Persistent Abnormalities in Lymphoid Tissues of Human Immunodeficiency Virus–Infected Patients Successfully Treated with Highly Active Antiretroviral Therapy (original) (raw)

Journal Article

,

Reprints or correspondence: Dr. Timothy W. Schacker, Dept. of Medicine, University of Minnesota, MMC 250, 516 Delaware St., Minneapolis, MN 55455 (schacker@lenti.med.umn.edu)

Search for other works by this author on:

,

Search for other works by this author on:

,

7Hospital Clinic, University Hospital, Barcelona, Spain;

Search for other works by this author on:

,

Search for other works by this author on:

,

7Hospital Clinic, University Hospital, Barcelona, Spain;

Search for other works by this author on:

,

6Centrum Diagnostyki Therapy AIDS, Warsaw, Poland;

Search for other works by this author on:

,

6Centrum Diagnostyki Therapy AIDS, Warsaw, Poland;

Search for other works by this author on:

,

5Northwestern University Medical School, Chicago, Illinois;

Search for other works by this author on:

,

8International Antiviral Therapy Evaluation Centre, Amsterdam, The Netherlands

Search for other works by this author on:

,

5Northwestern University Medical School, Chicago, Illinois;

Search for other works by this author on:

... Show more

Revision received:

31 May 2002

Published:

15 October 2002

• • Article contents
  • Figures & tables
  • Video
  • Audio
  • Supplementary Data
• Cite

Cite

Timothy W. Schacker, Phuong L. Nguyen, Esteban Martinez, Cavan Reilly, Jose M. Gatell, Andrzej Horban, Elzbieta Bakowska, Baiba Berzins, Remko van Leeuwen, Steven Wolinsky, Ashley T. Haase, Robert L. Murphy, Persistent Abnormalities in Lymphoid Tissues of Human Immunodeficiency Virus–Infected Patients Successfully Treated with Highly Active Antiretroviral Therapy, The Journal of Infectious Diseases, Volume 186, Issue 8, 15 October 2002, Pages 1092–1097, https://doi.org/10.1086/343802
Close

Navbar Search Filter Mobile Enter search term Search

Abstract

Effective highly active antiretroviral therapy (HAART) for human immunodeficiency virus type 1 is associated with virus suppression and immune reconstitution. However, in some patients, this reconstitution is partial or incomplete because CD4+ cell counts do not increase significantly. This may be due to damage in the microenvironment of lymphoid tissues (LTs), where CD4+ T cells reside. To test this hypothesis, LT samples were obtained from 23 patients enrolled in a prospective trial that compared 3 different HAART regimens. Analysis of LT architecture and CD4+ T cells populations revealed abnormalities in 100% of the LT samples, especially in the follicles, with 43% showing absence, 14% showing regression, and 43% showing hyperplasia. CD4+ T cell populations were abnormal in 16 (89%) of 18 tissue samples, with 7 (39%) of 18 decreased by >50% of normal levels. These data are consistent with the hypothesis that persistent abnormalities in the microenvironment can influence immune reconstitution and document persistent LT abnormalities with HAART not detected by measures of peripheral CD4+ T cell count

© 2002 by the Infectious Diseases Society of America

Topic:

• hiv
• antiretroviral therapy, highly active
• cell count
• hair follicle
• hiv-1
• hyperplasia
• leukotrienes
• lymphoid tissue
• ovarian follicle
• t-lymphocytes
• viruses
• persistence
• immune reconstitution
• tissue specimen

You do not currently have access to this article.

Personal account

• Sign in with email/username & password
• Get email alerts
• Save searches
• Purchase content
• Activate your purchase/trial code
• Add your ORCID iD

Get help with access

Institutional access

Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:

IP based access

Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.

Sign in through your institution

Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.

1. Click Sign in through your institution.
2. Select your institution from the list provided, which will take you to your institution's website to sign in.
3. When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
4. Following successful sign in, you will be returned to Oxford Academic.

If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.

Sign in with a library card

Enter your library card number to sign in. If you cannot sign in, please contact your librarian.

Society Members

Society member access to a journal is achieved in one of the following ways:

Sign in through society site

Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:

1. Click Sign in through society site.
2. When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
3. Following successful sign in, you will be returned to Oxford Academic.

If you do not have a society account or have forgotten your username or password, please contact your society.

Sign in using a personal account

Some societies use Oxford Academic personal accounts to provide access to their members. See below.

Personal account

A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.

Some societies use Oxford Academic personal accounts to provide access to their members.

Viewing your signed in accounts

Click the account icon in the top right to:

• View your signed in personal account and access account management features.
• View the institutional accounts that are providing access.

Signed in but can't access content

Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.

Institutional account management

For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.

Purchase

Short-term Access

To purchase short-term access, please sign in to your personal account above.

Don't already have a personal account? Register

Persistent Abnormalities in Lymphoid Tissues of Human Immunodeficiency Virus–Infected Patients Successfully Treated with Highly Active Antiretroviral Therapy

- 24 Hours access

EUR €38.00

GBP £33.00

USD $41.00

Rental

This article is also available for rental through DeepDyve.

Citations

Views

Altmetric

Metrics

Total Views 859

607 Pageviews

252 PDF Downloads

Since 1/1/2017

Citations

57 Web of Science

×

Email alerts

More on this topic

Related articles in PubMed

Citing articles via

• Latest

• Most Read

• Most Cited

More from Oxford Academic