Structure and expression of hybrid dysgenesis-induced alleles of the ovarian tumor (otu) gene in Drosophila melanogaster. (original) (raw)
Journal Article
,
Search for other works by this author on:
,
Search for other works by this author on:
,
Search for other works by this author on:
,
Search for other works by this author on:
Search for other works by this author on:
Published:
01 February 1993
PDF Cite
G L Sass, J D Mohler, R C Walsh, L J Kalfayan, L L Searles, Structure and expression of hybrid dysgenesis-induced alleles of the ovarian tumor (otu) gene in Drosophila melanogaster., Genetics, Volume 133, Issue 2, 1 February 1993, Pages 253–263, https://doi.org/10.1093/genetics/133.2.253
Close
Navbar Search Filter Mobile Enter search term Search
Abstract
Mutations at the ovarian tumor (otu) gene of Drosophila melanogaster cause female sterility and generate a range of ovarian phenotypes. Quiescent (QUI) mutants exhibit reduced germ cell proliferation; in oncogenic (ONC) mutants germ cells undergo uncontrolled proliferation generating excessive numbers of undifferentiated cells; the egg chambers of differentiated (DIF) mutants differentiate to variable degrees but fail to complete oogenesis. We have examined mutations caused by insertion and deletion of P elements at the otu gene. The P element insertion sites are upstream of the major otu transcription start sites. In deletion derivatives, the P element, regulatory regions and/or protein coding sequences have been removed. In both insertion and deletion mutants, the level of otu expression correlates directly with the severity of the phenotype: the absence of otu function produces the most severe QUI phenotype while the ONC mutants express lower levels of otu than those which are DIF. The results of this study demonstrate that the diverse mutant phenotypes of otu are the consequence of different levels of otu function.
This content is only available as a PDF.
© Genetics 1993
Citations
Views
Altmetric
Metrics
Total Views 68
0 Pageviews
68 PDF Downloads
Since 1/1/2021
| Month: | Total Views: |
|---|---|
| January 2021 | 3 |
| March 2021 | 1 |
| July 2021 | 1 |
| October 2021 | 2 |
| November 2021 | 1 |
| January 2022 | 2 |
| March 2022 | 1 |
| April 2022 | 1 |
| July 2022 | 2 |
| August 2022 | 1 |
| November 2022 | 2 |
| December 2022 | 1 |
| February 2023 | 1 |
| March 2023 | 2 |
| June 2023 | 1 |
| July 2023 | 2 |
| September 2023 | 1 |
| December 2023 | 4 |
| January 2024 | 4 |
| March 2024 | 2 |
| April 2024 | 10 |
| May 2024 | 1 |
| June 2024 | 2 |
| July 2024 | 13 |
| August 2024 | 3 |
| September 2024 | 1 |
| October 2024 | 3 |
×
Email alerts
Citing articles via
More from Oxford Academic