Tuberculosis and Chronic Hepatitis B Virus Infection in Africans and Variation in the Vitamin D Receptor Gene (original) (raw)

Journal Article

,

Wellcome Trust Centre For Human Genetics, University of Oxford

,

Oxford

, and

Department of Medicine, Imperial College School of Medicine, St. Mary's Hospital

,

London

,

United Kingdom

;

Medical Research Council Laboratories

,

Fajara, Banjul

,

The Gambia

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,

Wellcome Trust Centre For Human Genetics, University of Oxford

,

Oxford

, and

Department of Medicine, Imperial College School of Medicine, St. Mary's Hospital

,

London

,

United Kingdom

;

Medical Research Council Laboratories

,

Fajara, Banjul

,

The Gambia

Search for other works by this author on:

,

Wellcome Trust Centre For Human Genetics, University of Oxford

,

Oxford

, and

Department of Medicine, Imperial College School of Medicine, St. Mary's Hospital

,

London

,

United Kingdom

;

Medical Research Council Laboratories

,

Fajara, Banjul

,

The Gambia

Search for other works by this author on:

,

Wellcome Trust Centre For Human Genetics, University of Oxford

,

Oxford

, and

Department of Medicine, Imperial College School of Medicine, St. Mary's Hospital

,

London

,

United Kingdom

;

Medical Research Council Laboratories

,

Fajara, Banjul

,

The Gambia

Search for other works by this author on:

,

Wellcome Trust Centre For Human Genetics, University of Oxford

,

Oxford

, and

Department of Medicine, Imperial College School of Medicine, St. Mary's Hospital

,

London

,

United Kingdom

;

Medical Research Council Laboratories

,

Fajara, Banjul

,

The Gambia

Search for other works by this author on:

,

Wellcome Trust Centre For Human Genetics, University of Oxford

,

Oxford

, and

Department of Medicine, Imperial College School of Medicine, St. Mary's Hospital

,

London

,

United Kingdom

;

Medical Research Council Laboratories

,

Fajara, Banjul

,

The Gambia

Search for other works by this author on:

Wellcome Trust Centre For Human Genetics, University of Oxford

,

Oxford

, and

Department of Medicine, Imperial College School of Medicine, St. Mary's Hospital

,

London

,

United Kingdom

;

Medical Research Council Laboratories

,

Fajara, Banjul

,

The Gambia

Reprints or correspondence: Dr. A. V. S. Hill, Wellcome Trust Centre for Human Genetics, University of Oxford, Windmill Rd., Oxford OX3 7BN, UK (adrian.hill@well.ox.ac.uk).

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Received:

29 December 1997

Revision received:

29 October 1998

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R. Bellamy, C. Ruwende, T. Corrah, K. P. W. J. McAdam, M. Thursz, H. C. Whittle, A. V. S. Hill, Tuberculosis and Chronic Hepatitis B Virus Infection in Africans and Variation in the Vitamin D Receptor Gene, The Journal of Infectious Diseases, Volume 179, Issue 3, March 1999, Pages 721–724, https://doi.org/10.1086/314614
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Abstract

The active metabolite of vitamin D, 1,25 dihydroxyvitamin D3, is an important immunoregulatory hormone [1]. Its effects are exerted by interaction with the vitamin D receptor, which is present on human monocytes and activated T and B lymphocytes. Variation in the vitamin D receptor gene was typed in 2015 subjects from large case-control studies of three major infectious diseases: tuberculosis, malaria, and hepatitis B virus. Homozygotes for a polymorphism at codon 352 (genotype tt) were significantly underrepresented among those with tuberculosis (χ2 = 6.22, 1 df, P = .01) and persistent hepatitis B infection (χ2 = 6.25, 1 df, P = .01) but not in subjects with clinical malaria compared with the other genotypes. Therefore, this genetic variant, which predisposes to low bone mineral density in many populations, may confer resistance to certain infectious diseases.

© 1999 by the Infectious Diseases Society of America

Topic:

• exertion
• b-lymphocytes
• polymorphism
• bone mineral density
• hormones
• hepatitis b
• codon nucleotides
• communicable diseases
• genes
• genotype
• hepatitis b, chronic
• homozygote
• malaria
• monocytes
• vitamin d3 receptor
• tuberculosis
• genetics
• hepatitis b virus
• vitamin d
• persistence
• metabolites

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