Rhinoviruses Infect the Lower Airways (original) (raw)

Journal Article

,

University Medicine, Southampton General Hospital

,

Southampton

,

United Kingdom

Search for other works by this author on:

,

University Medicine, Southampton General Hospital

,

Southampton

,

United Kingdom

Search for other works by this author on:

,

University Medicine, Southampton General Hospital

,

Southampton

,

United Kingdom

Search for other works by this author on:

,

University Medicine, Southampton General Hospital

,

Southampton

,

United Kingdom

Search for other works by this author on:

,

University Medicine, Southampton General Hospital

,

Southampton

,

United Kingdom

Search for other works by this author on:

,

University Medicine, Southampton General Hospital

,

Southampton

,

United Kingdom

Search for other works by this author on:

,

University Medicine, Southampton General Hospital

,

Southampton

,

United Kingdom

Search for other works by this author on:

,

University Medicine, Southampton General Hospital

,

Southampton

,

United Kingdom

Search for other works by this author on:

,

University Medicine, Southampton General Hospital

,

Southampton

,

United Kingdom

Search for other works by this author on:

,

University Medicine, Southampton General Hospital

,

Southampton

,

United Kingdom

Search for other works by this author on:

... Show more

Received:

17 November 1999

Revision received:

08 February 2000

• • Article contents
  • Figures & tables
  • Video
  • Audio
  • Supplementary Data
• Cite

Cite

Nikolaos G. Papadopoulos, Philip J. Bates, Philip G. Bardin, Alberto Papi, Shih H. Leir, David J. Fraenkel, Jon Meyer, Peter M. Lackie, Gwendolyn Sanderson, Stephen T. Holgate, Sebastian L. Johnston, Rhinoviruses Infect the Lower Airways, The Journal of Infectious Diseases, Volume 181, Issue 6, June 2000, Pages 1875–1884, https://doi.org/10.1086/315513
Close

Navbar Search Filter Mobile Enter search term Search

Abstract

Rhinoviruses are the major cause of the common cold and a trigger of acute asthma exacerbations. Whether these exacerbations result from direct infection of the lower airway or from indirect mechanisms consequent on infection of the upper airway alone is currently unknown. Lower respiratory infection was investigated in vitro by exposing primary human bronchial epithelial cells to rhinoviruses and in vivo after experimental upper respiratory infection of human volunteers. Bronchial infection was confirmed by both approaches. Furthermore, rhinoviruses induced production of interleukin-6, -8, and -16 and RANTES and were cytotoxic to cultured respiratory epithelium. This evidence strongly supports a direct lower respiratory epithelial reaction as the initial event in the induction of rhinovirus-mediated asthma exacerbations. The frequency of infection and the nature of the inflammatory response observed are similar to those of the upper respiratory tract, suggesting that rhinovirus infections may be one of the most important causes of lower in addition to upper respiratory disease.

© 2000 by the Infectious Diseases Society of America

You do not currently have access to this article.

Personal account

• Sign in with email/username & password
• Get email alerts
• Save searches
• Purchase content
• Activate your purchase/trial code
• Add your ORCID iD

Get help with access

Institutional access

Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:

IP based access

Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.

Sign in through your institution

Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.

1. Click Sign in through your institution.
2. Select your institution from the list provided, which will take you to your institution's website to sign in.
3. When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
4. Following successful sign in, you will be returned to Oxford Academic.

If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.

Sign in with a library card

Enter your library card number to sign in. If you cannot sign in, please contact your librarian.

Society Members

Society member access to a journal is achieved in one of the following ways:

Sign in through society site

Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:

1. Click Sign in through society site.
2. When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
3. Following successful sign in, you will be returned to Oxford Academic.

If you do not have a society account or have forgotten your username or password, please contact your society.

Sign in using a personal account

Some societies use Oxford Academic personal accounts to provide access to their members. See below.

Personal account

A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.

Some societies use Oxford Academic personal accounts to provide access to their members.

Viewing your signed in accounts

Click the account icon in the top right to:

• View your signed in personal account and access account management features.
• View the institutional accounts that are providing access.

Signed in but can't access content

Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.

Institutional account management

For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.

Purchase

Short-term Access

To purchase short-term access, please sign in to your personal account above.

Don't already have a personal account? Register

Rhinoviruses Infect the Lower Airways - 24 Hours access

EUR €38.00

GBP £33.00

USD $41.00

Rental

This article is also available for rental through DeepDyve.

Citations

Views

Altmetric

Metrics

Total Views 3,090

2,293 Pageviews

797 PDF Downloads

Since 11/1/2016

Citations

402 Web of Science

×

Email alerts

More on this topic

Related articles in PubMed

Citing articles via

• Latest

• Most Read

• Most Cited

More from Oxford Academic