Human Parechoviruses as an Important Viral Cause of Sepsislike Illness and Meningitis in Young Children (original) (raw)

Journal Article

,

1

Department of Medical Microbiology, Laboratory of Clinical Virology

,

Amsterdam, The Netherlands

Reprints or correspondence: Dr. Katja C. Wolthers, Dept. of Medical Microbiology, Laboratory of Clinical Virology K1-121, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands (k.c.wolthers@amc.uva.nl).

Search for other works by this author on:

,

1

Department of Medical Microbiology, Laboratory of Clinical Virology

,

Amsterdam, The Netherlands

Search for other works by this author on:

,

1

Department of Medical Microbiology, Laboratory of Clinical Virology

,

Amsterdam, The Netherlands

Search for other works by this author on:

,

1

Department of Medical Microbiology, Laboratory of Clinical Virology

,

Amsterdam, The Netherlands

Search for other works by this author on:

,

1

Department of Medical Microbiology, Laboratory of Clinical Virology

,

Amsterdam, The Netherlands

Search for other works by this author on:

,

3

Departments of Medical Microbiology, Onze Lieve Vrouwe Gasthuis

,

Amsterdam, The Netherlands

Search for other works by this author on:

,

4

Departments of Pediatrics, Onze Lieve Vrouwe Gasthuis

,

Amsterdam, The Netherlands

Search for other works by this author on:

2

Department of Pediatric Infectious Diseases, Emma Children's Hospital, Academic Medical Center, University of Amsterdam

,

Amsterdam, The Netherlands

Search for other works by this author on:

Received:

19 December 2007

Published:

01 August 2008

• • Article contents
  • Figures & tables
  • Video
  • Audio
  • Supplementary Data
• Cite

Cite

Katja C. Wolthers, Kimberley S. M. Benschop, Janke Schinkel, Richard Molenkamp, Rosemarijn M. Bergevoet, Ingrid J. B. Spijkerman, H. Carlijn Kraakman, Dasja Pajkrt, Human Parechoviruses as an Important Viral Cause of Sepsislike Illness and Meningitis in Young Children, Clinical Infectious Diseases, Volume 47, Issue 3, 1 August 2008, Pages 358–363, https://doi.org/10.1086/589752
Close

Navbar Search Filter Mobile Enter search term Search

Abstract

Background. Enteroviruses (EVs) belong to the family Picornaviridae and are a well-known cause of neonatal sepsis and viral meningitis. Human parechoviruses (HPeVs) type 1 and 2, previously named echovirus 22 and 23, have been associated with mild gastrointestinal or respiratory symptoms in young children. Six HPeV genotypes are currently known, of which HPeV3 is associated with neonatal sepsis and meningitis.

Methods. Cerebrospinal fluid samples from children aged <5 years previously tested by EV-specific polymerase chain reaction (PCR) during 2004–2006 were selected (n=761). Samples from 716 of those children were available for retrospective testing by HPeV-specific real-time PCR. The prevalence of EV and HPeV in these samples was compared. Data on clinical presentation of children infected with HPeV were retrospectively documented.

Results. HPeV was found in cerebrospinal fluid samples from 33 (4.6%) of the children. Yearly prevalence of HPeV in cerebrospinal fluid varied remarkably: 8.2% in 2004, 0.4% in 2005, and 5.7% in 2006. EV was detected in 14% (108 of 761 samples), with no variation in yearly prevalence. Children with HPeV in cerebrospinal fluid presented with clinical symptoms of sepsislike illness and meningitis, which led to hospitalization and antibiotic treatment.

Conclusion. EV-specific PCRs do not detect HPeVs. The addition of an HPeV-specific PCR has led to a 31% increase in detection of a viral cause of neonatal sepsis or central nervous system symptoms in children aged <5 years. HPeV can be considered to be the second cause of viral sepsis and meningitis in young children, and rapid identification of HPeV by PCR could contribute to shorter duration of both antibiotic use and hospital stay.

© 2008 by the Infectious Diseases Society of America

Topic:

• antibiotics
• polymerase chain reaction
• meningitis
• enterovirus
• child
• genotype
• parechovirus
• cerebrospinal fluid
• sepsis of the newborn

You do not currently have access to this article.

Personal account

• Sign in with email/username & password
• Get email alerts
• Save searches
• Purchase content
• Activate your purchase/trial code
• Add your ORCID iD

Get help with access

Institutional access

Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:

IP based access

Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.

Sign in through your institution

Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.

1. Click Sign in through your institution.
2. Select your institution from the list provided, which will take you to your institution's website to sign in.
3. When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
4. Following successful sign in, you will be returned to Oxford Academic.

If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.

Sign in with a library card

Enter your library card number to sign in. If you cannot sign in, please contact your librarian.

Society Members

Society member access to a journal is achieved in one of the following ways:

Sign in through society site

Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:

1. Click Sign in through society site.
2. When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
3. Following successful sign in, you will be returned to Oxford Academic.

If you do not have a society account or have forgotten your username or password, please contact your society.

Sign in using a personal account

Some societies use Oxford Academic personal accounts to provide access to their members. See below.

Personal account

A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.

Some societies use Oxford Academic personal accounts to provide access to their members.

Viewing your signed in accounts

Click the account icon in the top right to:

• View your signed in personal account and access account management features.
• View the institutional accounts that are providing access.

Signed in but can't access content

Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.

Institutional account management

For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.

Purchase

Short-term Access

To purchase short-term access, please sign in to your personal account above.

Don't already have a personal account? Register

Human Parechoviruses as an Important Viral Cause of Sepsislike Illness and Meningitis in Young Children - 24 Hours access

EUR €38.00

GBP £33.00

USD $41.00

Rental

This article is also available for rental through DeepDyve.

Citations

Views

Altmetric

Metrics

Total Views 9,741

8,754 Pageviews

987 PDF Downloads

Since 12/1/2016

Citations

187 Web of Science

×

Email alerts

More on this topic

Related articles in PubMed

Citing articles via

• Latest

• Most Read

• Most Cited

More from Oxford Academic