Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology (original) (raw)

Journal Article

,

1Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Rome, Italy and 2Department of Cellular and Molecular Neuroscience, Imperial College Faculty of Medicine, London, UK

Search for other works by this author on:

,

1Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Rome, Italy and 2Department of Cellular and Molecular Neuroscience, Imperial College Faculty of Medicine, London, UK

Search for other works by this author on:

,

1Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Rome, Italy and 2Department of Cellular and Molecular Neuroscience, Imperial College Faculty of Medicine, London, UK

Search for other works by this author on:

,

1Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Rome, Italy and 2Department of Cellular and Molecular Neuroscience, Imperial College Faculty of Medicine, London, UK

Search for other works by this author on:

,

1Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Rome, Italy and 2Department of Cellular and Molecular Neuroscience, Imperial College Faculty of Medicine, London, UK

Search for other works by this author on:

,

1Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Rome, Italy and 2Department of Cellular and Molecular Neuroscience, Imperial College Faculty of Medicine, London, UK

Search for other works by this author on:

,

1Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Rome, Italy and 2Department of Cellular and Molecular Neuroscience, Imperial College Faculty of Medicine, London, UK

Search for other works by this author on:

1Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Rome, Italy and 2Department of Cellular and Molecular Neuroscience, Imperial College Faculty of Medicine, London, UK

Search for other works by this author on:

Received:

04 December 2006

Revision received:

23 January 2007

Accepted:

12 February 2007

• • Article contents
  • Figures & tables
  • Video
  • Audio
  • Supplementary Data
• Cite

Cite

Roberta Magliozzi, Owain Howell, Abhilash Vora, Barbara Serafini, Richard Nicholas, Maria Puopolo, Richard Reynolds, Francesca Aloisi, Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology, Brain, Volume 130, Issue 4, April 2007, Pages 1089–1104, https://doi.org/10.1093/brain/awm038
Close

Navbar Search Filter Mobile Enter search term Search

Abstract

Intrathecal antibody production is a hallmark of multiple sclerosis and humoral immunity is thought to play an important role in the inflammatory response and development of demyelinated lesions. The presence of lymphoid follicle-like structures in the cerebral meninges of some multiple sclerosis patients indicates that B-cell maturation can be sustained locally within the CNS and contribute to the establishment of a compartmentalized humoral immune response. In this study we examined the distribution of ectopic B-cell follicles in multiple sclerosis cases with primary and secondary progressive clinical courses to determine their association with clinical and neuropathological features. A detailed immunohistochemical and morphometric analysis was performed on post-mortem brain tissue samples from 29 secondary progressive (SP) and 7 primary progressive (PP) multiple sclerosis cases. B-cell follicles were detected in the meninges entering the cerebral sulci of 41.4% of the SPMS cases, but not in PPMS cases. The SPMS cases with follicles significantly differed from those without with respect to a younger age at multiple sclerosis onset, irreversible disability and death and more pronounced demyelination, microglia activation and loss of neurites in the cerebral cortex. Cortical demyelination in these SPMS cases was also more severe than in PPMS cases. Notably, all meningeal B-cell follicles were found adjacent to large subpial cortical lesions, suggesting that soluble factors diffusing from these structures have a pathogenic role. These data support an immunopathogenetic mechanism whereby B-cell follicles developing in the multiple sclerosis meninges exacerbate the detrimental effects of humoral immunity with a subsequent major impact on the integrity of the cortical structures.

© The Author (2007). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Topic:

• b-lymphocytes
• hair follicle
• multiple sclerosis
• neurites
• ovarian follicle
• brain
• meninges
• pathology
• demyelination
• symptom onset

You do not currently have access to this article.

Personal account

• Sign in with email/username & password
• Get email alerts
• Save searches
• Purchase content
• Activate your purchase/trial code
• Add your ORCID iD

Get help with access

Institutional access

Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:

IP based access

Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.

Sign in through your institution

Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.

1. Click Sign in through your institution.
2. Select your institution from the list provided, which will take you to your institution's website to sign in.
3. When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
4. Following successful sign in, you will be returned to Oxford Academic.

If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.

Sign in with a library card

Enter your library card number to sign in. If you cannot sign in, please contact your librarian.

Society Members

Society member access to a journal is achieved in one of the following ways:

Sign in through society site

Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:

1. Click Sign in through society site.
2. When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
3. Following successful sign in, you will be returned to Oxford Academic.

If you do not have a society account or have forgotten your username or password, please contact your society.

Sign in using a personal account

Some societies use Oxford Academic personal accounts to provide access to their members. See below.

Personal account

A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.

Some societies use Oxford Academic personal accounts to provide access to their members.

Viewing your signed in accounts

Click the account icon in the top right to:

• View your signed in personal account and access account management features.
• View the institutional accounts that are providing access.

Signed in but can't access content

Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.

Institutional account management

For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.

Purchase

Short-term Access

To purchase short-term access, please sign in to your personal account above.

Don't already have a personal account? Register

Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology - 24 Hours access

EUR €51.00

GBP £44.00

USD $55.00

Rental

This article is also available for rental through DeepDyve.

Citations

Views

Altmetric

Metrics

Total Views 14,955

10,599 Pageviews

4,356 PDF Downloads

Since 12/1/2016

×

Email alerts

Citing articles via

• Latest

• Most Read

• Most Cited

More from Oxford Academic