Compilation of All Genes Encoding Two-component Phosphotransfer Signal Transducers in the Genome of Escherichia coli (original) (raw)

Journal Article

Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University

Chikusa-ku, Nagoya 464, Japan

* To whom correspondence should be addressed. Tel. +81-52-789-4089, Fax. +81-52-789-4091

Search for other works by this author on:

Received:

21 February 1997

• PDF
• Split View
• • Article contents
  • Figures & tables
  • Video
  • Audio
  • Supplementary Data
• Cite

Cite

Takeshi Mizuno, Compilation of All Genes Encoding Two-component Phosphotransfer Signal Transducers in the Genome of Escherichia coli, DNA Research, Volume 4, Issue 2, 1997, Pages 161–168, https://doi.org/10.1093/dnares/4.2.161
Close

Navbar Search Filter Mobile Enter search term Search

Abstract

Bacteria have devised sophisticated His-Asp phosphorelay signaling systems for eliciting a variety of adaptive responses to their environment, which are generally referred to as the “two-component regulatory system.” The widespread occurrence of the His-Asp phosphorelay signaling in both prokaryotes and eukaryotes implies that it is a powerful device for a wide variety of adaptive responses of cells to their environment. The two-component signal transducers contain one or more of three common and characteristic phosphotransfer signaling domains, named the “transmitter, receiver, and histidine-containing phosphotransfer (HPt) domains.” The recently determined entire genomic sequence of Escherichia coli allowed us to compile systematically a complete list of genes encoding such two-component signal transduction proteins. The results of such an effort, made in this study, revealed that at least 62 open reading frames(ORFs) were identified as putative members of the two-component signaltransducers in this single species. Among them, 32 were identified as response regulator and 23 were identified as orthodox sensory kinases. In addition, E. coli has five hybrid sensory kinases. The precise location of each ORF was mapped on a physical map of the entire E. coli genome. All of these ORFs were then compiled and annotated extensively.

This content is only available as a PDF.

Kazusa DNA Research Institute

Citations

Views

Altmetric

Metrics

Total Views 1,173

125 Pageviews

1,048 PDF Downloads

Since 1/1/2017

×

Email alerts

Citing articles via

• Latest

• Most Read

• Most Cited

More from Oxford Academic