Functional MRI measurement of language Lateralization in Wada-tested patients (original) (raw)

Journal Article

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1

Departments of Radiology, Stanford University

Stanford, USA

3

Departments of Psychology, Stanford University

Stanford, USA

Correspondence to: John E. Desmond, Department of Psychology, Stanford University, Stanford, CA 94305, USA

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Departments of Neurology, Stanford University

Stanford, USA

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Departments of Psychology, Stanford University

Stanford, USA

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Departments of Psychology, Stanford University

Stanford, USA

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Departments of Psychiatry and Behavioral Sciences, Stanford University

Stanford, USA

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Departments of Radiology, Stanford University

Stanford, USA

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Departments of Psychology, Stanford University

Stanford, USA

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Departments of Neurology, Stanford University

Stanford, USA

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Received:

17 February 1995

Revision received:

11 July 1995

Published:

01 December 1995

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J. E. Desmond, J. M. Sum, A. D. Wagner, J. B. Demb, P. K. Shear, G. H. Glover, J. D. E. Gabrieli, M. J. Morrell, Functional MRI measurement of language Lateralization in Wada-tested patients, Brain, Volume 118, Issue 6, December 1995, Pages 1411–1419, https://doi.org/10.1093/brain/118.6.1411
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Abstract

Summary

In this study the use of functional MRI (fMRI) for measuring language lateralization non-invasively was examined. The subjects were seven patients with histories of temporal lobe epilepsy who had undergone Wada resting for pre-surgical evaluation. Four patients were left-hemisphere-dominant and three were right-hemisphere-dominant for language. They received fMRI scans while they made semantic or perceptual judgments about visually presented words. Regions of the inferior frontal gyrus (pars triangularis and pars orbitalis) and neighbouring orbital cortex, corresponding to portions of Brodmann areas 45, 46 and 47, exhibited significant increases in activation during semantic relative to perceptual judgments. Lateralization of the increases in activation were consistent with the Wada test assessments of hemispheric language dominance in each of the seven patients. These results suggest that, in addition to providing a tool for investigating human cognitive processes, fMRI has significant clinical potential as a non-invasive measure of language laterlization.

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Topic:

• epilepsy, temporal lobe
• judgment
• languages
• mental processes
• poly(adp-ribose) polymerases
• semantics
• surgical procedures, operative
• functional magnetic resonance imaging
• brodmann area
• orbital gyrus

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