FRONTO-STRIATAL COGNITIVE DEFICITS AT DIFFERENT STAGES OF PARKINSON'S DISEASE (original) (raw)

Journal Article

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1

Department of Experimental Psychology, University of Cambridge

London, UK

Correspondence to: Dr A. M. Owen, Department of Experimental Psychology, Downing Street, Cambridge CB2 3EB, UK.

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2

Department of Psychology, The National Hospital for Neurology and Neurosurgery

London, UK

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3

Department of Neurology, Institute of Psychiatry

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3

Department of Neurology, Institute of Psychiatry

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4

Department of Clinical Neurology, Institute of Neurology

London, UK

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4

Department of Clinical Neurology, Institute of Neurology

London, UK

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Department of Clinical Neurology, Institute of Neurology

London, UK

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Department of Experimental Psychology, University of Cambridge

London, UK

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Published:

01 December 1992

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A. M. OWEN, M. JAMES, P. N. LEIGH, B. A. SUMMERS, C. D. MARSDEN, N. P. QUINN, K. W. LANGE, T. W. ROBBINS, FRONTO-STRIATAL COGNITIVE DEFICITS AT DIFFERENT STAGES OF PARKINSON'S DISEASE, Brain, Volume 115, Issue 6, December 1992, Pages 1727–1751, https://doi.org/10.1093/brain/115.6.1727
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Abstract

Groups of patients with idiopathic Parkinson's disease, either medicated or unmedicated, were compared with matched groups of normal controls on a computerized battery previously shown to be sensitive to frontal lobe dysfunction, including tests of planning, spatial working memory and attentional set-shifting. In a series of problems based on the ‘Tower of London’ test, medicated patients with Parkinson's disease were shown to be impaired in the amount of time spent thinking about (planning) the solution to each problem. Additionally, an impairment in terms of the accuracy of the solution produced on this test was only evident in those patients with more severe clinical symptoms and was accompanied by deficits in an associated test of spatial short-term memory. Medicated patients with both mild and severe clinical symptoms were also impaired on a related test of spatial working memory. In contrast, a group of patients who were unmedicated and ‘early in the course’ of the disease were unimpaired in all three of these tests. However, all three Parkinson's disease groups were impaired in the test of attentional set-shifting ability, although unimpaired in a test of pattern recognition which is insensitive to frontal lobe damage.

These data are compared with those previously published from a group of young neurosurgical patients with localized excisions of the frontal lobes and are discussed in terms of the specific nature of the cognitive deficit at different stages of Parkinson's diseas.

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Topic:

• parkinson disease
• short-term memory
• pattern recognition
• frontal lobe
• neurosurgical procedures
• cognitive impairment
• batteries
• excision

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