A Molecular Epidemiological Approach to Studying the Transmission of Tuberculosis in Amsterdam (original) (raw)

Journal Article

,

From the

Tuberculosis Department, Municipal Health Service

,

Amsterdam

; and the

Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment

,

Bilthoven, the Netherlands

Reprints or correspondence: Dr. H. van Deutekom, Tuberculosis Department, Municipal Health Service, P.O. Box 20244, 1000 HE Amsterdam, the Netherlands.

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,

From the

Tuberculosis Department, Municipal Health Service

,

Amsterdam

; and the

Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment

,

Bilthoven, the Netherlands

Search for other works by this author on:

,

From the

Tuberculosis Department, Municipal Health Service

,

Amsterdam

; and the

Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment

,

Bilthoven, the Netherlands

Search for other works by this author on:

,

From the

Tuberculosis Department, Municipal Health Service

,

Amsterdam

; and the

Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment

,

Bilthoven, the Netherlands

Search for other works by this author on:

,

From the

Tuberculosis Department, Municipal Health Service

,

Amsterdam

; and the

Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment

,

Bilthoven, the Netherlands

Search for other works by this author on:

From the

Tuberculosis Department, Municipal Health Service

,

Amsterdam

; and the

Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment

,

Bilthoven, the Netherlands

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Received:

21 November 1996

Revision received:

26 March 1997

Published:

01 November 1997

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H. van Deutekom, J. J. J. Gerritsen, D. van Soolingen, E. J. C. van Ameijden, J. D. A. van Embden, R. A. Coutinho, A Molecular Epidemiological Approach to Studying the Transmission of Tuberculosis in Amsterdam, Clinical Infectious Diseases, Volume 25, Issue 5, November 1997, Pages 1071–1077, https://doi.org/10.1086/516072
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Abstract

We conducted a retrospective, population-based study with use of restriction fragment length polymorphism (RFLP) analysis to determine the incidence of and risk factors for clustering of Mycobacterium tuberculosis isolates, indicative of recently transmitted infection, among patients with culture-proven tuberculosis diagnosed between 1 July 1992 and 1 January 1995 in Amsterdam. We found that 214 (47%) of 459 patients were in 53 clusters, probably because of recent transmission of M. tuberculosis among 161 (35%) of these patients. Conventional contact tracing resulted in identification of 5.6% of the 161 patients. Clustering was more frequent among Dutch patients (59.3%) than among foreign ethnic patients (42.1%) (P = .002). The independent risk factor for clustering among Dutch patients was younger age; the independent risk factors among foreign ethnic patients were hard-drug use; alcohol abuse; and country of origin (Surinam or the Netherlands Antilles). These findings suggest the shortcomings of the usual tuberculosis control policies in Amsterdam. We identified several risk factors for clustering, which may guide adjustment of tuberculosis control and contact tracing strategies.

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© 1997 by The University of Chicago

Topic:

• alcohol abuse
• infectious disease contact tracing
• mycobacterium tuberculosis
• netherlands antilles
• restriction fragment length polymorphism
• suriname
• tuberculosis
• infections

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