Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability (original) (raw)

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1 Nerviano Medical Sciences, Nerviano, 20014 Nerviano, Milan, Italy

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2 Department of Immunology and Inflammation, Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, Italy

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2 Department of Immunology and Inflammation, Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, Italy

3 Institute of Pathology, University of Piemonte Orientale, 28100 Novara, Italy

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2 Department of Immunology and Inflammation, Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, Italy

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2 Department of Immunology and Inflammation, Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, Italy

4 Department of Translational Medicine, University of Milan, 20121 Milan, Italy

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Received:

20 February 2009

Revision received:

27 April 2009

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Francesco Colotta, Paola Allavena, Antonio Sica, Cecilia Garlanda, Alberto Mantovani, Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability, Carcinogenesis, Volume 30, Issue 7, July 2009, Pages 1073–1081, https://doi.org/10.1093/carcin/bgp127
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Abstract

Inflammatory conditions in selected organs increase the risk of cancer. An inflammatory component is present also in the microenvironment of tumors that are not epidemiologically related to inflammation. Recent studies have begun to unravel molecular pathways linking inflammation and cancer. In the tumor microenvironment, smoldering inflammation contributes to proliferation and survival of malignant cells, angiogenesis, metastasis, subversion of adaptive immunity, reduced response to hormones and chemotherapeutic agents. Recent data suggest that an additional mechanism involved in cancer-related inflammation (CRI) is induction of genetic instability by inflammatory mediators, leading to accumulation of random genetic alterations in cancer cells. In a seminal contribution, Hanahan and Weinberg [(2000) Cell, 100, 57–70] identified the six hallmarks of cancer. We surmise that CRI represents the seventh hallmark.

© The Author 2009. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Topic:

• cytokine
• inflammation
• cancer
• genetics
• neoplasms
• tumor cells, malignant
• tumor microenvironment

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