Survival of midbrain dopaminergic cells after lesion or deep brain stimulation of the subthalamic nucleus in MPTP-treated monkeys (original) (raw)

Journal Article

,

1Department of Clinical and INSERM U318 Preclinical Neurosciences, University Joseph Fourier, Grenoble, France, 2Department of Neurosurgery, University of Florida, Gainesville, USA, 3Unit of Functional Neurosurgery, Institute of Neurology, London, England, 4Department of Anatomy & Histology, University of Sydney, Sydney and 5Medical School, Australian National University, Canberra, Australia

Search for other works by this author on:

,

1Department of Clinical and INSERM U318 Preclinical Neurosciences, University Joseph Fourier, Grenoble, France, 2Department of Neurosurgery, University of Florida, Gainesville, USA, 3Unit of Functional Neurosurgery, Institute of Neurology, London, England, 4Department of Anatomy & Histology, University of Sydney, Sydney and 5Medical School, Australian National University, Canberra, Australia

Search for other works by this author on:

,

1Department of Clinical and INSERM U318 Preclinical Neurosciences, University Joseph Fourier, Grenoble, France, 2Department of Neurosurgery, University of Florida, Gainesville, USA, 3Unit of Functional Neurosurgery, Institute of Neurology, London, England, 4Department of Anatomy & Histology, University of Sydney, Sydney and 5Medical School, Australian National University, Canberra, Australia

Search for other works by this author on:

,

1Department of Clinical and INSERM U318 Preclinical Neurosciences, University Joseph Fourier, Grenoble, France, 2Department of Neurosurgery, University of Florida, Gainesville, USA, 3Unit of Functional Neurosurgery, Institute of Neurology, London, England, 4Department of Anatomy & Histology, University of Sydney, Sydney and 5Medical School, Australian National University, Canberra, Australia

Search for other works by this author on:

,

1Department of Clinical and INSERM U318 Preclinical Neurosciences, University Joseph Fourier, Grenoble, France, 2Department of Neurosurgery, University of Florida, Gainesville, USA, 3Unit of Functional Neurosurgery, Institute of Neurology, London, England, 4Department of Anatomy & Histology, University of Sydney, Sydney and 5Medical School, Australian National University, Canberra, Australia

Search for other works by this author on:

,

1Department of Clinical and INSERM U318 Preclinical Neurosciences, University Joseph Fourier, Grenoble, France, 2Department of Neurosurgery, University of Florida, Gainesville, USA, 3Unit of Functional Neurosurgery, Institute of Neurology, London, England, 4Department of Anatomy & Histology, University of Sydney, Sydney and 5Medical School, Australian National University, Canberra, Australia

Search for other works by this author on:

1Department of Clinical and INSERM U318 Preclinical Neurosciences, University Joseph Fourier, Grenoble, France, 2Department of Neurosurgery, University of Florida, Gainesville, USA, 3Unit of Functional Neurosurgery, Institute of Neurology, London, England, 4Department of Anatomy & Histology, University of Sydney, Sydney and 5Medical School, Australian National University, Canberra, Australia

Search for other works by this author on:

Received:

02 January 2007

Revision received:

09 May 2007

• • Article contents
  • Figures & tables
  • Video
  • Audio
  • Supplementary Data
• Cite

Cite

Bradley A. Wallace, Keyoumars Ashkan, Claire E Heise, Kelly D Foote, Napoleon Torres, John Mitrofanis, Alim-Louis Benabid, Survival of midbrain dopaminergic cells after lesion or deep brain stimulation of the subthalamic nucleus in MPTP-treated monkeys, Brain, Volume 130, Issue 8, August 2007, Pages 2129–2145, https://doi.org/10.1093/brain/awm137
Close

Navbar Search Filter Mobile Enter search term Search

Abstract

We have examined dopaminergic cell survival after alteration of the subthalamic nucleus (STN) in methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys. The STN was lesioned with kainic acid (B series) or underwent deep brain stimulation (DBS) at high frequency (C series). In another series, MPTP-treated and non-MPTP-treated monkeys had no STN alteration (intact animals; A series). Animals were treated with MPTP either after (B1, C1) or before (B2, C2) STN alteration. We also explored the long-term (∼7 months) effect of DBS in non-MPTP-treated monkeys (D series). Brains were aldehyde-fixed and processed for routine Nissl staining and tyrosine hydroxylase immunocytochemistry. Our results showed that there were significantly more (20–24%) dopaminergic cells in the substantia nigra pars compacta (SNc) of the MPTP-treated monkeys that had STN alteration, either with kainic acid lesion or DBS, compared to the non-MPTP-treated monkeys (intact animals). We suggest that this saving or neuroprotection was due to a reduction in glutamate excitotoxicity, as a result of the loss or reduction of the STN input to the SNc. Our results also showed that SNc cell number in the B1 and C1 series were very similar to those in the B2 and C2 series. In the cases that had long-term DBS of the STN (D series), there was no adverse impact on SNc cell number. In summary, these results indicated that STN alteration offered neuroprotection to dopaminergic cells that would normally die as part of the disease process.

© The Author (2007). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Topic:

• dopamine
• 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
• cell count
• cercopithecidae
• kainic acid
• subthalamic nucleus
• deep brain stimulation

You do not currently have access to this article.

Personal account

• Sign in with email/username & password
• Get email alerts
• Save searches
• Purchase content
• Activate your purchase/trial code
• Add your ORCID iD

Get help with access

Institutional access

Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:

IP based access

Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.

Sign in through your institution

Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.

1. Click Sign in through your institution.
2. Select your institution from the list provided, which will take you to your institution's website to sign in.
3. When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
4. Following successful sign in, you will be returned to Oxford Academic.

If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.

Sign in with a library card

Enter your library card number to sign in. If you cannot sign in, please contact your librarian.

Society Members

Society member access to a journal is achieved in one of the following ways:

Sign in through society site

Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:

1. Click Sign in through society site.
2. When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
3. Following successful sign in, you will be returned to Oxford Academic.

If you do not have a society account or have forgotten your username or password, please contact your society.

Sign in using a personal account

Some societies use Oxford Academic personal accounts to provide access to their members. See below.

Personal account

A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.

Some societies use Oxford Academic personal accounts to provide access to their members.

Viewing your signed in accounts

Click the account icon in the top right to:

• View your signed in personal account and access account management features.
• View the institutional accounts that are providing access.

Signed in but can't access content

Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.

Institutional account management

For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.

Purchase

Short-term Access

To purchase short-term access, please sign in to your personal account above.

Don't already have a personal account? Register

Survival of midbrain dopaminergic cells after lesion or deep brain stimulation of the subthalamic nucleus in MPTP-treated monkeys - 24 Hours access

EUR €51.00

GBP £44.00

USD $55.00

Rental

This article is also available for rental through DeepDyve.

Citations

Views

Altmetric

Metrics

Total Views 2,143

1,404 Pageviews

739 PDF Downloads

Since 12/1/2016

Citations

187 Web of Science

×

Email alerts

Citing articles via

• Latest

• Most Read

• Most Cited

More from Oxford Academic