Fatal Disseminated Mycobacterium smegmatis Infection in a Child with Inherited Interferon γ Receptor Deficiency (original) (raw)

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Catherine Pierre-Audigier

INSERM U429 and Service de Microbiologie, d'Anatomie Pathologique, and d'Immunologic Pédiatrique, Hôpital Necker-Enfants Malades

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Paris, France

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Unité de Génétique Mycobactérienne, and Centre de Référence des Mycobactéries, Institut Pasteur

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Paris, France

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INSERM U429 and Service de Microbiologie, d'Anatomie Pathologique, and d'Immunologic Pédiatrique, Hôpital Necker-Enfants Malades

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Paris, France

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Unité de Génétique Mycobactérienne, and Centre de Référence des Mycobactéries, Institut Pasteur

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Unité de Génétique Mycobactérienne, and Centre de Référence des Mycobactéries, Institut Pasteur

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Paris, France

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Paris, France

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Unité de Génétique Mycobactérienne, and Centre de Référence des Mycobactéries, Institut Pasteur

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INSERM U429 and Service de Microbiologie, d'Anatomie Pathologique, and d'Immunologic Pédiatrique, Hôpital Necker-Enfants Malades

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Paris, France

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Unité de Génétique Mycobactérienne, and Centre de Référence des Mycobactéries, Institut Pasteur

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Paris, France

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INSERM U429 and Service de Microbiologie, d'Anatomie Pathologique, and d'Immunologic Pédiatrique, Hôpital Necker-Enfants Malades

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Paris, France

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Unité de Génétique Mycobactérienne, and Centre de Référence des Mycobactéries, Institut Pasteur

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Paris, France

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Paris, France

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Unité de Génétique Mycobactérienne, and Centre de Référence des Mycobactéries, Institut Pasteur

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Paris, France

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Revision received:

19 September 1996

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Catherine Pierre-Audigier, Emmanuelle Jouanguy, Salma Lamhamedi, Frédéric Altare, Jean Rauzier, Véronique Vincent, Danielle Canioni, Jean-François Emile, Alain Fischer, Stéphane Blanche, Jean-Louis Gaillard, Jean-Laurent Casanova, Fatal Disseminated Mycobacterium smegmatis Infection in a Child with Inherited Interferon γ Receptor Deficiency, Clinical Infectious Diseases, Volume 24, Issue 5, May 1997, Pages 982–984, https://doi.org/10.1093/clinids/24.5.982
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Abstract

Mycobacterium smegmatis is a common environmental mycobacterium that was first identified in 1884, yet is a rare pathogen in humans. The few M. smegmatis infections reported to date have been localized and have occurred in association with a primary lesion in otherwise immunocompetent individuals. To our knowledge, no case of disseminated M. smegmatis infection has ever been reported, even in patients with severe immune deficiencies. We report a case of disseminated mycobacterial infection that was diagnosed in a 3-year-old girl. The pathogen was not identified as M. smegmatis until the patient was 6 years old. Her condition gradually worsened, and she died when she was 8 years old despite appropriate antimycobacterial therapy. No other opportunistic infections were documented. Immunological investigations revealed an inherited interferon γ receptor 1 deficiency. This report identifies M. smegmatis as a new opportunistic agent that may be responsible for disseminated disease in immunocompromised individuals.

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© 1997 by The University of Chicago

Topic:

• child
• immunocompetence
• immunocompromised host
• interferons
• mycobacterium
• mycobacterium infections
• mycobacterium smegmatis
• opportunistic infections
• infections
• pathogenic organism
• antimycobacterial agents
• human leukocyte interferon
• deficiency, immune
• pathogenicity

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