Clinicopathological and imaging correlates of progressive aphasia and apraxia of speech (original) (raw)

Journal Article

,

11

Departments of Neurology, Divisions of Behavioral Neurology

Mayo Clinic, Rochester, MN, USA

22

Departments of Neurology, Divisions of Movement Disorders

Mayo Clinic, Rochester, MN, USA

Correspondence to: Keith A. Josephs, MST, MD, Department of Neurology, Divisions of Movement Disorders and Behavioral Neurology, Mayo Clinic, Rochester, MN 55905, USA E-mail: josephs.keith@mayo.edu

Search for other works by this author on:

,

33

Departments of Neurology, Divisions of Speech Pathology

Mayo Clinic, Rochester, MN, USA

Search for other works by this author on:

,

33

Departments of Neurology, Divisions of Speech Pathology

Mayo Clinic, Rochester, MN, USA

Search for other works by this author on:

,

44

Departments of Neurology, Radiology Research

Mayo Clinic, Rochester, MN, USA

Search for other works by this author on:

,

77

Departments of Neurology, Diagnostic Radiology

Mayo Clinic, Rochester, MN, USA

Search for other works by this author on:

,

55

Departments of Neurology, Laboratory Medicine and Pathology

Mayo Clinic, Rochester, MN, USA

Search for other works by this author on:

,

66

Departments of Neurology, Nuclear Medicine

Mayo Clinic, Rochester, MN, USA

88

Division of Neuroscience (Neuropathology)

Mayo Clinic, Jacksonville, FL, USA

Search for other works by this author on:

,

77

Departments of Neurology, Diagnostic Radiology

Mayo Clinic, Rochester, MN, USA

Search for other works by this author on:

,

11

Departments of Neurology, Divisions of Behavioral Neurology

Mayo Clinic, Rochester, MN, USA

22

Departments of Neurology, Divisions of Movement Disorders

Mayo Clinic, Rochester, MN, USA

Search for other works by this author on:

,

11

Departments of Neurology, Divisions of Behavioral Neurology

Mayo Clinic, Rochester, MN, USA

Search for other works by this author on:

... Show more

Received:

21 September 2005

Revision received:

03 March 2006

• • Article contents
  • Figures & tables
  • Video
  • Audio
  • Supplementary Data
• Cite

Cite

Keith A. Josephs, Joseph R. Duffy, Edyth A. Strand, Jennifer L. Whitwell, Kenneth F. Layton, Joseph E. Parisi, Mary F. Hauser, Robert J. Witte, Bradley F. Boeve, David S. Knopman, Dennis W. Dickson, Clifford R. Jack, Ronald C. Petersen, Clinicopathological and imaging correlates of progressive aphasia and apraxia of speech, Brain, Volume 129, Issue 6, June 2006, Pages 1385–1398, https://doi.org/10.1093/brain/awl078
Close

Navbar Search Filter Mobile Enter search term Search

Abstract

Apraxia of speech (AOS) is a motor speech disorder characterized by slow speaking rate, abnormal prosody and distorted sound substitutions, additions, repetitions and prolongations, sometimes accompanied by groping, and trial and error articulatory movements. Although AOS is frequently subsumed under the heading of aphasia, and indeed most often co-occurs with aphasia, it can be the predominant or even the sole manifestation of a degenerative neurological disease. In this study we determine whether the clinical classifications of aphasia and AOS correlated with pathological diagnoses and specific biochemical and anatomical structural abnormalities. Seventeen cases with initial diagnoses of a degenerative aphasia or AOS were re-classified independently by two speech-language pathologists—blinded to pathological and biochemical findings—into one of five operationally defined categories of aphasia and AOS. Pathological diagnoses in the 17 cases were progressive supranuclear palsy in 6, corticobasal degeneration in 5, frontotemporal lobar degeneration with ubiquitin-only-immunoreactive changes in 5 and Pick's disease in 1. Magnetic resonance imaging analysis using voxel-based morphometry (VBM), and single photon emission tomography were completed, blinded to the clinical diagnoses, and clinicoimaging and clinicopathological associations were then sought. Interjudge clinical classification reliability was 87% (κ = 0.8) for all evaluations. Eleven cases had evidence of AOS, of which all (100%) had a pathological diagnosis characterized by underlying tau biochemistry, while five of the other six cases without AOS did not have tau biochemistry (P = 0.001). A majority of the 17 cases had more than one yearly evaluation, demonstrating the evolution of the speech and language syndromes, as well as motor signs. VBM revealed the premotor and supplemental motor cortices to be the main cortical regions associated with AOS, while the anterior peri-sylvian region was associated with non-fluent aphasia. Refining the classification of the degenerative aphasias and AOS may be necessary to improve our understanding of the relationships among behavioural, pathological and imaging correlations.

© The Author (2006). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Topic:

• magnetic resonance imaging
• nervous system disorders
• aphasia
• biochemistry
• languages
• dementia due to pick's disease
• sound
• speech
• progressive supranuclear palsy
• ubiquitin
• behavior
• diagnosis
• diagnostic imaging
• pathology
• prosody
• apraxia of speech
• frontotemporal lobar degeneration
• aphasia, progressive
• speech-language pathologists
• mapt gene
• speech rate
• clinical diagnosis

You do not currently have access to this article.

Personal account

• Sign in with email/username & password
• Get email alerts
• Save searches
• Purchase content
• Activate your purchase/trial code
• Add your ORCID iD

Get help with access

Institutional access

Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:

IP based access

Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.

Sign in through your institution

Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.

1. Click Sign in through your institution.
2. Select your institution from the list provided, which will take you to your institution's website to sign in.
3. When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
4. Following successful sign in, you will be returned to Oxford Academic.

If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.

Sign in with a library card

Enter your library card number to sign in. If you cannot sign in, please contact your librarian.

Society Members

Society member access to a journal is achieved in one of the following ways:

Sign in through society site

Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:

1. Click Sign in through society site.
2. When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
3. Following successful sign in, you will be returned to Oxford Academic.

If you do not have a society account or have forgotten your username or password, please contact your society.

Sign in using a personal account

Some societies use Oxford Academic personal accounts to provide access to their members. See below.

Personal account

A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.

Some societies use Oxford Academic personal accounts to provide access to their members.

Viewing your signed in accounts

Click the account icon in the top right to:

• View your signed in personal account and access account management features.
• View the institutional accounts that are providing access.

Signed in but can't access content

Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.

Institutional account management

For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.

Purchase

Short-term Access

To purchase short-term access, please sign in to your personal account above.

Don't already have a personal account? Register

Clinicopathological and imaging correlates of progressive aphasia and apraxia of speech - 24 Hours access

EUR €51.00

GBP £44.00

USD $55.00

Rental

This article is also available for rental through DeepDyve.

Citations

Views

Altmetric

Metrics

Total Views 7,726

5,886 Pageviews

1,840 PDF Downloads

Since 12/1/2016

Citations

510 Web of Science

×

Email alerts

Citing articles via

• Latest

• Most Read

• Most Cited

More from Oxford Academic