The Respiratory Pathogen Moraxella catarrhalis Adheres to Epithelial Cells by Interacting with Fibronectin through Ubiquitous Surface Proteins A1 and A2 (original) (raw)

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,

1Medical Microbiology, Department of Laboratory Medicine, Malmö University Hospital, Lund University, Malmö, Sweden;

2Department of Internal Medicine, Singapore General Hospital, Singapore

Reprints or correspondence: Dr. Kristian Riesbeck, Medical Microbiology, Dept. of Laboratory Medicine, Malmö University Hospital, Lund University, SE-205 02 Malmö, Sweden (kristian.riesbeck@med.lu.se)

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1Medical Microbiology, Department of Laboratory Medicine, Malmö University Hospital, Lund University, Malmö, Sweden;

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,

1Medical Microbiology, Department of Laboratory Medicine, Malmö University Hospital, Lund University, Malmö, Sweden;

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1Medical Microbiology, Department of Laboratory Medicine, Malmö University Hospital, Lund University, Malmö, Sweden;

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Received:

02 November 2004

Published:

15 September 2005

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Thuan Tong Tan, Therése Nordström, Arne Forsgren, Kristian Riesbeck, The Respiratory Pathogen Moraxella catarrhalis Adheres to Epithelial Cells by Interacting with Fibronectin through Ubiquitous Surface Proteins A1 and A2, The Journal of Infectious Diseases, Volume 192, Issue 6, 15 September 2005, Pages 1029–1038, https://doi.org/10.1086/432759
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Abstract

Moraxella catarrhalis ubiquitous surface protein (Usp) A1 has been reported to bind fibronectin and is involved in adherence. In this study, using M. catarrhalis mutants derived from clinical isolates, we show that both UspA1 and UspA2 bind fibronectin. Recombinant truncated UspA1/A2 proteins, together with smaller fragments spanning the entire molecule, were tested for binding to fibronectin. Both UspA1 and UspA2 bound fibronectin, and the fibronectin-binding domains were located within UspA1299–452 and UspA2165–318. These 2 truncated proteins inhibited binding of M. catarrhalis to Chang conjunctival epithelial cells to an extent similar to that by anti-human fibronectin antibodies. Our observations show that both UspA1 and UspA2 are involved in adherence to epithelial cells via cell-associated fibronectin. The biologically active sites within UspA1299–452 and UspA2165–318 have therefore been suggested to be potential candidates to be included in a future vaccine against M. catarrhalis

© 2005 by the Infectious Diseases Society of America

Topic:

• fibronectins
• membrane proteins
• moraxella (branhamella) catarrhalis
• pathogenic organism
• epithelial cells
• united states pharmacopeia
• binding (molecular function)
• heart sound a2
• conjunctival epithelial cells

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