, Goetzsche, JM, Grobbelaar, B & Noakes, TD (1993) Vitamin C supplementation reduces the incidence of post-race symptoms of upper respiratory tract infection in ultramarathon runners. Am J, Clin Nutr 57, 170–174.CrossRefGoogle Scholar

Peters, EM, Goetzsche, JM, Joseph, LE & Noakes, TD (1996) Vitamin C as effective as combinations of anti-oxidant nutrients in reducing symptoms of upper respiratory tract infections in ultramarathon runners. S A J Sports Med 11, 23–27.Google Scholar

Petersen, EW & Pedersen, BK (2002) Exercise and immune function Nutrition and Immune Function 347 – 355 [Calder, PC, Fields, CJ, Gill, HS], Oxford: CABI PublishingCrossRefGoogle Scholar

Provinciali, M, Di Stefano, G & Fabris, N (1992) Optimization of cytotoxic assay by target cell retention of the fluorescent dye carboxyfluorescein diacetate (CFDA) and comparison with conventional 51 Cr release assay. J Immunol Methods 155, 19–24.CrossRefGoogle Scholar

Remick, DG (2002) Protein analysis and bioassays of cytokines and cytokine receptors. In Manual of Clinical Laboratory Immunology, 6th ed., pp. 320–337 [Rose, NR, Hamilton, B and Detrick, B, editors]. Washington, DC: ASM Press.Google Scholar

Renshaw, M, Rockwell, J, Englemann, C, Gerwirtz, A, Katz, J & Sambhara, S (2002) Cutting edge: impaired toll-like receptor expression and function in aging. J Immunol 169, 4697–4701.CrossRefGoogle ScholarPubMed

Robson, PJ, Blannin, AK, Walsh, NP, Castell, LM & Gleeson, M (1999) Effects of exercise intensity, duration and recovery on in vitro neutrophil function in male athletes. Int J Sports Med 20, 128–135.Google ScholarPubMed

Roller, M, Rechkemmer, G & Watzl, B (2004) Prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis modulates intestinal immune functions in rats. J Nutr 134, 153–156.CrossRefGoogle ScholarPubMed

Ronsen, O, Pedersen, BK, Oritsland, TR & Bahr, RKjeldsen-Kragh, J (2001) Leukocyte counts and lymphocyte responsiveness associated with repeated bouts of strenuous endurance exercise. J Appl Physiol 91, 425–434.CrossRefGoogle ScholarPubMed

Samartin, S & Chandra, RK (2001) Obesity, overnutrition and the immune system. Nutr Rev 21, 243–262.Google Scholar

Sapolsky, RM, Krey, LC & McEwen, BS (1986) The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis. Endocr Rev 7, 284–301.CrossRefGoogle ScholarPubMed

Schellekens, PT, Roos, MT, De Wolf, F, Lange, JM & Miedema, F (1990) Low T-cell responsiveness to activation via CD3/TCR is a prognostic marker for acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus-1 (HIV-1)-infected men. J Clin Immunol 10, 121–127.CrossRefGoogle ScholarPubMed

Schnare, M, Barton, GM, Holt, AC, Takeda, K, Akira, S & Medzhitov, R (2001) Toll-like receptors control activation of adaptive immune responses. Nat Immunol 2, 947–950.CrossRefGoogle ScholarPubMed

Scrimshaw, NS & SanGiovanni, JP (1997) Synergism of nutrition, infection and immunity: an overview. Am J Clin Nutr 66, 464S–477S.CrossRefGoogle Scholar

Shephard, RJ (1997) Physical Activity, Training and the Immune Response Carmel, IN: Cooper.Google Scholar

Shephard, RJ & Shek, PN (1999) Effects of exercise and training on natural killer cell counts and cytolytic activity: a meta-analysis. Sports Med 28, 177–195.CrossRefGoogle ScholarPubMed

Sleijffers, A, Garssen, J, de Gruijl, FR, Boland, GJ, Van Hattum, J, Van Vloten, WA & Van Loveren, H (2001) Influence of ultraviolet B exposure on immune responses following hepatitis B vaccination in human volunteers. J Invest Dermatol 117, 1144–1150.CrossRefGoogle ScholarPubMed

Smith, DS, Helzner, EC, Nuttall, CE Jr, Collins, M, Rofman, BA, Ginsberg, D, Goswick, CB & Magner, A (1989) Failure of zinc gluconate in treatment of upper respiratory tract infections. Antimicrob Agents Chemother 33, 646–648.CrossRefGoogle ScholarPubMed

Smith, JK, Chi, DS, Krish, G, Reynolds, S & Cambron, G (1990) Effect of exercise on complement activity. Ann Allergy 65, 304–310.Google ScholarPubMed

Spirer, Z, Roifman, CM & Branski, D (1993) Pediatric Immunology. Pediatric and Adolescent Medicine, vol. 3. Basel: Karger.Google Scholar

Starkie, RL, Rolland, J, Angus, DJ, Anderson, MJ & Febbraio, M (2001) Circulating monocytes are not the source of elevations in plasma IL-6 and TNF-α levels after prolonged running. Am J Physiol Cell Physiol 280, C769–C774.CrossRefGoogle Scholar

Steensberg, A, Van Hall, G, Osada, T, Sacchetti, M, Saltin, B & Pedersen, BK (2000) Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6. J Physiol 529, 237–242.CrossRefGoogle ScholarPubMed

