Overexpression of p53 Protein in Adenocarcinoma of the Pancreas (original) (raw)

Journal Article

,

Joseph A. DiGiuseppe, MD, PhD

1 From The Departments of Pathology, The Academic Medical Center, Amsterdam, The Netherlands.

Search for other works by this author on:

,

1 From The Departments of Pathology, The Academic Medical Center, Amsterdam, The Netherlands.

Search for other works by this author on:

,

Steven N. Goodman, MD, PhD

2 Department of Oncology Biostatistics, Epidemiology, The Academic Medical Center, Amsterdam, The Netherlands.

Search for other works by this author on:

,

3 Department of Pathology, The Academic Medical Center, Amsterdam, The Netherlands.

Search for other works by this author on:

,

Frank M. Van Den Berg, PhD

3 Department of Pathology, The Academic Medical Center, Amsterdam, The Netherlands.

Search for other works by this author on:

,

4 Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland.

Search for other works by this author on:

,

4 Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland.

Search for other works by this author on:

G. Johan A. Offerhaus, MD, PhD

3 Department of Pathology, The Academic Medical Center, Amsterdam, The Netherlands.

Search for other works by this author on:

Received:

09 February 1993

• • Article contents
  • Figures & tables
  • Video
  • Audio
  • Supplementary Data
• Cite

Cite

Joseph A. DiGiuseppe, Ralph H. Hruban, Steven N. Goodman, Miriam Polak, Frank M. Van Den Berg, David C. Allison, John L. Cameron, G. Johan A. Offerhaus, Overexpression of p53 Protein in Adenocarcinoma of the Pancreas, American Journal of Clinical Pathology, Volume 101, Issue 6, 1 June 1994, Pages 684–688, https://doi.org/10.1093/ajcp/101.6.684
Close

Navbar Search Filter Mobile Enter search term Search

Abstract

Mutations in the p53 tumor suppressor gene are frequently identified in human neoplasms. These mutations may be associated with stabilization and, therefore, with overexpression of the p53 protein product as determined by immunohistochemical staining. Using a new antigen retrieval method and a polyclonal antibody to p53 (CM-1), the authors examined 48 formalin-fixed paraffin-embedded adenocarcinomas of the pancreas for overexpression of the p53 gene product. These 48 carcinomas were obtained from a series of patients with well-documented clinical histories and extensive follow-up. The carcinomas had been analyzed previously for K-ras gene mutations, tumor ploidy, and tumor proliferating index. Specific diffuse nuclear staining for the p53 protein was identified in 19 of the 48 (40%) infiltrating carcinomas examined. Focal or negative staining was seen in the remaining 29 cases (60%). In addition, 17 of the neoplasms contained synchronous in situ carcinomas; two (12%) of these displayed diffuse nuclear staining for the p53 protein. Overexpression of p53 was associated with aneuploidy (P = .05), which had been a poor prognosticator in this series of adenocarcinomas of the pancreas. Although overexpression of p53 appeared to be associated with poor prognosis (hazard ratio, 1.8; P = .07), this was not statistically significant. Overexpression of p53 was not significantly associated with K-ras oncogene mutations or tumor proliferating index. The authors conclude that overexpression of the p53 protein occurs frequently in invasive adenocarcinomas of the pancreas and in some in situ carcinomas, as well.

This content is only available as a PDF.

© American Society of Clinical Pathologists

You do not currently have access to this article.

Personal account

• Sign in with email/username & password
• Get email alerts
• Save searches
• Purchase content
• Activate your purchase/trial code
• Add your ORCID iD

Get help with access

Institutional access

Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:

IP based access

Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.

Sign in through your institution

Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.

1. Click Sign in through your institution.
2. Select your institution from the list provided, which will take you to your institution's website to sign in.
3. When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
4. Following successful sign in, you will be returned to Oxford Academic.

If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.

Sign in with a library card

Enter your library card number to sign in. If you cannot sign in, please contact your librarian.

Society Members

Society member access to a journal is achieved in one of the following ways:

Sign in through society site

Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:

1. Click Sign in through society site.
2. When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
3. Following successful sign in, you will be returned to Oxford Academic.

If you do not have a society account or have forgotten your username or password, please contact your society.

Sign in using a personal account

Some societies use Oxford Academic personal accounts to provide access to their members. See below.

Personal account

A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.

Some societies use Oxford Academic personal accounts to provide access to their members.

Viewing your signed in accounts

Click the account icon in the top right to:

• View your signed in personal account and access account management features.
• View the institutional accounts that are providing access.

Signed in but can't access content

Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.

Institutional account management

For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.

Purchase

Short-term Access

To purchase short-term access, please sign in to your personal account above.

Don't already have a personal account? Register

Overexpression of p53 Protein in Adenocarcinoma of the Pancreas - 24 Hours access

EUR €38.00

GBP £33.00

USD $41.00

Rental

This article is also available for rental through DeepDyve.

Citations

Views

Altmetric

Metrics

Total Views 88

28 Pageviews

60 PDF Downloads

Since 12/1/2016

Citations

186 Web of Science

×

Email alerts

Citing articles via

• Latest

• Most Read

• Most Cited

More from Oxford Academic