Quantification and Functional Analysis of Plasmacytoid Dendritic Cells in Patients with Chronic Hepatitis C Virus Infection (original) (raw)

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Unité Mixte de Recherche (UMR) 2142, Centre National de la Recherche Scientifique (CNRS) Biomérieux

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Lyon

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Centre Hospitalier Universitaire Pessac

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Pessac, France

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Centre Hospitalier Universitaire Pessac

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Pessac, France

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Unité Mixte de Recherche (UMR) 2142, Centre National de la Recherche Scientifique (CNRS) Biomérieux

,

Lyon

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Unité Mixte de Recherche (UMR) 2142, Centre National de la Recherche Scientifique (CNRS) Biomérieux

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Lyon

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Accepted:

23 October 2003

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Nadège Goutagny, Claude Vieux, Evelyne Decullier, Benoît Ligeoix, Alberto Epstein, Christian Trépo, Patrice Couzigou, Geneviève Inchauspé, Christine Bain, Quantification and Functional Analysis of Plasmacytoid Dendritic Cells in Patients with Chronic Hepatitis C Virus Infection, The Journal of Infectious Diseases, Volume 189, Issue 9, 1 May 2004, Pages 1646–1655, https://doi.org/10.1086/383248
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Abstract

Background. Plasmacytoid dendritic cells (PDCs) are the major producers of interferon (IFN)-α within peripheral blood mononuclear cells (PBMCs).

Methods. We analyzed whether chronic hepatitis C virus (HCV) infection could be linked to a defective function or number of PDCs. We evaluated the capacity of PBMCs from 5 cohorts of subjects to produce IFN-α after viral stimulation. We concomitantly analyzed the frequency of PDCs and the levels of IFN-α transcripts within the PBMCs from the same cohorts.

Results. PBMCs from patients with chronic HCV infection receiving antiviral therapy displayed a reduced capacity to release IFN-α, compared with those from healthy individuals, those from long-term responders to therapy, and those from nontreated patients. This defect was significantly correlated with the percentage of PDCs. In addition, PDCs from patients with chronic HCV infection receiving therapy displayed a reduced intrinsic capacity to produce IFN-α, which could be linked to the level of IFN-α transcripts.

Conclusion. Our observations point to an effect of the therapy on either the survival or the localization of PDCs, rather than a direct detrimental effect due to the viral infection during chronic HCV infection.

© 2004 by the Infectious Diseases Society of America

Topic:

• hepatitis c, chronic
• antiviral agents
• dendritic cells
• interferons
• virus diseases
• infections
• viruses
• human leukocyte interferon
• hepatitis c virus
• peripheral blood mononuclear cell

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