Rapid Antiviral Effect of Inhaled Zanamivir in the Treatment of Naturally Occurring Influenza in Otherwise Healthy Adults (original) (raw)

Journal Article

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1

Infectious Disease Research Center, Centre Hospitalier Universitaire de Québec, and Division of Microbiology, Laval University

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Québec

Reprints or correspondence: Dr. Guy Boivin, Centre Hospitalier Universitaire de Québec, Pavillon CHUL, RC-709, 2705 Blvd. Laurier, Sainte-Foy, Québec, Canada G1V 4G2 (Guy.Boivin@crchul.ulaval.ca).

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1

Infectious Disease Research Center, Centre Hospitalier Universitaire de Québec, and Division of Microbiology, Laval University

,

Québec

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1

Infectious Disease Research Center, Centre Hospitalier Universitaire de Québec, and Division of Microbiology, Laval University

,

Québec

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2

Departments of Medicine, Medical Microbiology, Pharmacology, and Therapeutics, University of Manitoba

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Winnipeg

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3

Glaxo Wellcome

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Mississauga

,

Canada

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Infectious Disease Research Center, Centre Hospitalier Universitaire de Québec, and Division of Microbiology, Laval University

,

Québec

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Received:

24 September 1999

Revision received:

09 December 1999

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Guy Boivin, Nathalie Goyette, Isabelle Hardy, Fred Aoki, Anthony Wagner, Sylvie Trottier, Rapid Antiviral Effect of Inhaled Zanamivir in the Treatment of Naturally Occurring Influenza in Otherwise Healthy Adults, The Journal of Infectious Diseases, Volume 181, Issue 4, April 2000, Pages 1471–1474, https://doi.org/10.1086/315392
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Abstract

The antiviral and clinical effects of inhaled zanamivir (10 mg twice daily for 5 days, started within the first or second day of a flulike illness) were evaluated in a randomized, placebo-controlled trial during the 1997–1998 influenza season in Canada. Pharyngeal secretions were collected with swabs every 12 h during 6 days, and symptoms were self-evaluated twice daily during 14 days. After only 12 h of treatment (1 dose), median virus titers decreased by 1.0 log10 TCID50/mL in the zanamivir group (n = 17), compared with a 0.42-log10 increase in the placebo group (n = 10; P = .08). This was associated with a 4.5-day (47.4%) reduction in the median time to alleviation of all significant flu symptoms in the zanamivir recipients (P = .03 after adjusting for the initial virus titer and the time between onset of symptoms and treatment). Resistance to zanamivir was not detected in virus isolates by either phenotypic or genotypic assays.

© 2000 by the Infectious Diseases Society of America

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