Tacket, CO, Binion, SB, Bostwick, E, Losonsky, G, Roy, MJ & Edelman, R (1992) Efficacy of bovine milk immunoglobulin concentrate in preventing illness after Shigella flexneri challenge. Am J Trop Med Hyg 47, 276–283.CrossRefGoogle ScholarPubMed

Tollerud, DJ, Morris Brown, L, Clark, JW, Neuland, CY, Mann, DL, Pankiw-Trost, LK & Blattner, WA (1991) Cryopreservation and long-term liquid nitrogen storage of peripheral blood mononuclear cells for flow cytometry analysis: effects on subsets proportions and fluorescence intensity. J Clin Lab Anal 5, 255–261.Google ScholarPubMed

Touloumi, G, Pantazis, N, Karafoulidou, A, Mandalaki, T, Goedert, JJ, Kostrikis, LG & Hatzakis, A (2004) Changes in T cell receptor excision DNA circle (TREC) levels in HIV type 1-infected subjects pre- and post-highly active antiretroviral therapy. AIDS Res Hum Retroviruses 20, 47–54.CrossRefGoogle Scholar

Turner, RB & Cetnarowski, WE (2000) Effect of treatment with zinc gluconate or zinc acetate on experimental and natural colds. Clin Infect Dis 31, 1202–1208.CrossRefGoogle ScholarPubMed

Turner, RB, Riker, DK & Gangemi, JD (2000) Ineffectiveness of echinacea for prevention of experimental rhinovirus colds. Antimicrob Agents Chemother 44, 1708–1709.CrossRefGoogle ScholarPubMed

Van Loveren, H, Germolec, D, Koren, HS, Luster, MI, Nolan, C, Repetto, R, Smith, E, Vos, JG & Vogt, RF (1999) Report of the Bilthoven Symposium: Advancement of epidemiological studies in assessing the human health effects of immunotoxic agents in the environment and the workplace. Biomarkers 4, 135–157.CrossRefGoogle Scholar

Van Loveren, H, Van Amsterdam, JG, Vandebriel, RJ, Kimman, TG, Rumke, HC, Steerenberg, PS & Vos, JG (2001) Vaccine-induced antibody responses as parameters of the influence of endogenous and environmental factors. Environ Health Perspect 109, 757–764.CrossRefGoogle ScholarPubMed

Verde, TJ, Thomas, SG, Moore, RW, Shek, P & Shephard, RJ (1992) Immune responses and increased training of the elite athlete. J Appl Physiol 73, 1494–1499.CrossRefGoogle ScholarPubMed

Walrand, S, Moreau, K, Caldefie, F, Tridon, A, Chassagne, J, Portefaix, G, Cynober, L, Beaufrère, B, Vasson, M-P & Boirie, Y (2001) Specific and nonspecific immune responses to fasting and refeeding differ in young adult and elderly persons. Am J Clin Nutr 74, 670–678.CrossRefGoogle ScholarPubMed

Weksler, ME (1995) Immune senescence: deficiency or dysregulation? Nutr Rev 53, Suppl., S1–S7.Google ScholarPubMed

Westermann, J & Pabst, R (1990) Lymphocyte subsets in the blood: a diagnostic window on the lymphoid system? Immunol Today 11, 406–410.CrossRefGoogle Scholar

Whiteside, TL, Bryant, J, Day, R & Herberman, RB (1990) Natural killer cytotoxicity in the diagnosis of immune dysfunction: criteria for a reproducible assay. J Clin Lab Anal 4, 102–114.CrossRefGoogle ScholarPubMed

Wiedermann, U, Kundi, M, Vollmann, U, Kollaritsch, H, Ebner, C & Wiedermann, G (2000) Different HBs antibody versus lymphoproliferative responses after application of a monovalent (hepatitis B) or combined (hepatitis A+hepatitis B) vaccine. Int Arch Allergy Immunol 123, 349–353.CrossRefGoogle ScholarPubMed

Wolf, R (2004) Essential Pediatric Allergy, Asthma and Immunology. New York: McGraw-Hill.Google Scholar

Woods, J, Lu, Q, Ceddia, MA & Lowder, T (2000) Special feature for the Olympics: effects of exercise on the immune system: exercise-induced modulation of macrophage function. Immunol Cell Biol 78, 545–553.Google ScholarPubMed

Yaqoob, P, Newsholme, EA & Calder, PC (1999) Comparison of cytokine production in cultures of whole human blood and purified mononuclear cells. Cytokine 11, 600–605.CrossRefGoogle ScholarPubMed

Ye, P & Kirshner, DE (2002) Measuring emigration of human thymocytes by T-cell receptor excision circles. Crit Rev Immunol 22, 483–497.CrossRefGoogle ScholarPubMed

Zaman, K, Baqui, AH, Yunus, M, Sack, RB, Chowdhury, HR & Black, RE (1997) Malnutrition, cell-mediated immune deficiency and acute upper respiratory infections in rural Bangladeshi children. Acta Paediatr 86, 923–927.CrossRefGoogle ScholarPubMed

Zeidel, A, Beilin, B, Yardeni, I, Mayburd, E, Smirnov, G & Bessler, H (2002) Immune response in asymptomatic smokers. Acta Anaesthesiol Scand 46, 959–964.CrossRefGoogle ScholarPubMed