Typhoid Fever and Genetic Polymorphisms at the Natural Resistance-Associated Macrophage Protein 1 (original) (raw)

Journal Article

,

1Department of Biochemistry, Imperial College of Science, Technology and Medicine, London,

Reprints or correspondence: Dr. Sarah Dunstan, Dept. of Biochemistry, Imperial College of Science, Technology and Medicine, London, SW7 2AZ, United Kingdom (s.dunstan@ic.ac.uk)

Search for other works by this author on:

,

4Dong Thap Provincial Hospital, Dong Thap,

Search for other works by this author on:

,

4Dong Thap Provincial Hospital, Dong Thap,

Search for other works by this author on:

,

4Dong Thap Provincial Hospital, Dong Thap,

Search for other works by this author on:

,

5Dong Nai Paediatric Centre, Bien Hoa, and

Search for other works by this author on:

,

6Centre for Tropical Diseases and Wellcome Trust Clinical Research Unit, Cho Quan Hospital, Ho Chi Minh City, Vietnam

Search for other works by this author on:

,

1Department of Biochemistry, Imperial College of Science, Technology and Medicine, London,

6Centre for Tropical Diseases and Wellcome Trust Clinical Research Unit, Cho Quan Hospital, Ho Chi Minh City, Vietnam

Search for other works by this author on:

,

2Wellcome Trust Centre for Molecular Mechanisms in Disease, Addenbrooke’s Hospital, Cambridge, and

Search for other works by this author on:

,

2Wellcome Trust Centre for Molecular Mechanisms in Disease, Addenbrooke’s Hospital, Cambridge, and

Search for other works by this author on:

,

1Department of Biochemistry, Imperial College of Science, Technology and Medicine, London,

6Centre for Tropical Diseases and Wellcome Trust Clinical Research Unit, Cho Quan Hospital, Ho Chi Minh City, Vietnam

Search for other works by this author on:

... Show more

Received:

10 October 2000

Revision received:

21 December 2000

• • Article contents
  • Figures & tables
  • Video
  • Audio
  • Supplementary Data
• Cite

Cite

Sarah J. Dunstan, Vo An Ho, Chau Minh Duc, Mai Ngoc Lanh, Cao Xuan Thanh Phuong, Christine Luxemburger, John Wain, Frank Dudbridge, Christopher S. Peacock, Deborah House, Christopher Parry, Tran Tinh Hien, Gordon Dougan, Jeremy Farrar, Jenefer M. Blackwell, Typhoid Fever and Genetic Polymorphisms at the Natural Resistance-Associated Macrophage Protein 1, The Journal of Infectious Diseases, Volume 183, Issue 7, 1 April 2001, Pages 1156–1160, https://doi.org/10.1086/319289
Close

Navbar Search Filter Mobile Enter search term Search

Abstract

Control of Salmonella enterica serovar Typhimurium (S. typhimurium) infection in the mouse model of typhoid fever is critically dependent on the natural resistance–associated macrophage protein 1 (Nramp1). In this study, we examined the role of genetic polymorphisms in the human homologue, NRAMP1 in resistance to typhoid fever in southern Vietnam. Patients with blood-culture–confirmed typhoid fever and healthy control subjects were genotyped for 6 polymorphic markers within and near NRAMP1 on chromosome 2q35. Four single base-pair polymorphisms (274 C/T, 469+14 G/C, 1465−85 G/A, and D543N), a (GT)n repeat in the promoter region of NRAMP1 and D2S1471, and a microsatellite marker ∼130-kb downstream of NRAMP1 were examined. The allelic and genotypic frequencies for each polymorphism were compared in case patients and control subjects. No allelic association was identified between the NRAMP1 alleles and typhoid fever susceptibility. In addition, neither homozygotes nor heterozygotes for any NRAMP1 variants were at increased risk of typhoid fever

© 2001 by the Infectious Diseases Society of America

Topic:

• alleles
• polymorphism
• enteric fever
• base pairing
• chromosomes
• genotype
• heterozygote
• homozygote
• immunity, natural
• macrophages
• promoter regions (genetics)
• salmonella enterica
• vietnam
• infections
• mice
• blood culture
• serotype

You do not currently have access to this article.

Personal account

• Sign in with email/username & password
• Get email alerts
• Save searches
• Purchase content
• Activate your purchase/trial code
• Add your ORCID iD

Get help with access

Institutional access

Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:

IP based access

Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.

Sign in through your institution

Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.

1. Click Sign in through your institution.
2. Select your institution from the list provided, which will take you to your institution's website to sign in.
3. When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
4. Following successful sign in, you will be returned to Oxford Academic.

If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.

Sign in with a library card

Enter your library card number to sign in. If you cannot sign in, please contact your librarian.

Society Members

Society member access to a journal is achieved in one of the following ways:

Sign in through society site

Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:

1. Click Sign in through society site.
2. When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
3. Following successful sign in, you will be returned to Oxford Academic.

If you do not have a society account or have forgotten your username or password, please contact your society.

Sign in using a personal account

Some societies use Oxford Academic personal accounts to provide access to their members. See below.

Personal account

A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.

Some societies use Oxford Academic personal accounts to provide access to their members.

Viewing your signed in accounts

Click the account icon in the top right to:

• View your signed in personal account and access account management features.
• View the institutional accounts that are providing access.

Signed in but can't access content

Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.

Institutional account management

For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.

Purchase

Short-term Access

To purchase short-term access, please sign in to your personal account above.

Don't already have a personal account? Register

Typhoid Fever and Genetic Polymorphisms at the Natural Resistance-Associated Macrophage Protein 1 - 24 Hours access

EUR €38.00

GBP £33.00

USD $41.00

Rental

This article is also available for rental through DeepDyve.

Citations

Views

Altmetric

Metrics

Total Views 1,252

975 Pageviews

277 PDF Downloads

Since 11/1/2016

Citations

31 Web of Science

×

Email alerts

More on this topic

Related articles in PubMed

Citing articles via

• Latest

• Most Read

• Most Cited

More from Oxford Academic