Young Infants Can Develop Protective Levels of Neutralizing Antibody after Infection with Respiratory Syncytial Virus (original) (raw)

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Department of International Health, Bloomberg School of Public Health, Johns Hopkins University

,

Baltimore, Maryland

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Department of International Health, Bloomberg School of Public Health, Johns Hopkins University

,

Baltimore, Maryland

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,

Department of International Health, Bloomberg School of Public Health, Johns Hopkins University

,

Baltimore, Maryland

Search for other works by this author on:

,

Department of International Health, Bloomberg School of Public Health, Johns Hopkins University

,

Baltimore, Maryland

Search for other works by this author on:

,

Department of International Health, Bloomberg School of Public Health, Johns Hopkins University

,

Baltimore, Maryland

Search for other works by this author on:

,

Department of International Health, Bloomberg School of Public Health, Johns Hopkins University

,

Baltimore, Maryland

Search for other works by this author on:

,

Department of International Health, Bloomberg School of Public Health, Johns Hopkins University

,

Baltimore, Maryland

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Department of International Health, Bloomberg School of Public Health, Johns Hopkins University

,

Baltimore, Maryland

Reprints or correspondence: Dr. Ruth Karron, Center for Immunization Research, Hampton House 217, Johns Hopkins Bloomberg School of Public Health, 624 N. Broadway, Baltimore, MD 21205 (rkarron@jhsph.edu).

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Received:

27 December 2007

Published:

01 October 2008

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Joshua J. Shinoff, Katherine L. O'Brien, Bhagvanji Thumar, Jana B. Shaw, Raymond Reid, Wei Hua, Mathuram Santosham, Ruth Karron, Young Infants Can Develop Protective Levels of Neutralizing Antibody after Infection with Respiratory Syncytial Virus, The Journal of Infectious Diseases, Volume 198, Issue 7, 1 October 2008, Pages 1007–1015, https://doi.org/10.1086/591460
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Abstract

Humoral immunity protects against severe respiratory syncytial virus (RSV) disease, but the range and magnitude of antibody responses in RSV-naive children after RSV infection have not been completely defined. We evaluated RSV-neutralizing antibody and immunoglobulin G responses to RSV F and G glycoproteins in 65 RSV-naive Navajo and White Mountain Apache children aged 0–24 months who were hospitalized with RSV infection. In these children, antibody responses developed against RSV F and G and the central conserved region of RSV G. Twenty-seven of 41 infants <6 months old developed reciprocal log2RSV neutralizing antibody titers ⩾8.0, which correlate with protection of the lower respiratory tract. Multivariate analysis demonstrated that the level of preexisting neutralizing antibody at infection, not age, was the most important factor influencing this response. RSV can induce substantial neutralizing antibody responses in young infants when the titer of pre-existing antibodies is low.

© 2008 by the Infectious Diseases Society of America

Topic:

• glycoproteins
• antibody formation
• child
• infant
• respiratory syncytial virus infections
• respiratory syncytial viruses
• immunoglobulin g
• infections
• antibodies
• apache
• neutralizing antibodies

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