The Effect of Treatment of Vaginal Infections on Shedding of Human Immunodeficiency Virus Type 1 (original) (raw)

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1Medicine and Epidemiology, University of Washington, and

Reprints or correspondence: Dr. Chia C. Wang, University of Washington, Dept. of Medicine, Division of Infectious Diseases, 325 Ninth Ave., Box 359909, Seattle, WA 98104-2499 (chiaw@u.washington.edu).

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1Medicine and Epidemiology, University of Washington, and

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3Department of Epidemiology and Public Health, University College Cork, Cork, Ireland;

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2Fred Hutchinson Cancer Research Center, Seattle;

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2Fred Hutchinson Cancer Research Center, Seattle;

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4Coast Provincial General Hospital, Mombasa, and

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4Coast Provincial General Hospital, Mombasa, and

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5Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya

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5Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya

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1Medicine and Epidemiology, University of Washington, and

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Received:

10 October 2000

Revision received:

13 December 2000

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Chia C. Wang, R. Scott McClelland, Marie Reilly, Julie Overbaugh, Sandra R. Emery, Kishorchandra Mandaliya, Bhavna Chohan, Jeckoniah Ndinya-Achola, Job Bwayo, Joan K. Kreiss, The Effect of Treatment of Vaginal Infections on Shedding of Human Immunodeficiency Virus Type 1, The Journal of Infectious Diseases, Volume 183, Issue 7, 1 April 2001, Pages 1017–1022, https://doi.org/10.1086/319287
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Abstract

To assess the effect of treatment of vaginal infections on vaginal shedding of cell-free human immunodeficiency virus type 1 (HIV-1) and HIV-1–infected cells, HIV-1–seropositive women were examined before and after treatment of Candida vulvovaginitis, Trichomonas vaginitis, and bacterial vaginosis. For Candida (n=98), vaginal HIV-1 RNA decreased from 3.36 to 2.86 log10 copies/swab (P<.001), as did the prevalence of HIV-1 DNA (36% to 17%; odds ratio [OR], 2.8; 95% confidence interval [CI], 1.3–6.5). For Trichomonas vaginitis (n=55), HIV-1 RNA decreased from 3.67 to 3.05 log10 copies/swab (P<.001), but the prevalence of HIV-1 DNA remained unchanged (22%–25%; OR, 0.8; 95% CI, 0.3–2.2). For bacterial vaginosis (n=73), neither the shedding of HIV-1 RNA (from 3.11 to 2.90 log10 copies/swab; P=.14) nor the prevalence of DNA (from 21% to 23%; OR, 0.8; 95% CI, 0.3–2.0) changed. Vaginal HIV-1 decreased 3.2- and 4.2-fold after treating Candida and Trichomonas respectively. These data suggest that HIV-1 transmission intervention strategies that incorporate diagnosis and treatment of these prevalent infections warrant evaluation

© 2001 by the Infectious Diseases Society of America

Topic:

• vulvovaginal candidiasis
• dna
• hiv-1
• trichomonas vaginitis
• infections
• bacterial vaginosis
• vagina
• rna
• vaginitis, infective

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